User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Nucleotide sequence analysis of a 40 kb segment on the right arm of yeast chromosome XV reveals 18 open reading frames including a new pyruvate kinase and three homologues to chromosome I genes.

Primary tabs

Purnelle, Bénédicte [UCL] Goffeau, André [UCL]

We have determined the nucleotide sequence of a 40 kb fragment from the right arm of chromosome XV of Saccharomyces cerevisiae. Subsequent analysis revealed 18 non-overlapping open reading frames (ORFs) numbered from 06257 to 06357, an ARS, two tRNA genes and a Ty2 with its flanking elements. Ten ORFs have been sequenced previously: TEA1, RPA43, RPA190, SGC1 (also called TYE7) REV1, PUT4, CIN1, MNE and MRE4 (also called MEK1). Among the others, two seem to code for a new pyruvate kinase and for a new ubiquitin-conjugating enzyme; three have interesting homology with genes located on the left arm of chromosome I. This similarity with chromosome I extends to the left of the sequence presented here (Parle et al., submitted to Yeast). The homologous genes on the two chromosomes are placed in the same relative order.

Document type Article de périodique (Journal article) – Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
Publication date 1996
Journal information "Yeast (Chichester, England)" - Vol. 12, no. 14, p. 1475-81 (1996)
Peer reviewed yes
issn 0749-503X
Publication status Publié
Affiliation UCL - AGRO/CABI - Département de chimie appliquée et des bio-industries
MESH Subject Amino Acid Sequence ; Chromosomes, Fungal - genetics ; DNA, Fungal - genetics ; Genes, Fungal ; Molecular Sequence Data ; Open Reading Frames ; Pyruvate Kinase - genetics ; RNA, Transfer - genetics ; Saccharomyces cerevisiae - genetics ; Sequence Analysis, DNA ; Sequence Homology, Amino Acid
Links
  1. Åström Stefan U., von Pawel-Rammingen Ulrich, Byström Anders S., The Yeast Initiator tRNAMet can Act as an Elongator tRNAMetIn Vivo, 10.1006/jmbi.1993.1483
  2. Bairoch A., Prosite: a dictionary of sites and patterns in proteins, 10.1093/nar/19.suppl.2241
  3. Berben Gilbert, Legrain Michèle, Gilliquet Véronique, Hilger François, The yeast regulatory genePHO4 encodes a helix-loop-helix motif, 10.1002/yea.320060510
  4. Boeke, Molecular and Cellular Biology of the Yeast Saccharomyces, 1, 193 (1991)
  5. Burke, J. Biol. Chem., 258, 2193 (1983)
  6. Bussey H., Kaback D. B., Zhong W., Vo D. T., Clark M. W., Fortin N., Hall J., Ouellette B. F., Keng T., Barton A. B., The nucleotide sequence of chromosome I from Saccharomyces cerevisiae., 10.1073/pnas.92.9.3809
  7. Clare J., Farabaugh P., Nucleotide sequence of a yeast Ty element: evidence for an unusual mechanism of gene expression., 10.1073/pnas.82.9.2829
  8. Devereux John, Haeberli Paul, Smithies Oliver, A comprehensive set of sequence analysis programs for the VAX, 10.1093/nar/12.1part1.387
  9. Fickett James W., Recognition of protein coding regions in DNA sequences, 10.1093/nar/10.17.5303
  10. Goffeau A., Slonimski P., Risler J. L., Nakai K., How many yeast genes code for membrane-spanning proteins?, 10.1002/yea.320090703
  11. Gray W M, Fassler J S, Isolation and analysis of the yeast TEA1 gene, which encodes a zinc cluster Ty enhancer-binding protein., 10.1128/mcb.16.1.347
  12. Harris Steven D., Cheng Judy, Pugh Tom A., Pringle John R., Molecular analysis of Saccharomyces cerevisiae chromosome I, 10.1016/0022-2836(92)91025-k
  13. Hinnebusch A. G., Fink G. R., Positive regulation in the general amino acid control of Saccharomyces cerevisiae., 10.1073/pnas.80.17.5374
  14. Hoyt M A, Stearns T, Botstein D, Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes., 10.1128/mcb.10.1.223
  15. Jentsch Stefan, Seufert Wolfgang, Sommer Thomas, Reins Hans-Albert, Ubiquitin-conjugating enzymes: novel regulators of eukaryotic cells, 10.1016/0968-0004(90)90161-4
  16. Ji H., Moore D.P., Blomberg M.A., Braiterman L.T., Voytas D.F., Natsoulis G., Boeke J.D., Hotspots for unselected Ty1 transposition events on yeast chromosome III are near tRNA genes and LTR sequences, 10.1016/0092-8674(93)90278-x
  17. Kalinowski Douglas P., Larimer Frank W., Plewa Michael J., Analysis of spontaneous frameshift mutations in REV1 and rev1-1 strains of Saccharomyces cerevisiae, 10.1016/0027-5107(95)00064-p
  18. Klein Petr, Kanehisa Minoru, DeLisi Charles, The detection and classification of membrane-spanning proteins, 10.1016/0005-2736(85)90375-x
  19. Larimer F W, Perry J R, Hardigree A A, The REV1 gene of Saccharomyces cerevisiae: isolation, sequence, and functional analysis., 10.1128/jb.171.1.230-237.1989
  20. Leem Sun-Hee, Ogawa Hideyuki, TheMRE4gene encodes a rovel protein kinase homologue recuired for meiotic recombination inSaccharomyces cerevisiae, 10.1093/nar/20.3.449
  21. Löhning Corinna, Ciriacy Michael, TheTYE7 gene ofSaccharomyces cerevisiae encodes a putative bHLH-LZ transcription factor required for Tyl-mediated gene expression, 10.1002/yea.320101010
  22. McNally Teresa, Purvis Ian J., Fothergill-Gilmore Linda A., Brown Alistair J.P., The yeast pyruvate kinase gene does not contain a string of non- preferred codons: Revised nucleotide sequence, 10.1016/0014-5793(89)81359-6
  23. Mémet, J. Biol. Chem., 263, 2830 (1988)
  24. MUIRHEAD HILARY, Isoenzymes of pyruvate kinase, 10.1042/bst0180193
  25. Nakai Kenta, Kanehisa Minoru, A knowledge base for predicting protein localization sites in eukaryotic cells, 10.1016/s0888-7543(05)80111-9
  26. Nishi K, Park C S, Pepper A E, Eichinger G, Innis M A, Holland M J, The GCR1 requirement for yeast glycolytic gene expression is suppressed by dominant mutations in the SGC1 gene, which encodes a novel basic-helix-loop-helix protein., 10.1128/mcb.15.5.2646
  27. Ogden Richard C., Lee Ming-Chou, Knapp Gayle, Transfer RNA splicing inSaccharomyces cerevisiae: defining the substrates, 10.1093/nar/12.24.9367
  28. Palzkill Timothy G., Oliver Stephen G., Newlon Carol S., DNA sequence analysis ofARSelements from chromosome III ofSaccharomyces cerevisiae: identification of a new conserved sequence, 10.1093/nar/14.15.6247
  29. Pearson W. R., Lipman D. J., Improved tools for biological sequence comparison., 10.1073/pnas.85.8.2444
  30. Penn M. D., Galgoci B., Greer H., Identification of AAS genes and their regulatory role in general control of amino acid biosynthesis in yeast., 10.1073/pnas.80.9.2704
  31. Purnelle Bénédicte, Skala Jacek, Van Dyack Luc, Goffeau André, XI. Yeast sequencing reports. The sequence of a 12kb fragment on the left arm of yeast chromosome XI reveals five new open reading frames, including a zinc finger protein and a homolog of the UDP-glucose pyrophosphorylase from potato, 10.1002/yea.320081108
  32. Purnelle Bénédicte, Coster Françoise, Goffeau André, X. Yeast sequencing reports. The sequence of a 36 kb segment on the left arm of yeast chromosome X identifies 24 open reading frames includingNUC1, PRP21 (SPP91), CDC6, CRY2, the gene for S24, a homologue to the aconitase geneACO1 and two homologues to chromosome III genes, 10.1002/yea.320100912
  33. Reynolds P., Weber S., Prakash L., RAD6 gene of Saccharomyces cerevisiae encodes a protein containing a tract of 13 consecutive aspartates., 10.1073/pnas.82.1.168
  34. Rockmill B, Roeder G S, A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination., 10.1101/gad.5.12b.2392
  35. Sharp Paul M., Li Wen-Hsiung, The codon adaptation index-a measure of directional synonymous codon usage bias, and its potential applications, 10.1093/nar/15.3.1281
  36. Slater Michael R., Craig Elizabeth A., TheSSAIandSSA2genes of the yeastSaccharomyces cerevisiae, 10.1093/nar/17.2.805
  37. Stearns, Genetics, 124, 251 (1990)
  38. Thuriaux Pierre, Mariotte Sylvie, Buhler Jean-Marie, Sentenac André, Vu Loan, Lee Bum-Soo, Nomura Masayasu, GeneRPA43inSaccharomyces cerevisiaeEncodes an Essential Subunit of RNA Polymerase I, 10.1074/jbc.270.41.24252
  39. Vandenbol Micheline, Jauniaux Jean-Claude, Grenson Marcelle, Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases, 10.1016/0378-1119(89)90413-7
  40. Warmington John R., Waring Richard B., Newlon Carol S., Indge Keith J., Oliver Stephen G., Nucleotlde sequence characterization of Ty 1–17 , a class II transposon from yeast, 10.1093/nar/13.18.6679
Bibliographic reference Purnelle, Bénédicte ; Goffeau, André. Nucleotide sequence analysis of a 40 kb segment on the right arm of yeast chromosome XV reveals 18 open reading frames including a new pyruvate kinase and three homologues to chromosome I genes.. In: Yeast (Chichester, England), Vol. 12, no. 14, p. 1475-81 (1996)
Permanent URL http://hdl.handle.net/2078.1/12259