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Pharmacological inhibition of the MAPK/ERK pathway increases sensitivity to 2-chloro-2'-deoxyadenosine (CdA) in the B-cell leukemia cell line EHEB.
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Document type | Article de périodique (Journal article) – Article de recherche |
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Access type | Accès restreint |
Publication date | 2007 |
Journal information | "Biochemical Pharmacology" - Vol. 73, no. 3, p. 351-358 (2007) |
Peer reviewed | yes |
Publisher | Elsevier Inc. (Philadelphia) |
issn | 0006-2952 |
e-issn | 1873-2968 |
Publication status | Publié |
Affiliations |
UCL
- MD/BICL - Département de biochimie et de biologie cellulaire UCL - MD/MINT - Département de médecine interne UCL - (SLuc) Service d'hématologie |
MESH Subject | Antineoplastic Agents - pharmacology ; Cell Line, Tumor ; Cladribine - pharmacology ; Drug Interactions ; Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors - metabolism ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy - pathology ; MAP Kinase Signaling System - drug effects ; Phosphorylation ; Protein Kinase Inhibitors - pharmacology |
Keywords | MAPK/ERK pathway ; 2-Chloro-2'-deoxyadenosine ; EHEB ; MEK inhibitors ; Caspase-3 ; Chronic lymphocytic leukemia |
Links |
Bibliographic reference | Smal, Caroline ; Lisart, Stéphanie ; Maerevoet, Marie ; Ferrant, Augustin ; Bontemps, Françoise ; et. al. Pharmacological inhibition of the MAPK/ERK pathway increases sensitivity to 2-chloro-2'-deoxyadenosine (CdA) in the B-cell leukemia cell line EHEB.. In: Biochemical Pharmacology, Vol. 73, no. 3, p. 351-358 (2007) |
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Permanent URL | http://hdl.handle.net/2078.1/10790 |