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Demethylation of the FOXP3 gene in human melanoma cells precludes the use of this epigenetic mark for quantification of Tregs in unseparated melanoma samples.

Bibliographic reference Lucas, Sophie ; van Baren, Nicolas ; De Smet, Charles ; Coulie, Pierre. Demethylation of the FOXP3 gene in human melanoma cells precludes the use of this epigenetic mark for quantification of Tregs in unseparated melanoma samples.. In: International Journal of Cancer, Vol. 130, no. 8, p. 1960-1966 (2012)
Permanent URL http://hdl.handle.net/2078/121109
  1. Zheng Ye, Rudensky Alexander Y, Foxp3 in control of the regulatory T cell lineage, 10.1038/ni1455
  2. Sakaguchi Shimon, Miyara Makoto, Costantino Cristina M., Hafler David A., FOXP3+ regulatory T cells in the human immune system, 10.1038/nri2785
  3. Colombo Mario P., Piconese Silvia, Regulatory T-cell inhibition versus depletion: the right choice in cancer immunotherapy, 10.1038/nrc2250
  4. Wang Helen Y, Wang Rong-Fu, Regulatory T cells and cancer, 10.1016/j.coi.2007.02.004
  5. Gavin M. A., Torgerson T. R., Houston E., deRoos P., Ho W. Y., Stray-Pedersen A., Ocheltree E. L., Greenberg P. D., Ochs H. D., Rudensky A. Y., Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development, 10.1073/pnas.0509484103
  6. Stockis Julie, Fink Wolfram, François Violaine, Connerotte Thierry, de Smet Charles, Knoops Laurent, van der Bruggen Pierre, Boon Thierry, Coulie Pierre G., Lucas Sophie, Comparison of stable human Treg and Th clones by transcriptional profiling : Molecular immunology, 10.1002/eji.200838807
  7. Francois V., Ottaviani S., Renkvist N., Stockis J., Schuler G., Thielemans K., Colau D., Marchand M., Boon T., Lucas S., van der Bruggen P., The CD4+ T-Cell Response of Melanoma Patients to a MAGE-A3 Peptide Vaccine Involves Potential Regulatory T Cells, 10.1158/0008-5472.can-08-3726
  8. Tran D. Q., Ramsey H., Shevach E. M., Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-  dependent but does not confer a regulatory phenotype, 10.1182/blood-2007-06-094656
  9. de Vries I. J. M., Castelli C., Huygens C., Jacobs J. F. M., Stockis J., Schuler-Thurner B., Adema G. J., Punt C. J. A., Rivoltini L., Schuler G., Coulie P. G., Lucas S., Frequency of Circulating Tregs with Demethylated FOXP3 Intron 1 in Melanoma Patients Receiving Tumor Vaccines and Potentially Treg-Depleting Agents, 10.1158/1078-0432.ccr-10-2227
  10. Lurquin Christophe, Lethé Bernard, De Plaen Etienne, Corbière Véronique, Théate Ivan, van Baren Nicolas, Coulie Pierre G., Boon Thierry, Contrasting frequencies of antitumor and anti-vaccine T cells in metastases of a melanoma patient vaccinated with a MAGE tumor antigen, 10.1084/jem.20041378
  11. LEVY L, HILL C, Alterations in components of the TGF-β superfamily signaling pathways in human cancer, 10.1016/j.cytogfr.2005.09.009
  12. Baron Udo, Floess Stefan, Wieczorek Georg, Baumann Katrin, Grützkau Andreas, Dong Jun, Thiel Andreas, Boeld Tina J., Hoffmann Petra, Edinger Matthias, Türbachova Ivana, Hamann Alf, Olek Sven, Huehn Jochen, DNA demethylation in the humanFOXP3 locus discriminates regulatory T cells from activated FOXP3+ conventional T cells, 10.1002/eji.200737594
  13. Floess Stefan, Freyer Jennifer, Siewert Christiane, Baron Udo, Olek Sven, Polansky Julia, Schlawe Kerstin, Chang Hyun-Dong, Bopp Tobias, Schmitt Edgar, Klein-Hessling Stefan, Serfling Edgar, Hamann Alf, Huehn Jochen, Epigenetic Control of the foxp3 Locus in Regulatory T Cells, 10.1371/journal.pbio.0050038
  14. Zheng Ye, Josefowicz Steven, Chaudhry Ashutosh, Peng Xiao P., Forbush Katherine, Rudensky Alexander Y., Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate, 10.1038/nature08750
  15. Wieczorek G., Asemissen A., Model F., Turbachova I., Floess S., Liebenberg V., Baron U., Stauch D., Kotsch K., Pratschke J., Hamann A., Loddenkemper C., Stein H., Volk H. D., Hoffmuller U., Grutzkau A., Mustea A., Huehn J., Scheibenbogen C., Olek S., Quantitative DNA Methylation Analysis of FOXP3 as a New Method for Counting Regulatory T Cells in Peripheral Blood and Solid Tissue, 10.1158/0008-5472.can-08-2361
  16. Fantini M. C., Becker C., Monteleone G., Pallone F., Galle P. R., Neurath M. F., Cutting Edge: TGF-  Induces a Regulatory Phenotype in CD4+CD25- T Cells through Foxp3 Induction and Down-Regulation of Smad7, 10.4049/jimmunol.172.9.5149
  17. Hinz S., Pagerols-Raluy L., Oberg H.-H., Ammerpohl O., Grussel S., Sipos B., Grutzmann R., Pilarsky C., Ungefroren H., Saeger H.-D., Kloppel G., Kabelitz D., Kalthoff H., Foxp3 Expression in Pancreatic Carcinoma Cells as a Novel Mechanism of Immune Evasion in Cancer, 10.1158/0008-5472.can-06-3304
  18. Loddenkemper Christoph, Hoffmann Corinna, Stanke Jonas, Nagorsen Dirk, Baron Udo, Olek Sven, Huehn Jochen, Ritz Joerg-Peter, Stein Harald, Kaufmann Andreas M., Schneider Achim, Cichon Günter, Regulatory (FOXP3+) T cells as target for immune therapy of cervical intraepithelial neoplasia and cervical cancer, 10.1111/j.1349-7006.2009.01153.x
  19. Sehouli Jalid, Loddenkemper Christoph, Cornu Tatjana, Schwachula Tim, Hoffmüller Ulrich, Grützkau Andreas, Lohneis Philipp, Dickhaus Thorsten, Gröne Jörn, Kruschewski Martin, Mustea Alexander, Turbachova Ivana, Baron Udo, Olek Sven, Epigenetic quantification of tumor-infiltrating T-lymphocytes, 10.4161/epi.6.2.13755
  20. De Smet Charles, Loriot Axelle, DNA hypomethylation in cancer: Epigenetic scars of a neoplastic journey, 10.4161/epi.5.3.11447
  21. De Smet Charles, Lurquin Christophe, Lethé Bernard, Martelange Valérie, Boon Thierry, DNA Methylation Is the Primary Silencing Mechanism for a Set of Germ Line- and Tumor-Specific Genes with a CpG-Rich Promoter, 10.1128/mcb.19.11.7327