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Calcium antagonists and vasodilatation

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Godfraind, Theophile [UCL]

Calcium antagonists comprise a diverse group of chemically unrelated agents that interact with voltage-operated calcium channels (L-type) and thereby inhibit smooth muscle contractility. They are used to treat several major cardiovascular disorders, including hypertension and angina pectoris; they are also studied in congestive heart failure and in atherosclerosis. The current view is that their therapeutic action is related to vasodilatation. This view is an oversimplification, as will be shown in this review. It will also be illustrated that all calcium antagonists are not identical pharmacological agents.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1994
Journal information "Pharmacology & Therapeutics" - Vol. 64, no. 1, p. 37-75 (1994)
Peer reviewed yes
Publisher Elsevier Inc. (Philadelphia)
issn 0163-7258
e-issn 1879-016X
Publication status Publié
Affiliation UCL - MD/FSIO - Département de physiologie et pharmacologie
MESH Subject Animals ; Binding Sites ; Calcium - antagonists & inhibitors - metabolism ; Calcium Channel Agonists - pharmacology ; Calcium Channel Blockers - classification - metabolism - pharmacology ; Calcium Channels - chemistry - drug effects - metabolism ; Humans ; Membrane Potentials ; Muscle Contraction - drug effects ; Muscle, Smooth, Vascular - drug effects ; Vasodilation - drug effects
Keywords Calcium antagonists ; Calcium-channel blockers ; Calcium channels pharmacology ; Classification of calcium antagonists ; Calcium antagonists and hypertension ; Tissue selectivity of calcium antagonists
Links
Bibliographic reference Godfraind, Theophile. Calcium antagonists and vasodilatation. In: Pharmacology & Therapeutics, Vol. 64, no. 1, p. 37-75 (1994)
Permanent URL http://hdl.handle.net/2078.1/11939