Authors 
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Document type 
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Article de périodique (Journal article) – Comparative Study, Journal Article, Research Support, NonU.S. Gov't

Abstract 
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The lung tolerance in mice after single and fractionated irradiations with p(45)+Be and p(65)+Be neutrons produced at the isochronous cyclotron "CYCLONE" of LouvainlaNeuve (Belgium) was studied. Cobalt60 gamma rays were used for control irradiations. The end point was the dose which was lethal to 50% of the mice by 180 days (LD50/180). On a loglog plot, the slope (+/ SE) of the relationship between total isoeffect dose and fraction number decreases from 0.34 +/ 0.01 for gamma rays to 0.19 +/ 0.01 for p(65)+Be and 0.12 +/ 0.01 for p(45)+Be neutrons. The data have been analyzed using the linearquadratic (LQ) model. The alpha/beta ratio (+95% confidence interval) increases from 5.3 (4.36.4) for gamma rays to 20.7 (16.724.9) for p(65)+Be and 37.9 (25.865.8) for p(45)+Be. The RBEs of neutrons relative to gamma rays were estimated from the LQ parameters, to 1.15 and 1.19 for a dose of 14 Gy gamma rays and 2.02 and 2.47 for a dose of 2 Gy gamma rays for p(65)+Be and p(45)+Be neutrons, respectively. The neutron RBE of the p(45)+Be relative to the p(65)+Be calculated from the ratio of their respective RBEs relative to gamma rays reaches 1.03 and 1.23 for doses of 14 and 2 Gy gammaray equivalent, respectively. These data are compared with other published data on lung tolerance after irradiation with lowerenergy neutrons and with data obtained previously in our laboratory on mouse jejunum and Vicia faba. 
Access type 
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Accès restreint 
Publication date 
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1993 
Journal information 
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"Radiation research"  Vol. 133, no. 1, p. 2732 (1993) 
Peer reviewed 
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yes 
issn 
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00337587 
Publication status 
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Publié 
Affiliation 
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UCL
 MD/RAIM  Département de radiologie et d'imagerie médicale

MESH Subject 
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Animals ; Beryllium ; Cyclotrons ; Fast Neutrons ; Female ; Lung  radiation effects ; Mice ; Radiation Dosage ; Radiation Tolerance ; Relative Biological Effectiveness

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