User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder.

Primary tabs

Goossens, Dirk Villafuerte, Sandra Tissir, Fadel [UCL] Van Gestel, Sofie Claes, Stephan Del-Favero, Jurgen

We previously identified 18q21.33-q23 as a candidate region in one BP family and constructed a yeast artificial chromosome (YAC) contig map. Here, we mapped eight known CAG/CTG repeats relative to 18q21.33-q23. We also isolated four CAG/CTG repeats from within the region using CAG/CTG YAC fragmentation, one of which is located in the 5' untranslated region of the CAP2 gene coding for a brain-expressed serine proteinase inhibitor. The triplet repeats located in the 18q21.33-q23 BP candidate region showed no expanded alleles in the linked BP family nor in a BP case-control sample. Moreover, only the CAP2 triplet repeat was polymorphic but no genetic association with BP disorder was observed.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2000
Language Anglais
Journal information "European Journal of Human Genetics" - Vol. 8, no.5, p. 385-8 (2000)
Peer reviewed yes
Publisher Nature Publishing Group ((United Kingdom) London)
issn 1018-4813
e-issn 1476-5438
Publication status Publié
Affiliation UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
MESH Subject Bipolar Disorder ; Chromosome Mapping ; Chromosomes, Artificial, Yeast ; Chromosomes, Human, Pair 18 ; Female ; Humans ; Karyotyping ; Male ; Trinucleotide Repeats
Links
Bibliographic reference Goossens, Dirk ; Villafuerte, Sandra ; Tissir, Fadel ; Van Gestel, Sofie ; Claes, Stephan ; et. al. No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder.. In: European Journal of Human Genetics, Vol. 8, no.5, p. 385-8 (2000)
Permanent URL http://hdl.handle.net/2078.1/121061