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Fatty acid amide hydrolase: from characterization to therapeutics.

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Labar, Geoffray [UCL] Michaux, Catherine [UCL]

Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme within the amidase-signature family that terminates the action of several endogenous lipid messengers, including oleamide and the endocannabinoid anandamide. The hydrolysis of such messengers leads to molecules devoid of biological activity, and, therefore, modulates a number of neurobehavioral processes in mammals, including pain, sleep, feeding, and locomotor activity. Investigations into the structure and function of FAAH, its biological and therapeutic implications, as well as a description of different families of FAAH inhibitors are the topic of this review.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2007
Journal information "Chemistry & biodiversity" - Vol. 4, no. 8, p. 1882-1902 (2007)
Peer reviewed yes
issn 0441-3776
e-issn 1612-1880
Publication status Publié
Affiliation UCL - MD/FARM - Ecole de pharmacie
MESH Subject Amidohydrolases - antagonists & inhibitors - chemistry - physiology ; Animals ; Chemistry, Pharmaceutical ; Crystallography, X-Ray ; Endocannabinoids - metabolism ; Humans ; Models, Molecular ; Obesity - enzymology ; Substance-Related Disorders - enzymology
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Bibliographic reference Labar, Geoffray ; Michaux, Catherine. Fatty acid amide hydrolase: from characterization to therapeutics.. In: Chemistry & biodiversity, Vol. 4, no. 8, p. 1882-1902 (2007)
Permanent URL http://hdl.handle.net/2078.1/11077