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Influence of viral infection on anti-erythrocyte autoantibody response after immunization of mice with rat red blood cells

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Verdonck, Elise Pfau, Charles J. Gonzalez, Maria-Dolores [UCL] Masson, Pierre [UCL] Coutelier, Jean-Paul [UCL]

Natural or deliberate activation of the immune system of pathogen-free mice markedly affected their response to an autoimmune-inducing stimulus. Specifically, mice immunized with rat red blood cells were found to make antibodies reactive with both rat and mouse erythrocytes. Animals housed for an extended period in a conventional environment developed an autoimmune response twice as fast as those kept in isolators. In an attempt to emulate this effect, mice kept in a sterile environment were infected with a potent polyclonal activator of B lymphocytes, lactate dehydrogenase-elevating virus, at the same time as they were inoculated with rat erythrocytes. Whereas uninfected animals developed a progressively increasing autoantibody titer, infected mice quickly attained high anti-erythrocyte autoantibody titers that remained rather constant. Contrary to circulating autoantibodies, bound anti-erythrocyte antibodies decreased with time. Virus infection enhanced all the IgG subclass responses, with the exception of IgG1, to both rat and mouse erythrocytes. None of the modifications of the autoimmune responses resulted in anemia.

  1. Cohen Irun R, Young Douglas B, Autoimmunity, microbial immunity and the immunological homunculus, 10.1016/0167-5699(91)90093-9
  2. Avrameas S, Immunology Today, 12, 154 (1991)
  3. Notkins Abner Louis, Onodera Takashi, Prabhakar Bellur, Virus-Induced Autoimmunity, Concepts in Viral Pathogenesis (1984) ISBN:9781461297567 p.210-215, 10.1007/978-1-4612-5250-4_30
  4. Allaway G. P., Srinivasappa J., Miller F. W., Prabhakar B. S., Notkins A. L., Spontaneously Proliferating Human B Lymphocytes Make Autoantibodies, 10.1093/infdis/157.5.968
  5. Coutelier Jean-Paul, Van Snick Jacques, Isotypically restricted activation of B lymphocytes by lactic dehydrogenase virus, 10.1002/eji.1830150308
  6. COUTELIER J, VANDERLOGT J, HEESSEN F, Rheumatoid factor production and polyclonal non-antiviral antibody responses elicited by infection with common mouse viruses, 10.1016/s0896-8411(05)80035-6
  7. Cafruny W. A., Hovinen D. E., Infection of Mice with Lactate Dehydrogenase-elevating Virus Leads to Stimulation of Autoantibodies, 10.1099/0022-1317-69-3-723
  8. Lymberi Peggy, Blancher Antoine, Calvas Patrick, Avrameas Stratis, Natural autoantibodies in nude and normal outbred (Swiss) and inbred (BALBc) mice, 10.1016/0896-8411(89)90270-9
  9. Notkins A. L., ELEVATED gamma-GLOBULIN AND INCREASED ANTIBODY PRODUCTION IN MICE INFECTED WITH LACTIC DEHYDROGENASE VIRUS, 10.1084/jem.123.2.347
  10. Coutelier J. P., Virally induced modulation of murine IgG antibody subclasses, 10.1084/jem.168.6.2373
  11. Coutelier J-P, J. Immunol., 147, 1383 (1991)
  12. Lutz H. U., Bussolino F., Flepp R., Fasler S., Stammler P., Kazatchkine M. D., Arese P., Naturally occurring anti-band-3 antibodies and complement together mediate phagocytosis of oxidatively stressed human erythrocytes., 10.1073/pnas.84.21.7368
  13. Cox K. O., Howles Anne, Induction and Regulation of Autoimmune Hemolytic Anemia in Mice, 10.1111/j.1600-065x.1981.tb00338.x
  14. NAYSMITH J. D., ORTEGA-PIERRES MARIA G., ELSON C. J., Rat Erythrocyte-Induced Anti-Erythrocyte Autoantibody Production and Control in Normal Mice, 10.1111/j.1600-065x.1981.tb00339.x
  15. Cox KO, Clin. exp. Immunol., 17, 319 (1974)
  16. Milich David R., Gershwin M.Eric, Murine autoimmune hemolytic anemia induced via xenogeneic erythrocyte immunization, 10.1016/0090-1229(79)90138-7
  17. Cox KO, Clin. exp. Immunol., 27, 560 (1977)
  18. Milich David R., Gershwin M.Eric, Murine autoimmune hemolytic anemia induced via xenogeneic erythrocyte immunization, 10.1016/0090-1229(79)90139-9
  19. Broomhall KS, J. Exp. Pathol., 3, 259 (1987)
  20. Vella Anthony T., Pfau Charles J., The Presence of an Anti-Erythrocyte Autoantibody in C3HeB/FeJ mice after Lymphocytic Choriomeningitis Virus Infection, 10.3109/08916939108997134
  21. Stellrecht Kathleen A., Vella Anthony T., Evidence for polyclonal B cell activation as the mechanism for LCMV-induced autoimmune hemolytic anemia, 10.1016/0165-2478(92)90126-9
  22. Coutelier Jean-Paul, Enhancement of IgG production elicited in mice by treatment with anti-CD8 antibody, 10.1002/eji.1830211046
  23. Coutelier J-P., van Roost E., Lambotte P., van Snick J., The Murine Antibody Response to Lactate Dehydrogenase-elevating Virus, 10.1099/0022-1317-67-6-1099
  24. Marsden C.H., Simmonds R.G., Purification of mouse haptoglobin by antibody affinity chromatography and development of an ELISA to measure serum haptoglobin levels, 10.1016/0022-1759(88)90402-4
  25. Rowson K. E. K., Mahy B. W. J., Lactate Dehydrogenase-elevating Virus, 10.1099/0022-1317-66-11-2297
  26. Michaelides Maria C., Simms Ernest S., Immune responses in mice infected with lactic dehydrogenase virus, 10.1016/0008-8749(80)90280-4
  27. Isakov N, J. Immunol., 128, 969 (1982)
  28. Day Michael J., Russell Jackie, Kitwood Alison J., Ponsford Mary, Elson Christopher J., Expression and regulation of erythrocyte auto-antibodies in mice following immunization with rat erythrocytes, 10.1002/eji.1830190503
  29. Walker K.Z., Gibson J., Basten A., Clonal analysis of autoreactive B cells in a murine model of autoimmune hemolytic anemia, 10.1016/0008-8749(87)90282-6
  30. COOKE A., HUTCHINGS P. R., PLAYFAIR J. H. L., Suppressor T cells in experimental autoimmune haemolytic anaemia, 10.1038/273154a0
Bibliographic reference Verdonck, Elise ; Pfau, Charles J. ; Gonzalez, Maria-Dolores ; Masson, Pierre ; Coutelier, Jean-Paul. Influence of viral infection on anti-erythrocyte autoantibody response after immunization of mice with rat red blood cells. In: Autoimmunity, Vol. 17, no. 1, p. 73-81 (1994)
Permanent URL http://hdl.handle.net/2078.1/11982