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Expression of focal adhesion kinase in small-cell lung carcinoma.

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Ocak, Sebahat [UCL] Chen, Heidi [] Callison, Clay [] Gonzalez, Adriana L [] Massion, Pierre P []

The focal adhesion kinase (FAK) is a non-receptor tyrosine kinase linked to tumor growth, invasion, and metastasis. FAK is overexpressed and associated with prognosis in many cancers, but its prognostic value in small-cell lung carcinoma (SCLC) is unknown and was the focus of this study.

Document type Article de périodique (Journal article) – Evaluation Studies, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.
Access type Accès mixte
Publication date 2012
Language Anglais
Journal information "Cancer" - Vol. 118, no. 5, p. 1293-301 (2012)
Peer reviewed yes
e-issn 1097-0142
Publication status Publié
Affiliations UCL - (MGD) Service de pneumologie
UCL - SSS/IREC/MONT - Pôle Mont Godinne
MESH Subject Aged ; Female ; Paxillin - metabolism ; Phosphorylation ; Small Cell Lung Carcinoma - diagnosis, genetics, metabolism, mortality ; Survival Analysis ; Focal Adhesion Kinase 1 - genetics, metabolism ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms - diagnosis, genetics, metabolism, mortality ; Male ; Middle Aged ; Neoplasm Staging
Links
  1. Jemal A., Siegel R., Ward E., Hao Y., Xu J., Thun M. J., Cancer Statistics, 2009, 10.3322/caac.20006
  2. Jackman David M, Johnson Bruce E, Small-cell lung cancer, 10.1016/s0140-6736(05)67569-1
  3. Cheng Susanna, Evans William K., Stys-Norman Denise, Shepherd Frances A., Chemotherapy for Relapsed Small Cell Lung Cancer: A Systematic Review and Practice Guideline, 10.1097/01.jto.0000263720.15062.51
  4. Murray Nevin, Turrisi Andrew T., A Review of First-Line Treatment for Small-cell Lung Cancer, 10.1016/s1556-0864(15)31579-3
  5. von Pawel Joachim, Schiller Joan H., Shepherd Frances A., Fields Scott Z., Kleisbauer J.P., Chrysson Nick G., Stewart David J., Clark Peter I., Palmer Martin C., Depierre Alain, Carmichael James, Krebs Jacqueline B., Ross Graham, Lane Stephen R., Gralla Richard, Topotecan Versus Cyclophosphamide, Doxorubicin, and Vincristine for the Treatment of Recurrent Small-Cell Lung Cancer, 10.1200/jco.1999.17.2.658
  6. Ettinger David S., Berkey Brian A., Abrams Ross A., Fontanesi James, Machtay Mitchell, Duncan Philip J., Curran Walter J., Movsas Benjamin, Byhardt Roger W., Study of Paclitaxel, Etoposide, and Cisplatin Chemotherapy Combined With Twice-Daily Thoracic Radiotherapy for Patients With Limited-Stage Small-Cell Lung Cancer: A Radiation Therapy Oncology Group 9609 Phase II Study, 10.1200/jco.2005.00.414
  7. Kubota K., Pilot Study of Concurrent Etoposide and Cisplatin Plus Accelerated Hyperfractionated Thoracic Radiotherapy Followed by Irinotecan and Cisplatin for Limited-Stage Small Cell Lung Cancer: Japan Clinical Oncology Group 9903, 10.1158/1078-0432.ccr-04-1771
  8. Murren, Small Cell Lung Cancer (2001)
  9. Hanks Steven K, Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility, 10.2741/1114
  10. Parsons J. T., Focal adhesion kinase: the first ten years, 10.1242/jcs.00373
  11. Mitra Satyajit K., Hanson Daniel A., Schlaepfer David D., Focal adhesion kinase: in command and control of cell motility, 10.1038/nrm1549
  12. Siesser P. M.F., The Signaling and Biological Implications of FAK Overexpression in Cancer, 10.1158/1078-0432.ccr-06-0456
  13. Gabarra-Niecko Veronica, 10.1023/a:1023725029589
  14. Parsons J. T., Slack-Davis J., Tilghman R., Roberts W. G., Focal Adhesion Kinase: Targeting Adhesion Signaling Pathways for Therapeutic Intervention, 10.1158/1078-0432.ccr-07-2220
  15. Tilghman Robert W., Parsons J. Thomas, Focal adhesion kinase as a regulator of cell tension in the progression of cancer, 10.1016/j.semcancer.2007.08.002
  16. Roberts W. G., Ung E., Whalen P., Cooper B., Hulford C., Autry C., Richter D., Emerson E., Lin J., Kath J., Coleman K., Yao L., Martinez-Alsina L., Lorenzen M., Berliner M., Luzzio M., Patel N., Schmitt E., LaGreca S., Jani J., Wessel M., Marr E., Griffor M., Vajdos F., Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271, 10.1158/0008-5472.can-07-5155
  17. Shi Qing, Hjelmeland Anita B., Keir Stephen T., Song Linhua, Wickman Sarah, Jackson Dowdy, Ohmori Osamu, Bigner Darell D., Friedman Henry S., Rich Jeremy N., A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth, 10.1002/mc.20297
  18. Slack-Davis Jill K., Martin Karen H., Tilghman Robert W., Iwanicki Marcin, Ung Ethan J., Autry Christopher, Luzzio Michael J., Cooper Beth, Kath John C., Roberts W. Gregory, Parsons J. Thomas, Cellular Characterization of a Novel Focal Adhesion Kinase Inhibitor, 10.1074/jbc.m606695200
  19. Siu, Journal of Clinical Oncology., 25, 3527 (2007)
  20. Carelli Stephana, Zadra Giorgia, Vaira Valentina, Falleni Monica, Bottiglieri Luca, Nosotti Mario, Di Giulio Anna Maria, Gorio Alfredo, Bosari Silvano, Up-regulation of focal adhesion kinase in non-small cell lung cancer, 10.1016/j.lungcan.2006.06.001
  21. Hsu, Oncol Rep., 18, 81 (2007)
  22. Imaizumi Munehisa, Nishimura Masashi, Takeuchi Seijiro, Murase Mitsuya, Hamaguchi Michinari, Role of tyrosine specific phosphorylation of cellular proteins, especially EGF receptor and p125FAK in human lung cancer cells, 10.1016/s0169-5002(97)00650-8
  23. Owens, Cancer Res., 55, 2752 (1995)
  24. Wang, Ai Zheng., 24, 1091 (2005)
  25. Zhao Jihe, Guan Jun-Lin, Signal transduction by focal adhesion kinase in cancer, 10.1007/s10555-008-9165-4
  26. Canel M., Overexpression of Focal Adhesion Kinase in Head and Neck Squamous Cell Carcinoma Is Independent of fak Gene Copy Number, 10.1158/1078-0432.ccr-05-1583
  27. Furuyama Kenichiro, Doi Ryuichiro, Mori Tomohiko, Toyoda Eiji, Ito Daisuke, Kami Kazuhiro, Koizumi Masayuki, Kida Atsushi, Kawaguchi Yoshiya, Fujimoto Koji, Clinical Significance of Focal Adhesion Kinase in Resectable Pancreatic Cancer, 10.1007/s00268-005-0165-z
  28. Gabriel B., Weak Expression of Focal Adhesion Kinase (pp125FAK) in Patients with Cervical Cancer Is Associated with Poor Disease Outcome, 10.1158/1078-0432.ccr-05-1867
  29. Itoh S., Role of Expression of Focal Adhesion Kinase in Progression of Hepatocellular Carcinoma, 10.1158/1078-0432.ccr-1046-03
  30. Miyazaki T, Kato H, Nakajima M, Sohda M, Fukai Y, Masuda N, Manda R, Fukuchi M, Tsukada K, Kuwano H, FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma, 10.1038/sj.bjc.6601050
  31. Recher Christian, Ysebaert Loïc, Beyne-Rauzy Odile, Mansat-De Mas Véronique, Ruidavets Jean-Bernard, Cariven Pascal, Demur Cécile, Payrastre Bernard, Laurent Guy, Racaud-Sultan Claire, Expression of Focal Adhesion Kinase in Acute Myeloid Leukemia Is Associated with Enhanced Blast Migration, Increased Cellularity, and Poor Prognosis, 10.1158/0008-5472.can-03-3005
  32. Schmitz Klaus Jürgen, Grabellus Florian, Callies Rainer, Otterbach Friedrich, Wohlschlaeger Jeremias, Levkau Bodo, Kimmig Rainer, Schmid Kurt Werner, Baba Hideo Andreas, High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome, 10.1186/bcr977
  33. Theocharis S.E, Kouraklis G.P, Kakisis J.D, Kanelli H.G, Apostolakou F.E, Karatzas G.M, Koutselinis A.S, Focal adhesion kinase expression is not a prognostic predictor in colon adenocarcinoma patients, 10.1016/s0748-7983(03)00120-3
  34. Wang Changli, Yang Ran, Yue Dongsheng, Zhang Zhenfa, Expression of FAK and PTEN in Bronchioloalveolar Carcinoma and Lung Adenocarcinoma, 10.1007/s00408-008-9130-6
  35. Ocak S, Yamashita H, Udyavar A R, Miller A N, Gonzalez A L, Zou Y, Jiang A, Yi Y, Shyr Y, Estrada L, Quaranta V, Massion P P, DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway, 10.1038/onc.2010.362
  36. Kononen Juha, Bubendorf Lukas, Kallionimeni Anne, Bärlund Maarit, Schraml Peter, Leighton Stephen, Torhorst Joachim, Mihatsch Michael J, Sauter Guido, Kallionimeni Olli-P., Tissue microarrays for high-throughput molecular profiling of tumor specimens, 10.1038/nm0798-844
  37. Massion, Cancer Res., 62, 3636 (2002)
  38. Team, R: a language and environment for statistical computing (2005)
  39. Ihde, Am Rev Respir Dis., 123, 500 (1981)
  40. Weiner T.M, Craven R.J, Cance W.G, Liu Et, Expression of focal adhesion kinase gene and invasive cancer, 10.1016/0140-6736(93)92881-s
  41. Cance, Clin Cancer Res., 6, 2417 (2000)
  42. Rovin Joshua D., Frierson Henry F., Ledinh Wayne, Parsons J. Thomas, Adams Reid B., Expression of focal adhesion kinase in normal and pathologic human prostate tissues, 10.1002/pros.10114
  43. Ayaki, Clin Cancer Res., 7, 3106 (2001)
  44. Kahana Orlie, Micksche Michael, Witz Isaac P, Yron Ilana, The focal adhesion kinase (P125FAK) is constitutively active in human malignant melanoma, 10.1038/sj.onc.1205472
  45. Maung Kavita, Easty David J, Hill Simon P, Bennett Dorothy C, Requirement for focal adhesion kinase in tumor cell adhesion, 10.1038/sj.onc.1203094
  46. Moon H.-S., Park W. I., Choi E.-A., Chung H.-W., Kim S.-C., The expression and tyrosine phosphorylation of E-cadherin/catenin adhesion complex, and focal adhesion kinase in invasive cervical carcinomas, 10.1046/j.1525-1438.2003.13396.x
  47. McCormack Stephen J, Brazinski Scott E, Jr James L Moore, Werness Bruce A, Goldstein David J, Activation of the focal adhesion kinase signal transduction pathway in cervical carcinoma cell lines and human genital epithelial cells immortalized with human papillomavirus type 18, 10.1038/sj.onc.1201186
Bibliographic reference Ocak, Sebahat ; Chen, Heidi ; Callison, Clay ; Gonzalez, Adriana L ; Massion, Pierre P. Expression of focal adhesion kinase in small-cell lung carcinoma.. In: Cancer, Vol. 118, no. 5, p. 1293-301 (2012)
Permanent URL http://hdl.handle.net/2078.1/111520