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Spontaneous rhythmic contractions of human saphenous veins isolated from old subjects are sensitive to cyclooxygenase inhibitors

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Schoeffter, P. Godfraind, Theophile [UCL]

Spontaneous rhythmic contractions were observed in some preparations of human isolated saphenous veins from old (greater than 60 years) subjects. These contractions were insensitive to adrenergic and histaminergic blockers, but were abolished by the cyclooxygenase inhibitors, aspirin and indomethacin, indicating the participation of endogenous eicosanoids.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1989
Journal information "Experientia" - Vol. 45, no. 5, p. 459-461 (1989)
Peer reviewed yes
Publisher Birkhaeuser Verlag AG
issn 0014-4754
Publication status Publié
Affiliation UCL
MESH Subject Adult ; Aged ; Aging ; Aspirin - pharmacology ; Coronary Artery Bypass ; Cyclooxygenase Inhibitors ; Female ; Histamine - pharmacology ; Humans ; Indomethacin - pharmacology ; Male ; Middle Aged ; Muscle Contraction - drug effects ; Muscle Development ; Muscle, Smooth - drug effects - growth & development - physiopathology ; Nifedipine - pharmacology ; Norepinephrine - pharmacology ; Phentolamine - pharmacology ; Prazosin - pharmacology ; Pyrilamine - pharmacology ; Saphenous Vein - drug effects - growth & development - physiopathology
Keywords Human saphenous vein ; Spontaneous rhythmic contractions ; Cyclooxygenase inhibitors
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  1. Acknowledgments. The authors are indebted to Dr R. Dion for the supply of fragments of saphenous veins.
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Bibliographic reference Schoeffter, P. ; Godfraind, Theophile. Spontaneous rhythmic contractions of human saphenous veins isolated from old subjects are sensitive to cyclooxygenase inhibitors. In: Experientia, Vol. 45, no. 5, p. 459-461 (1989)
Permanent URL http://hdl.handle.net/2078.1/11566