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Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injury.

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Leclercq, Isabelle [UCL] Field, Jacqueline Farrell, Geoffrey C

Impaired liver regeneration in ob/ob mice is caused by leptin deficiency. We propose that altered cytokine production in ob/ob mice is part of the mechanisms responsible for impaired proliferation in response to hepatic injury.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2003
Language Anglais
Journal information "Gastroenterology" - Vol. 124, no. 5, p. 1451-1464 (2003)
Peer reviewed yes
Publisher W.B.Saunders Co. ((United States) Philadelphia)
issn 0016-5085
e-issn 1528-0012
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service d'hépato-gastro-entérologie
MESH Subject Animals ; Liver Regeneration ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Necrosis ; Proliferating Cell Nuclear Antigen ; Recombinant Proteins ; Signal Transduction ; Tumor Necrosis Factor-alpha ; Carbon Tetrachloride ; Cell Division ; Cyclin D1 ; Drug-Induced Liver Injury ; Fatty Liver ; Interleukin-6 ; Leptin ; Liver
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Bibliographic reference Leclercq, Isabelle ; Field, Jacqueline ; Farrell, Geoffrey C. Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injury.. In: Gastroenterology, Vol. 124, no. 5, p. 1451-1464 (2003)
Permanent URL http://hdl.handle.net/2078.1/121996