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Comparative pharmacology of cardiac and vascular tissues in heart failure

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Godfraind, Theophile [UCL]

The purpose of this paper is to review various factors of the control of cardiac contractility and of vascular tone that may be altered in heart failure and that are targets for pharmacotherapeutic interventions. This paper is divided into three main sections: pathophysiological aspects of heart failure, differences in the regulation of cardiac contraction and of vascular tone, and pharmacological principles in the management of heart failure.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1989
Journal information "Journal of Cardiovascular Pharmacology" - Vol. 14, no. Suppl 8, p. S1-S20 (1989)
Peer reviewed yes
Publisher Lippincott Williams & Wilkins (Philadelphia)
issn 0160-2446
e-issn 1533-4023
Publication status Publié
Affiliation UCL
MESH Subject Adrenergic beta-Agonists - pharmacology ; Animals ; Blood Vessels - drug effects - metabolism - physiopathology ; Calcium - metabolism - physiology ; Calcium Channel Blockers - pharmacology ; Calcium Channels - drug effects - metabolism ; Cardiac Glycosides - pharmacology ; Cardiac Output - drug effects ; Cardiovascular Agents - pharmacology - therapeutic use ; Guinea Pigs ; Heart - drug effects - physiopathology ; Heart Failure - drug therapy - metabolism - physiopathology ; Humans ; Muscle, Smooth - drug effects - metabolism ; Myocardial Contraction - drug effects ; Myocardium - metabolism ; Rats ; Vasoconstriction - drug effects
Keywords Heart failure ; Inotropic agents ; Calcium antagonists ; Vasodilators ; Cardiac glycosides ; Beta-adenoceptor agonists ; PDE inhibitors
Links
Bibliographic reference Godfraind, Theophile. Comparative pharmacology of cardiac and vascular tissues in heart failure. In: Journal of Cardiovascular Pharmacology, Vol. 14, no. Suppl 8, p. S1-S20 (1989)
Permanent URL http://hdl.handle.net/2078.1/11562