User menu

Detection of tumour hypoxia: comparison between EF5 adducts and [18F]EF3 uptake on an individual mouse tumour basis.

Bibliographic reference Mahy, Pierre ; De Bast, Marc ; Gillart, Jacques ; Labar, Daniel ; Grégoire, Vincent. Detection of tumour hypoxia: comparison between EF5 adducts and [18F]EF3 uptake on an individual mouse tumour basis.. In: European journal of nuclear medicine and molecular imaging, Vol. 33, no. 5, p. 553-6 (2006)
Permanent URL http://hdl.handle.net/2078.1/10508
  1. Hockel M, Vaupel P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 2001;93:266–276
  2. Mahy P., De Bast M., Leveque P.H., Gillart J., Labar D., Marchand J., Gregoire V., Preclinical validation of the hypoxia tracer 2-(2-nitroimidazol-1-yl)-N-(3,3,3-[18F]trifluoropropyl)acetamide, [18F]EF3, 10.1007/s00259-004-1573-2
  3. Koch CJ. Measurement of absolute oxygen levels in cells and tissues using oxygen sensors and 2-nitroimidazole EF5. Methods Enzymol 2002;352:3–31
  4. Mahy P, De Bast M, Gallez B, Gueulette J, Koch CJ, Scalliet P, Grégoire V. In vivo colocalisation of 2-nitroimidazole EF5 fluorescence intensity and electron paramagnetic resonance oximetry in mouse tumors. Radiother Oncol 2003;67:53–61
  5. Josse O, Labar D, Georges B, Grégoire V, Marchand-Brynaert J. Synthesis of [18F]-labeled EF3 [2-(2-nitroimidazol-1-yl)-N-(3,3,3-trifluoropropyl)-acetamide], a marker for PET detection of hypoxia. Bioorg Med Chem 2001;9:665–675
  6. Milas L, Hunter N, Mason K, Withers HR. Immunological resistance to pulmonary metastases in C3Hf/Bu mice bearing syngeneic fibrosarcoma of different sizes. Cancer Res 1974;34:61–71
  7. Evans SM, Joiner B, Jenkins WT, Laughlin KM, Lord EM, Koch CJ, Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide], 10.1038/bjc.1995.427
  8. Mahy P, Reychler H, Gueulette J, Scalliet P, Grégoire V. Immunofluorescence analysis of hypoxia in squamous cell carcinoma and fibrosarcoma murine tumors using a pentafluorinated nitroimidazole compound (EF5). J Cranio-Maxillofac Surg 1998;26:111
  9. Rasey JS, Grunbaum Z, Magee S, Nelson NJ, Olive PL, Durand RE, Krohn KA. Characterization of radiolabeled fluoromisonidazole as a probe for hypoxic cells. Radiat Res 1987;111:292–304