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Dissociation between manipulation and conceptual knowledge of object use in the supramarginalis gyrus

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Pelgrims, Barbara [UCL] Olivier, Etienne [UCL] Andres, Michael [UCL]

Because tool naming activates motor-related areas in the posterior parietal cortex, it has been suggested that conceptual knowledge of tools relies on their unique manipulation patterns. However, this view is questioned by the finding that some patients impaired in retrieving manipulation knowledge of man-made objects are still able to perform conceptual judgments on them. To address this issue, we used repetitive transcranial magnetic stimulation (rTMS) to interfere with the functioning of the anterior part of the right or left supramarginalis gyrus (SMG), a region critically involved in object-directed actions. rTMS was delivered in healthy participants performing four judgment tasks designed to explore different aspects of manipulation and conceptual knowledge of man-made objects. The two manipulation judgment tasks consisted in determining whether (1) two objects displayed on a computer screen are normally used by adopting a comparable hand posture, or (2) a given hand posture is appropriate to use an object. In the two conceptual judgment tasks, subjects had to decide whether (1) two objects displayed on the computer screen are normally used in the same context or (2) they are functionally related. We found that virtual lesions of left SMG interfere only with the performance of the manipulation judgment task in which subjects had to decide whether two different objects are used by adopting the same hand posture, all the other tasks being unaltered. rTMS applied over the right SMG had no effect. These results challenge the assumption that conceptual knowledge of tools is grounded upon motor representations.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2011
Language Anglais
Journal information "Human Brain Mapping" - Vol. 32, no. 11, p. 1802-1810 (2011)
Peer reviewed yes
Publisher JohnWiley & Sons, Inc. ((United States) Hoboken)
issn 1065-9471
e-issn 1097-0193
Publication status Publié
Affiliations UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience
UCL - SSS/IONS - Institute of NeuroScience
UCL - SSH/IPSY - Psychological Sciences Research Institute
MESH Subject Adult ; Data Interpretation, Statistical ; Mental Processes ; Mirror Neurons - physiology ; Parietal Lobe - physiology ; Photic Stimulation ; Psychomotor Performance - physiology ; Reaction Time - physiology ; Tool Use Behavior ; Transcranial Magnetic Stimulation ; Young Adult ; Efferent Pathways - physiology ; Female ; Functional Laterality - physiology ; Hand - innervation, physiology ; Humans ; Judgment ; Knowledge ; Male
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Bibliographic reference Pelgrims, Barbara ; Olivier, Etienne ; Andres, Michael. Dissociation between manipulation and conceptual knowledge of object use in the supramarginalis gyrus. In: Human Brain Mapping, Vol. 32, no. 11, p. 1802-1810 (2011)
Permanent URL http://hdl.handle.net/2078.1/109817