Momtaz, Maryam
[UCL]
Rerat, Vincent
[UCL]
Gharbi, Sonia
[UCL]
Gerard, Estelle
[UCL]
Pourcelle, Vincent
[UCL]
Marchand-Brynaert, Jacqueline
[UCL]
A graftable LDV (Leu-Asp-Val) peptidomimetic molecule (B-c) has been prepared from 3-(5-amino-2-hydroxy)phenyl-propionic acid, as alpha(4)beta(1) (VLA-4) integrin ligand. For that purpose, the mechanism of 3-(4-azidophenyl)propionic acid rearrangement has been revisited. Activation of Durapore DVPP-hydrophilic membrane, by surface wet chemistry using triazine trifluoride, followed by covalent coupling of B-c produced a modified filter (0.8% of derivatisation from XPS analysis) with improved capacity of leukocyte retention.
Bibliographic reference |
Momtaz, Maryam ; Rerat, Vincent ; Gharbi, Sonia ; Gerard, Estelle ; Pourcelle, Vincent ; et. al. A graftable LDV peptidomimetic: design, synthesis and application to a blood filtration membrane.. In: Bioorganic & medicinal chemistry letters, Vol. 18, no. 3, p. 1084-90 (2008) |
Permanent URL |
http://hdl.handle.net/2078.1/11236 |