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Kinetics and determinants of the changes of CC16, a lung secretory protein in a rat model of toxic lung injury.

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Hantson, Philippe [UCL] Bernard, Alfred [UCL] Hermans, Cédric [UCL]

PURPOSE: To investigate the kinetics and the determinants of the changes of the Clara cell 16 kDa protein (CC16) as a marker of lung injury following exposure to different toxicants. METHODS: Rats were treated with 4-Ipomeanol (IPO), alpha-naphtylthiourea (ANTU), sodium chromate (Na(2)CrO(4)) or paraquat-(PQ). The changes of CC16, total protein, albumin, and cystatin-C were determined on BALF supernatan, and CC16, cystatin-C and creatinine levels were also determined in serum. RESULTS: Bronchiolar insult due to IPO or ANTU resulted in an initial transient increase of serum CC16, parallel to that of albumin in BALF, and a subsequent reduction in both BALF and serum. A slight reduction of CC16 in BALF was already apparent one hour following treatment with PQ. In the serum, CC16 increased to 400% of basal value. With PQ and Na(2)CrO(4), the elevation of CC16 was mainly determined by the degree of renal impairment.

Document type Article de périodique (Journal article) – Journal Article
Access type Accès restreint
Publication date 2008
Journal information "Clinical toxicology (Philadelphia, Pa.)" - Vol. 46, no. 3, p. 230-8 (2008)
Peer reviewed yes
issn 1556-3650
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - MD/ESP - Ecole de santé publique
UCL - (SLuc) Centre de toxicologie clinique
UCL - (SLuc) Service de soins intensifs
UCL - (SLuc) Centre de malformations vasculaires congénitales
UCL - (SLuc) Service d'hématologie
MESH Subject Uteroglobin - metabolism ; Rats, Sprague-Dawley ; Rats ; Lung Diseases - chemically induced - metabolism ; Kinetics ; Female ; Cystatins - metabolism ; Calibration ; Bronchoalveolar Lavage Fluid - chemistry ; Biological Markers ; Animals ; Albumins - metabolism
Links
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Bibliographic reference Hantson, Philippe ; Bernard, Alfred ; Hermans, Cédric. Kinetics and determinants of the changes of CC16, a lung secretory protein in a rat model of toxic lung injury.. In: Clinical toxicology (Philadelphia, Pa.), Vol. 46, no. 3, p. 230-8 (2008)
Permanent URL http://hdl.handle.net/2078.1/11324