Noël, Timothy
[]
Robeyns, Koen
[UCL]
Van Meervelt, Luc
[]
Van der Eycken, Erik
[]
Van der Eycken, Johan
[]
Various chiral bidentate oxazoline-alcohol ligands were obtained in a straightforward one-step synthesis via a cyclic imidate ester rearrangement. These chiral ligands were tested and compared in asymmetric diethylzinc additions to aldehydes resulting in selectivities of up to 87% ee. An interesting chirality switch was observed when a CPh2-tether instead of a CH2 was present, offering the opportunity for dual stereocontrol. © 2009 Elsevier Ltd. All rights reserved.
Bibliographic reference |
Noël, Timothy ; Robeyns, Koen ; Van Meervelt, Luc ; Van der Eycken, Erik ; Van der Eycken, Johan. Efficient one-step synthesis of chiral bidentate oxazoline-alcohol ligands via a cyclic imidate ester rearrangement. In: Tetrahedron Asymmetry, Vol. 20, no. 17, p. 1962-1968 (2009) |
Permanent URL |
http://hdl.handle.net/2078/107422 |