User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Predisposition to familial osteoarthrosis linked to type II collagen gene.

Primary tabs

Palotie, A Väisänen, P Ott, J Ryhänen, L Elima, K Vikkula, Miikka [UCL] Peltonen, L

The genetic background of two families, in whom a predisposition to primary osteoarthrosis is inherited as a dominant trait, was investigated. Use of restriction fragment length polymorphisms within and around the type II collagen gene on chromosome 12 revealed a linkage between this cartilage-specific gene and primary osteoarthrosis.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1989
Language Anglais
Journal information "Lancet" - Vol. 1, no.8644, p. 924-7 (1989)
Peer reviewed yes
Publisher Elsevier
issn 0140-6736
Publication status Publié
Affiliation UCL - SSS/DDUV - Institut de Duve
MESH Subject Adult ; Humans ; Male ; Middle Aged ; Mutation ; Osteoarthritis ; Pedigree ; Polymorphism, Restriction Fragment Length ; Severity of Illness Index ; Age Factors ; Chromosomes, Human, Pair 12 ; Collagen ; DNA ; Disease Susceptibility ; Female ; Genes, Dominant ; Genetic Linkage
Links
Bibliographic reference Palotie, A ; Väisänen, P ; Ott, J ; Ryhänen, L ; Elima, K ; et. al. Predisposition to familial osteoarthrosis linked to type II collagen gene.. In: Lancet, Vol. 1, no.8644, p. 924-7 (1989)
Permanent URL http://hdl.handle.net/2078.1/120819