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Optimal assessment of the ability of children with recurrent respiratory tract infections to produce anti-polysaccharide antibodies.

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Tuerlinckx, David [UCL] Vermeulen, Francois Pékus, V [UCL] de Bilderling, Georges [UCL] Glupczynski, Y. [UCL] Collet, Stéphanie [UCL] Jamart, Jacques [UCL] Bodart, Eddy [UCL] Mascart, F

Specific anti-polysaccharide antibody deficiency (SPAD) is an immune disorder. Diagnostic criteria have not yet been defined clearly. One hundred and seventy-six children evaluated for recurrent respiratory tract infections were analysed retrospectively. For each subject, specific anti-pneumococcal antibodies had been measured with two enzyme-linked immunosorbent assays (ELISAs), one overall assay (OA) using the 23-valent pneumococcal polysaccharide vaccine (23-PPSV) as detecting antigen and the other purified pneumococcal polysaccharide serotypes (serotype-specific assay, SSA) (serotypes 14, 19F and 23F). Antibody levels were measured before (n = 176) and after (n = 93) immunization with the 23-PPSV. Before immunization, low titres were found for 138 of 176 patients (78%) with OA, compared to 20 of 176 patients (11%) with the SSA. We found a significant correlation between OA and SSA results. After immunization, 88% (71 of 81) of the patients considered as responders in the OA test were also responders in the SSA; 93% (71 of 76) of the patients classified as responders according to the SSA were also responders in the OA. SPAD was diagnosed in 8% (seven of 93) of patients on the basis of the absence of response in both tests. Thus, we propose to use OA as a screening test for SPAD before 23-PPSV immunization. After immunization, SSA should be used only in case of a low response in OA. Only the absence of or a very low antibody response detected by both tests should be used as a diagnostic criterion for SPAD.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2007
Journal information "Clinical and experimental immunology" - Vol. 149, no. 2, p. 295-302 (2007)
Peer reviewed yes
Publisher Blackwell Scientific Publications ((United Kingdom) Oxford)
issn 0009-9104
Publication status Publié
Affiliations UCL - MD/GYPE - Département de gynécologie, d'obstétrique et de pédiatrie
UCL - (MGD) Service d'oto-rhino-laryngologie
UCL - (MGD) Unité de support scientifique
UCL - (MGD) Service de pédiatrie
MESH Subject Adolescent ; Aging - immunology ; Antibodies, Bacterial - biosynthesis - blood ; Child ; Child, Preschool ; Follow-Up Studies ; Humans ; Immunization ; Immunoglobulin A - blood ; Immunoglobulin G - blood ; Immunologic Deficiency Syndromes - diagnosis - immunology ; Infant ; Pneumococcal Vaccines - immunology ; Polysaccharides, Bacterial - immunology ; Recurrence ; Respiratory Tract Infections - immunology ; Retrospective Studies
Keywords Anti-pneumococcal antibody ; Anti-polysaccharide antibody ; Pneumococcal polysaccharide vaccine ; Respiratory tract infection
Links
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Bibliographic reference Tuerlinckx, David ; Vermeulen, Francois ; Pékus, V ; de Bilderling, Georges ; Glupczynski, Y. ; et. al. Optimal assessment of the ability of children with recurrent respiratory tract infections to produce anti-polysaccharide antibodies.. In: Clinical and experimental immunology, Vol. 149, no. 2, p. 295-302 (2007)
Permanent URL http://hdl.handle.net/2078.1/10969