User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

The MTHFR CT polymorphism confers a high risk for stroke in both homozygous and heterozygous T allele carriers with Type 2 diabetes.

  1. de Bree A, Am J Clin Nutr, 77, 687 (2003)
  2. Kluijtmans L. A. J., Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults, 10.1182/blood.v101.7.2483
  3. Manson J. E., A prospective study of maturity-onset diabetes mellitus and risk of coronary heart disease and stroke in women, 10.1001/archinte.151.6.1141
  4. Stamler J, Diabetes Care, 16, 434 (1993)
  5. Kothari V., Stevens R. J., Adler A. I., Stratton I. M., Manley S. E., Neil H. A., Holman R. R., UKPDS 60: Risk of Stroke in Type 2 Diabetes Estimated by the UK Prospective Diabetes Study Risk Engine, 10.1161/01.str.0000020091.07144.c7
  6. Boushey C. J., A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes, 10.1001/jama.274.13.1049
  7. Munshi Medha N., Stone Angie, Fink Louis, Fonseca Vivian, Hyperhomocysteinemia following a methionine load in patients with non-insulin-dependent diabetes mellitus and macrovascular disease, 10.1016/s0026-0495(96)90211-5
  8. Nygård Ottar, Nordrehaug Jan Erik, Refsum Helga, Ueland Per Magne, Farstad Mikael, Vollset Stein Emil, Plasma Homocysteine Levels and Mortality in Patients with Coronary Artery Disease, 10.1056/nejm199707243370403
  9. Hoogeveen E. K., Kostense P. J., Beks P. J., Mackaay A. J. C., Jakobs C., Bouter L. M., Heine R. J., Stehouwer C. D. A., Hyperhomocysteinemia Is Associated With an Increased Risk of Cardiovascular Disease, Especially in Non Insulin-Dependent Diabetes Mellitus : A Population-Based Study, 10.1161/01.atv.18.1.133
  10. Okada E, Diabetes Care, 22, 484 (1999)
  11. Hoogeveen E. K., Kostense P. J., Jakobs C., Dekker J. M., Nijpels G., Heine R. J., Bouter L. M., Stehouwer C. D. A., Hyperhomocysteinemia Increases Risk of Death, Especially in Type 2 Diabetes : 5-Year Follow-Up of the Hoorn Study, 10.1161/01.cir.101.13.1506
  12. Becker A., Kostense P. J., Bos G., Heine R. J., Dekker J. M., Nijpels G., Bouter L. M., Stehouwer C. D. A., Hyperhomocysteinaemia is associated with coronary events in type 2 diabetes, 10.1046/j.1365-2796.2003.01113.x
  13. Buysschaert M, Mises Au Point Cliniques D'endocrinologie, Nutrition et Metabolisme., 169 (2003)
  14. Buysschaert M, Journees de Diabetologie Hotel-Dieu 2003., 229 (2003)
  15. Lawrence de Koning A.B., Werstuck Geoff H., Zhou Ji, Austin Richard C., Hyperhomocysteinemia and its role in the development of atherosclerosis, 10.1016/s0009-9120(03)00062-6
  16. Soinio Minna, Marniemi Jukka, Laakso Markku, Lehto Seppo, Rönnemaa Tapani, Elevated Plasma Homocysteine Level Is an Independent Predictor of Coronary Heart Disease Events in Patients with Type 2 Diabetes Mellitus, 10.7326/0003-4819-140-2-200401200-00009
  17. Welch George N., Loscalzo Joseph, Homocysteine and Atherothrombosis, 10.1056/nejm199804093381507
  18. Stanger O., Herrmann W., Pietrzik K., Fowler B., Geisel J., Dierkes J., Weger M., DACH-LIGA Homocystein (German, Austrian and Swiss Homocysteine Society): Consensus Paper on the Rational Clinical Use of Homocysteine, Folic Acid and B-Vitamins in Cardiovascular and Thrombotic Diseases: Guidelines and Recommendations, 10.1515/cclm.2003.214
  19. Geisel Jürgen, Hübner Ulrich, Bodis Marion, Schorr Heike, Knapp Jean-Pierre, Obeid Rima, Herrmann Wolfgang, The Role of Genetic Factors in the Development of Hyperhomocysteinemia, 10.1515/cclm.2003.219
  20. Buysschaert M, Diabetes Metab, 30, 349 (2004)
  21. Casas Juan P, Bautista Leonelo E, Smeeth Liam, Sharma Pankaj, Hingorani Aroon D, Homocysteine and stroke: evidence on a causal link from mendelian randomisation, 10.1016/s0140-6736(05)17742-3
  22. Frosst P., Blom H.J., Milos R., Goyette P., Sheppard C.A., Matthews R.G., Boers G.J.H., den Heijer M., Kluijtmans L.A.J., van den Heuve L.P., Rozen R., A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase, 10.1038/ng0595-111
  23. Girelli D, Blood, 91, 4158 (1998)
  24. Fodinger M, J Nephrol, 13, 1 (1999)
  25. Fodinger M, Kidney Int, 52, 517 (1997)
  26. Lim Paik-Seong, Hung Wan-Ru, Wei Yau-Huei, Polymorphism in Methylenetetrahydrofolate Reductase Gene: Its Impact on Plasma Homocysteine Levels and Carotid Atherosclerosis in ESRD Patients Receiving Hemodialysis, 10.1159/000045922
  27. Buysschaert M, Diabetes Care, 23, 1816 (2000)
  28. Kang S., Hyperhomocyst(e)inemia as a Risk Factor for Occlusive Vascular Disease, 10.1146/annurev.nutr.12.1.279
  29. , Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, 10.2337/diacare.20.7.1183
  30. 28The Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults . Third report. Available from:
  31. , UK prospective diabetes study (UKPDS) : VIII. Study design, progress and performance, 10.1007/bf00400195
  32. Buysschaert M, Diabetes Metab, 27, 655 (2001)
  33. Hermans MP, Diabetes, 48, 1779 (1999)
  34. 32OMIM'. Online Mendelian inheritance in man. Available from:
  35. Szolnoki Z, Evaluation of the modifying effects of unfavourable genotypes on classical clinical risk factors for ischaemic stroke, 10.1136/jnnp.74.12.1615
  36. Kim Robert J, Becker Richard C, Association between factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: a meta-analysis of published studies, 10.1016/s0002-8703(03)00519-2
  37. Kissela BM, Diabetes Care, 28, 355 (2005)
  38. Fonseca V., Hyperhomocysteinemia and the Endocrine System: Implications for Atherosclerosis and Thrombosis, 10.1210/er.20.5.738
  39. Chango A, Br J Nutr, 83, 593 (2000)
  40. Meleady R, Am J Clin Nutr, 77, 63 (2003)
  41. Homocysteine Studies Collaboration, Homocysteine and Risk of Ischemic Heart Disease and Stroke : A Meta-analysis, 10.1001/jama.288.16.2015
  42. Klerk Mariska, Verhoef Petra, Clarke Robert, Blom Henk J., Kok Frans J., Schouten Evert G., and the MTHFR Studies Collaboration Group, MTHFR 677C→T Polymorphism and Risk of Coronary Heart Disease : A Meta-analysis, 10.1001/jama.288.16.2023
  43. Geisel Jürgen, Hennen Benno, Hübner Ulrich, Knapp Jean-Pierre, Herrmann Wolfgang, The Impact of Hyperhomocysteinemia as a Cardiovascular Risk Factor in the Prediction of Coronary Heart Disease, 10.1515/cclm.2003.232
  44. Stanger Olaf, Weger Martin, Interactions of Homocysteine, Nitric Oxide, Folate and Radicals in the Progressively Damaged Endothelium, 10.1515/cclm.2003.222
  45. Aso Y., Okumura K., Yoshida N., Tayama K., Kanda T., Kobayashi I., Takemura Y., Inukai T., Plasma interleukin-6 is associated with coagulation in poorly controlled patients with Type 2 diabetes, 10.1046/j.1464-5491.2003.01058.x
  46. Selhub J, Am J Clin Nutr, 71, 614S (2000)
  47. Mutus B., Rabini R. A., Staffolani R., Ricciotti R., Fumelli P., Moretti N., Martarelli D., Mazzanti L., Homocysteine-induced inhibition of nitric oxide production in platelets: a study on healthy and diabetic subjects, 10.1007/s001250100581
  48. Uçar Fahri, Sönmez Mehmet, Ovalı Ercüment, Özmenoǧlu Mehmet, Kartı S. Sami, Yılmaz Mustafa, Pakdemir Alper, MTHFR C677T polymorphism and its relation to ischemic stroke in the Black Sea Turkish population : MTHFR Polymorphism and Ischemic Stroke, 10.1002/ajh.20050
  49. Li Z., Sun L., Zhang H., Liao Y., Wang D., Zhao B., Zhu Z., Zhao J., Ma A., Han Y., Wang Y., Shi Y., Ye J., Hui R., Elevated Plasma Homocysteine Was Associated With Hemorrhagic and Ischemic Stroke, but Methylenetetrahydrofolate Reductase Gene C677T Polymorphism Was a Risk Factor for Thrombotic Stroke: A Multicenter Case-Control Study in China, 10.1161/01.str.0000086753.00555.0d
  50. Kohara K., Fujisawa M., Ando F., Tabara Y., Niino N., Miki T., Shimokata H., MTHFR Gene Polymorphism as a Risk Factor for Silent Brain Infarcts and White Matter Lesions in the Japanese General Population: The NILS-LSA Study, 10.1161/01.str.0000069163.02611.b0
  51. Rodríguez‐Esparragón Francisco, Hernández‐Perera Octavio, Rodríguez‐Pérez José C., Anabitarte Aránzazu, Díaz‐Cremades Juan M., Losada Antonio, Fiuza Dolores, Hernández Enrique, Yunis Carla, Ferrario Carlos M., The Effect of Methylenetetrahydrofolate Reductase C677T Common Variant on Hypertensive Risk Is Not Solely Explained by Increased Plasma Homocysteine Values, 10.1081/ceh-120020391
  52. Stehouwer Coen D. A., Guldener Coen van, Does Homocysteine Cause Hypertension?, 10.1515/cclm.2003.216
  53. Kelly P. J., Rosand J., Kistler J. P., Shih V. E., Silveira S., Plomaritoglou A., Furie K. L., Homocysteine, MTHFR 677C->T polymorphism, and risk of ischemic stroke: Results of a meta-analysis, 10.1212/wnl.59.4.529
Bibliographic reference Hermans, Michel ; Gala, Jean-Luc ; Buysschaert, Martin. The MTHFR CT polymorphism confers a high risk for stroke in both homozygous and heterozygous T allele carriers with Type 2 diabetes.. In: Diabetic medicine : a journal of the British Diabetic Association, Vol. 23, no. 5, p. 529-36 (2006)
Permanent URL