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Decrease of serotonin-S2 receptors in temporal cortex of patients with Parkinson's disease and progressive supranuclear palsy.

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Maloteaux, Jean-Marie [UCL] Laterre, Emile-Christian [UCL] Laduron, P M Javoy-Agid, F Agid, Y.

The number of serotonin-S2 receptors was decreased in the temporal cortex of patients with Parkinson's disease and progressive supranuclear palsy (PSP). There was no significant modification of these receptors in the frontal cortex or in the hippocampus and putamen in both diseases. The decrease in number of receptors in PSP was unexpected, because the cerebral cortex is thought to be spared in this disease. There was no correlation between the decrease in number of serotonin-S2 receptors and the degree of dementia in Parkinson's disease, suggesting that these receptors are not directly involved in the deterioration of cognitive functions.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Publication date 1988
Journal information "Movement disorders : official journal of the Movement Disorder Society" - Vol. 3, no. 3, p. 255-62 (1988)
Peer reviewed yes
issn 0885-3185
Affiliation UCL
MESH Subject Aged ; Aged, 80 and over ; Dementia - metabolism ; Humans ; Ketanserin - metabolism ; Middle Aged ; Parkinson Disease - metabolism ; Receptors, Serotonin - analysis ; Supranuclear Palsy, Progressive - metabolism ; Temporal Lobe - metabolism
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Bibliographic reference Maloteaux, Jean-Marie ; Laterre, Emile-Christian ; Laduron, P M ; Javoy-Agid, F ; Agid, Y.. Decrease of serotonin-S2 receptors in temporal cortex of patients with Parkinson's disease and progressive supranuclear palsy.. In: Movement disorders : official journal of the Movement Disorder Society, Vol. 3, no. 3, p. 255-62 (1988)
Permanent URL http://hdl.handle.net/2078.1/11739