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Enhancement of IgG production elicited in mice by treatment with anti-CD8 antibody.

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Coutelier, Jean-Paul [UCL]

Injection of an anti-CD8 monoclonal antibody into mice was followed by an increase in the production of immunoglobulins of the IgG1, IgG2a and IgG2b, but neither the IgG3 nor the IgM isotypes. A maximal effect was observed 6 days after administration of 100 micrograms antibody. However, no modification of spleen cell proliferation was elicited by the anti-CD8 treatment. Virally induced IgG2a and IgG2b secretion remained unchanged in mice infected with lactate dehydrogenase-elevating virus that received a concomitant injection of anti-CD8 antibody, whereas an enhancement of IgG1 was observed. Simultaneous treatment with an anti-CD4 antibody abrogated the immunoglobulin secretion triggered by anti-CD8. These results suggest that immunoglobulin production in unmanipulated mice is controlled by CD8+ lymphocytes.

Document type Article de périodique (Journal article) – In Vitro, Journal Article, Research Support, Non-U.S. Gov't
Publication date 1991
Journal information "European journal of immunology" - Vol. 21, no. 10, p. 2617-20 (1991)
Peer reviewed yes
issn 0014-2980
Publication status Publié
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject Animals ; Antibody Formation ; Antigens, CD8 - immunology ; CD4-Positive T-Lymphocytes - immunology ; Female ; Immunoglobulin G - biosynthesis ; Immunoglobulin Isotypes - biosynthesis ; Isoantibodies - immunology ; Lymphocyte Depletion ; Mice ; Mice, Inbred CBA ; T-Lymphocytes, Helper-Inducer - immunology ; T-Lymphocytes, Regulatory - immunology
Links
  1. Cobbold, Nature, 312, 548 (1984)
  2. Coulie, Eur. J. Immunol., 15, 638 (1985)
  3. Bryson, Cell. Immunol., 129, 138 (1990)
  4. Tarleton, J. Immunol., 144, 717 (1990)
  5. Moskophidis, Proc. Natl. Acad. Sci. USA, 86, 3291 (1989)
  6. Kantwerk, Clin. Exp. Immunol., 70, 585 (1987)
  7. Nagarkatti, Cell. Immunol., 112, 64 (1988)
  8. Coutelier, J. Virol., 64, 5383 (1990)
  9. Leclerc, J. Immunol., 145, 1343 (1990)
  10. Newell, J. Virol., 63, 769 (1989)
  11. Kadima-Nzuji, Am. J. Pathol., 137, 907 (1990)
  12. Leist, J. Exp. Med., 167, 1749 (1988)
  13. Benaroch, J. Exp. Med., 168, 891 (1988)
  14. Coutelier, Eur. J. Immunol., 15, 250 (1985)
  15. Ledbetter, Immunol. Rev., 47, 63 (1979)
  16. Ho, J. Immunol., 128, 1221 (1982)
  17. Dialynas, Immunol. Rev., 74, 29 (1983)
  18. Ceredig, Nature, 314, 98 (1985)
  19. Sarmiento, J. Immunol., 125, 2665 (1980)
  20. Coutelier, J. Exp. Med., 168, 2373 (1988)
  21. Finkelman, Annu. Rev. Immunol., 8, 303 (1990)
  22. Ovary, Immunol. Rev., 41, 26 (1978)
  23. Löwy, J. Immunol., 128, 768 (1982)
  24. Löwy, Cell. Immunol., 91, 467 (1985)
  25. Löwy, Cell. Immunol., 94, 609 (1985)
  26. Gisler, J. Exp. Med., 142, 507 (1975)
  27. Teillaud, Immunol. Lett., 16, 139 (1987)
  28. Varin, Eur. J. Immunol., 19, 2263 (1989)
  29. Néauport-Sautès, Nature, 277, 656 (1979)
  30. Teillaud, Cell. Immunol., 63, 349 (1981)
  31. Daëron, Eur. J. Immunol., 15, 662 (1985)
  32. Löwy, Proc. Natl. Acad. Sci. USA, 80, 2323 (1983)
  33. Daëron, Eur. J. Immunol., 15, 668 (1985)
Bibliographic reference Coutelier, Jean-Paul. Enhancement of IgG production elicited in mice by treatment with anti-CD8 antibody.. In: European journal of immunology, Vol. 21, no. 10, p. 2617-20 (1991)
Permanent URL http://hdl.handle.net/2078.1/10630