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Genetic loci influencing kidney function and chronic kidney disease.

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Chambers, John C Zhang, Weihua Lord, Graham M van der Harst, Pim Lawlor, Debbie A Devuyst, Olivier [UCL] Maréchal, Céline [UCL]

Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.

Document type Article de périodique (Journal article)
Access type Accès restreint
Publication date 2010
Language Anglais
Journal information "Nature Genetics" - Vol. 42, no.5, p. 373-375 (2010)
Peer reviewed yes
Publisher Nature Publishing Group ((United States) New York)
issn 1061-4036
e-issn 1546-1718
Publication status Publié
Affiliations UCL - SSS/IREC/NEFR - Pôle de Néphrologie
UCL - (SLuc) Service de néphrologie
MESH Subject Biological Transport ; Genotype ; Glomerular Filtration Rate ; Humans ; Kidney ; Kidney Failure, Chronic ; Models, Genetic ; Creatinine ; Cystatin C ; Europe ; Gene Expression Regulation ; Genetic Markers ; Genetic Predisposition to Disease ; Genetic Variation ; Genome-Wide Association Study
Links
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Bibliographic reference Chambers, John C ; Zhang, Weihua ; Lord, Graham M ; van der Harst, Pim ; Lawlor, Debbie A ; et. al. Genetic loci influencing kidney function and chronic kidney disease.. In: Nature Genetics, Vol. 42, no.5, p. 373-375 (2010)
Permanent URL http://hdl.handle.net/2078.1/123141