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In-111 transferrin scintigraphy in cirrhosis with hypoalbuminemia: Evidence for protein-losing enteropathy in a small group of selected cases.

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Dahlqvist, Géraldine [UCL] Jamar, François [UCL] Zech, Francis [UCL] Geubel, André [UCL]

Abstract Background. Hypoalbuminemia commonly observed in cirrhosis is considered to be mainly related to hepatocellular dysfunction. However, the correlation between the decrease in serum albumin and liver function is far from linear and arguments in favor of an additive role of protein-losing enteropathy have been brought by a few studies. Aim. To assess the potential role of protein-losing enteropathy in a group of patients with cirrhosis, portal hypertension, and hypoalbuminemia. Design and methods. Eleven patients with documented cirrhosis, portal hypertension, and a low serum albumin level compared to liver function underwent an (111)In-transferrin scintigraphy. Results. Using this sensitive method of investigation, nine exhibited features suggestive of exudative enteropathy. Serum albumin level and digestive protein loss were even correlated (Pearson's coefficient = -0.529, one-sided p = 0.047). Protein loss were however not correlated with the degree of portal hypertension or with the extent of liver dysfunction evaluated by the aminopyrine breath test. Conclusions. Our preliminary data obtained in a small group of selected patients with cirrhosis, portal hypertension, and hypoalbuminemia indicate that protein-losing enteropathy may represent an appreciable and underestimated cause of hypoproteinemia.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2012
Language Anglais
Journal information "Scandinavian Journal of Gastroenterology" - Vol. 47, no. 10, p. 1247-1452 (2012)
Peer reviewed yes
Publisher Informa Healthcare ((United Kingdom) London)
issn 0036-5521
e-issn 1502-7708
Publication status Publié
Affiliations UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie
UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie
UCL - (SLuc) Service de médecine nucléaire
UCL - (SLuc) Service de médecine interne et maladies infectieuses (MIMI)
UCL - (SLuc) Service d'hépato-gastro-entérologie
Links
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Bibliographic reference Dahlqvist, Géraldine ; Jamar, François ; Zech, Francis ; Geubel, André. In-111 transferrin scintigraphy in cirrhosis with hypoalbuminemia: Evidence for protein-losing enteropathy in a small group of selected cases.. In: Scandinavian Journal of Gastroenterology, Vol. 47, no. 10, p. 1247-1452 (2012)
Permanent URL http://hdl.handle.net/2078.1/116581