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Influence of interhemispheric interactions on motor function in chronic stroke

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Murase, Nagako Duque, Julie [UCL] Mazzocchio, Riccardo Cohen, Leonardo G

In patients with chronic stroke, the primary motor cortex of the intact hemisphere (M1(intact hemisphere)) may influence functional recovery, possibly through transcallosal effects exerted over M1 in the lesioned hemisphere (M1(lesioned hemisphere)). Here, we studied interhemispheric inhibition (IHI) between M1(intact hemisphere) and M1(lesioned hemisphere) in the process of generation of a voluntary movement by the paretic hand in patients with chronic subcortical stroke and in healthy volunteers. IHI was evaluated in both hands preceding the onset of unilateral voluntary index finger movements (paretic hand in patients, right hand in controls) in a simple reaction time paradigm. IHI at rest and shortly after the Go signal were comparable in patients and controls. Closer to movement onset, IHI targeting the moving index finger turned into facilitation in controls but remained deep in patients, a finding that correlated with poor motor performance. These results document an abnormally high interhemispheric inhibitory drive from M1(intact hemisphere) to M1(lesioned hemisphere) in the process of generation of a voluntary movement by the paretic hand. It is conceivable that this abnormality could adversely influence motor recovery in some patients with subcortical stroke, an interpretation consistent with models of interhemispheric competition in motor and sensory systems.

Document type Article de périodique (Journal article) – Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.
Access type Accès restreint
Publication date 2004
Language Anglais
Journal information "Annals of Neurology" - Vol. 55, no. 3, p. 400-9 (2004)
Peer reviewed yes
Publisher JohnWiley & Sons, Inc. ((United States) Hoboken)
issn 0364-5134
e-issn 1531-8249
Publication status Publié
Affiliation UCL - MD/FSIO - Département de physiologie et pharmacologie
MESH Subject Adult ; Aged ; Functional Laterality ; Humans ; Male ; Middle Aged ; Motor Activity - physiology ; Motor Cortex - physiology ; Movement ; Paresis - etiology, physiopathology ; Psychomotor Performance ; Reaction Time ; Case-Control Studies ; Recovery of Function - physiology ; Stroke - physiopathology ; Time Factors ; Chronic Disease ; Conditioning (Psychology) ; Electric Stimulation - methods ; Electromyography - methods ; Evoked Potentials, Motor - physiology, radiation effects ; Female ; Fingers - physiology
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Bibliographic reference Murase, Nagako ; Duque, Julie ; Mazzocchio, Riccardo ; Cohen, Leonardo G. Influence of interhemispheric interactions on motor function in chronic stroke. In: Annals of Neurology, Vol. 55, no. 3, p. 400-9 (2004)
Permanent URL http://hdl.handle.net/2078.1/109995