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Metabolite damage and its repair or pre-emption.

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Linster, Carole L [UCL] Van Schaftingen, Emile [UCL] Hanson, Andrew D [-]

It is increasingly evident that metabolites suffer various kinds of damage, that such damage happens in all organisms and that cells have dedicated systems for damage repair and containment. First, chemical biology is demonstrating that diverse metabolites are damaged by side reactions of 'promiscuous' enzymes or by spontaneous chemical reactions, that the products are useless or toxic and that the unchecked buildup of these products can be devastating. Second, genetic and genomic evidence from prokaryotes and eukaryotes is implicating a network of new, conserved enzymes that repair damaged metabolites or somehow pre-empt damage. Metabolite (that is, small-molecule) repair is analogous to macromolecule (DNA and protein) repair and seems from comparative genomic evidence to be equally widespread. Comparative genomics also implies that metabolite repair could be the function of many conserved protein families lacking known activities. How-and how well-cells deal with metabolite damage affects fields ranging from medical genetics to metabolic engineering.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2013
Language Anglais
Journal information "Nature Chemical Biology" - Vol. 9, no.2, p. 72-80 (2013)
Peer reviewed yes
Publisher Nature Publishing Group ((United Kingdom) London)
issn 1552-4450
e-issn 1552-4469
Publication status Publié
Affiliation UCL - SSS/DDUV - Institut de Duve
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Bibliographic reference Linster, Carole L ; Van Schaftingen, Emile ; Hanson, Andrew D. Metabolite damage and its repair or pre-emption.. In: Nature Chemical Biology, Vol. 9, no.2, p. 72-80 (2013)
Permanent URL http://hdl.handle.net/2078.1/123557