User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

An active haemovigilance programme characterizing the safety profile of 7437 platelet transfusions prepared with amotosalen photochemical treatment.

Primary tabs

Osselaer, Jean-Claude [UCL] Cazenave, J P Lambermont, M. Garraud, O. Hidajat, M Defoin, Laurence [UCL] Corash, L.

BACKGROUND: An active haemovigilance programme was implemented to survey adverse events (AE) associated with transfusion of platelets photochemically treated with amotosalen and ultraviolet A (PCT-PLT). The results of 5106 transfusions have already been reported. Here we report the results of an additional 7437 PCT-PLT transfusions. METHODS: The focus of this ongoing haemovigilance programme is to document all AEs associated with PCT-PLT transfusion. Data collected for AEs include: time of event after starting transfusion, clinical descriptions, vital signs, results from radiographs and bacterial cultures, event severity (Grade 0-4) and causal relationship to PCT-PLT transfusion. RESULTS: One thousand four hundred patients (mean 60 years, range 1-96) received PCT-PLT transfusions. The majority of the patients (53.4%) had haematology-oncology diseases and required conventional chemotherapy (44.8%) or stem cell transplantation (8.6%). Sixty-eight PCT-PLT transfusions were associated with AE. Acute transfusion reactions (ATR), classified as an AE possibly related, probably related, or related to PCT-PLT transfusions were infrequent (n = 55, 55/7437 = 0.7%) and most were of Grade 1 severity. Thirty-nine patients (39/1400 = 2.8%) experienced one or more ATRs. The most frequently reported signs/symptoms were chills, fever, urticaria, dyspnoea, nausea and vomiting. Five AEs were considered severe (> or = Grade 2); however, no causal relationship to PCT-PLT transfusion was found. Repeated exposure to PCT-PLT did not increase the likelihood of an ATR. No cases of transfusion-related acute lung injury and no deaths due to PCT-PLT transfusions were reported. CONCLUSIONS: Routine transfusion of PCT-PLT is well-tolerated in a wide range of patients. ATRs related to PCT-PLT transfusion were infrequent and most were of mild severity.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 2008
Journal information "Vox sanguinis" - Vol. 94, no. 4, p. 315-23 (2008)
Peer reviewed yes
e-issn 1423-0410
issn 0042-9007
Publication status Publié
Affiliations UCL - (MGD) Centre de transfusion sanguine
UCL - MD/MINT - Département de médecine interne
MESH Subject Ultraviolet Rays ; Psoralens - therapeutic use ; Prospective Studies ; Platelet Transfusion - adverse effects ; Photosensitizing Agents - therapeutic use ; Middle Aged ; Male ; Infant ; Humans ; Female ; Child, Preschool ; Child ; Blood Preservation - methods ; Blood Platelets ; Aged, 80 and over ; Aged ; Adult ; Adolescent
Links
  1. van Rhenen D., Transfusion of pooled buffy coat platelet components prepared with photochemical pathogen inactivation treatment: the euroSPRITE trial, 10.1182/blood-2002-03-0932
  2. McCullough J., Therapeutic efficacy and safety of platelets treated with a photochemical process for pathogen inactivation: the SPRINT Trial, 10.1182/blood-2003-12-4443
  3. Janetzko Karin, Cazenave Jean-Pierre, Kluter Harald, Kientz Daniel, Michel Martine, Beris Photis, Lioure Bruno, Hastka Jan, Marblie Stephane, Mayaudon Veronique, Lin Lily, Lin Jin-Sying, Conlan Maureen G., Flament Jocelyne, Therapeutic efficacy and safety of photochemically treated apheresis platelets processed with an optimized integrated set, 10.1111/j.1537-2995.2005.00550.x
  4. Osselaer J, Transfusion (2008)
  5. Garraud O, Vox Sang, 93, 32 (2007)
  6. Klein Harvey G., Anderson David, Bernardi Marie-Josée, Cable Ritchard, Carey William, Hoch Jeffrey S., Robitaille Nancy, Sivilotti Marco L.A., Smaill Fiona, Pathogen inactivation: making decisions about new technologies. : Report of a consensus conference, 10.1111/j.1537-2995.2007.01512.x
  7. Andreu Georges, Morel Pascal, Forestier Francois, Debeir Joelle, Rebibo Danielle, Janvier Gerard, Herve Patrick, Hemovigilance network in France: organization and analysis of immediate transfusion incident reports from 1994 to 1998, 10.1046/j.1537-2995.2002.00202.x
  8. Faber JC, Blood Transfusion in Europe, 213 (2005)
  9. Corash L, Lin L, Novel processes for inactivation of leukocytes to prevent transfusion-associated graft-versus-host disease, 10.1038/sj.bmt.1704284
  10. Chambers LA, Kruskall MS, Pacini DG, Donovan LM, Febrile reactions after platelet transfusion: the effect of single versus multiple donors, 10.1046/j.1537-2995.1990.30390194340.x
  11. Heddle Nancy M., Klama Luba, Singer Joel, Richards Carl, Fedak Paul, Walker Irwin, Kelton John G., The Role of the Plasma from Platelet Concentrates in Transfusion Reactions, 10.1056/nejm199409083311001
  12. Mangano Mark M., Chambers Linda A., KruskalL Margot S., Limited Efficacy of Leukopoor Platelets for Prevention of Febrile Transfusion Reactions, 10.1093/ajcp/95.5.733
  13. Heddle NM, Klama LN, Griffith L, Roberts R, Shukla G, Kelton JG, A prospective study to identify the risk factors associated with acute reactions to platelet and red cell transfusions, 10.1046/j.1537-2995.1993.331094054613.x
  14. Enright Helen, Davis Kathryn, Gernsheimer Terry, McCullough Jeffrey J., Woodson Robert, Slichter Sherrill J., Factors influencing moderate to severe reactions to PLT transfusions: experience of the TRAP multicenter clinical trial, 10.1046/j.1537-2995.2003.00529.x
  15. Isola H, Vox Sang, 93, 165 (2007)
  16. Kerkhoffs J.-L. H., Eikenboom J. C., Schipperus M. S., van Wordragen-Vlaswinkel R. J., Brand R., Harvey M. S., de Vries R. R., Barge R., van Rhenen D. J., Brand A., A multicenter randomized study of the efficacy of transfusions with platelets stored in platelet additive solution II versus plasma, 10.1182/blood-2006-04-020131
  17. de Wildt-Eggen J., Nauta S., Schrijver J.G., van Marwijk Kooy M., Bins M., van Prooijen H.C., Reactions and platelet increments after transfusion of platelet concentrates in plasma or an additive solution: a prospective, randomized study, 10.1046/j.1537-2995.2000.40040398.x
  18. Heddle Nancy M., Blajchman Morris A., Meyer Ralph M., Lipton Jeff H., Walker Irwin R., Sher Graham D., Constantini Lorrie A., Patterson Bruce, Roberts Robin S., Thorpe Kevin E., Levine Mark N., A randomized controlled trial comparing the frequency of acute reactions to plasma-removed platelets and prestorage WBC-reduced platelets, 10.1046/j.1537-2995.2002.00094.x
Bibliographic reference Osselaer, Jean-Claude ; Cazenave, J P ; Lambermont, M. ; Garraud, O. ; Hidajat, M ; et. al. An active haemovigilance programme characterizing the safety profile of 7437 platelet transfusions prepared with amotosalen photochemical treatment.. In: Vox sanguinis, Vol. 94, no. 4, p. 315-23 (2008)
Permanent URL http://hdl.handle.net/2078.1/11277