User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Common variants at five new loci associated with early-onset inflammatory bowel disease.

Primary tabs

download
  • Open access
  • PDF
  • 398.32 K
Imielinski, Marcin [] Baldassano, Robert N [] Griffiths, Anne [] Russell, Richard K [] Annese, Vito [] Dewit, Olivier [UCL]

The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the western world. Here we report the results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD. We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 x 10(-9)), 22q12 (rs2412973, P = 1.55 x 10(-9)), 10q22 (rs1250550, P = 5.63 x 10(-9)), 2q37 (rs4676410, P = 3.64 x 10(-8)) and 19q13.11 (rs10500264, P = 4.26 x 10(-10)). Our scan also detected associations at 23 of 32 loci previously implicated in adult-onset Crohn's disease and at 8 of 17 loci implicated in adult-onset ulcerative colitis, highlighting the close pathogenetic relationship between early- and adult-onset IBD.

Document type Article de périodique (Journal article) – Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
Access type Accès libre
Publication date 2009
Language Anglais
Journal information "Nature Genetics" - Vol. 41, no. 12, p. 1335-1340 (2009)
Peer reviewed yes
Publisher Nature Publishing Group ((United States) New York)
issn 1061-4036
e-issn 1546-1718
Publication status Publié
Affiliations UCL - (SLuc) Service d'hépato-gastro-entérologie
UCL - MD/MINT - Département de médecine interne
MESH Subject Age of Onset ; Chromosome Mapping ; Colitis, Ulcerative - genetics ; Genetic Variation ; Genome, Human ; Genome-Wide Association Study ; Humans ; Inflammatory Bowel Diseases - epidemiology, genetics
Links
  1. Kugathasan S., Nat. Genet., 40, 1211 (2008)
  2. Van Limbergen J., Annu. Rev. Genomics Hum. Genet., 10, 89 (2009)
  3. Cho J.H., Nat. Rev. Immunol., 8, 458 (2008)
  4. Fisher S.A., Nat. Genet., 40, 710 (2008)
  5. Barrett J.C., Nat. Genet., 40, 955 (2008)
  6. Franke A., Nat. Genet., 40, 1319 (2008)
  7. Silverberg M.S., Nat. Genet., 41, 216 (2009)
  8. Vernier-Massouille G., Gastroenterology, 135, 1106 (2008)
  9. Van Limbergen J., Gastroenterology, 135, 1114 (2008)
  10. Rioux J.D., Nat. Genet., 39, 596 (2007)
  11. Nature, 447, 661 (2007)
  12. Libioulle C., PLoS Genet., 3, e58 (2007)
  13. Barrett J.C., Nat. Genet., 41, 703 (2009)
  14. Dixon A.L., Nat. Genet., 39, 1202 (2007)
  15. Li X., J. Biol. Chem., 281, 23748 (2006)
  16. Steinman L., Nat. Med., 13, 139 (2007)
  17. Bettelli E., Nat. Immunol., 8, 345 (2007)
  18. Hakonarson H., Nature, 448, 591 (2007)
  19. Pritchard J.K., Genetics, 155, 945 (2000)
  20. Luca D., Am. J. Hum. Genet., 82, 453 (2008)
  21. Patterson N., PLoS Genet., 2, e190 (2006)
  22. Duerr R.H., Science, 314, 1461 (2006)
  23. Parkes M., Nat. Genet., 39, 830 (2007)
  24. Purcell S., Am. J. Hum. Genet., 81, 559 (2007)
Bibliographic reference Imielinski, Marcin ; Baldassano, Robert N ; Griffiths, Anne ; Russell, Richard K ; Annese, Vito ; et. al. Common variants at five new loci associated with early-onset inflammatory bowel disease.. In: Nature Genetics, Vol. 41, no. 12, p. 1335-1340 (2009)
Permanent URL http://hdl.handle.net/2078.1/109361