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The immunological monitoring of alloreactive responses in liver transplant recipients: a review.

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Reding, Raymond [UCL] Gras, Jérémie Truong, Dinh Quang Wieers, Grégoire [UCL] Latinne, Dominique [UCL]

The aim of this work is to review the current knowledge in the field of immunological monitoring of allogenic responsiveness in clinical liver transplantation. When compared to other solid-organ transplants, liver allografts are considered as immunologically privileged, and, accordingly, constitute a favorable setting to develop experimental as well as clinical strategies for minimization of immunosuppression and even induction of operational tolerance. The validation of simple, reliable, noninvasive assays exploring antidonor alloreactivity will constitute a crucial step toward implementing such approaches in the clinic. In contrast to research in rodents claiming the development of donor-specific tolerance in case of graft survivals of over 100 days without immunosuppression, it is impractical to confirm tolerance induction in this way in humans. Promising candidate assays include the detection of post-transplant immune deviation, of circulating precursors of dendritic cells subtypes, and of regulatory T cells. A conceptual framework for the development of tolerance assays in clinical liver transplantation is also proposed.

Document type Article de périodique (Journal article) – Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Review
Access type Accès restreint
Publication date 2006
Journal information "Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society" - Vol. 12, no. 3, p. 373-83 (2006)
Peer reviewed yes
issn 1527-6465
Publication status Publié
Affiliations UCL - MD/CHIR - Département de chirurgie
UCL - (SLuc) Centre de pathologie anorectale de l'enfant
UCL - (SLuc) Service de chirurgie et transplantation abdominale
UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Centre de thérapie tissulaire et cellulaire
UCL - (SLuc) Service d'hématologie
MESH Subject Biological Markers - blood ; Female ; Graft Rejection ; Graft Survival ; Humans ; Immune Tolerance - physiology ; Liver Transplantation - immunology - methods ; Male ; Monitoring, Physiologic - methods ; Prognosis ; Transplantation Immunology - physiology ; Transplantation, Homologous - immunology
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Bibliographic reference Reding, Raymond ; Gras, Jérémie ; Truong, Dinh Quang ; Wieers, Grégoire ; Latinne, Dominique. The immunological monitoring of alloreactive responses in liver transplant recipients: a review.. In: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, Vol. 12, no. 3, p. 373-83 (2006)
Permanent URL http://hdl.handle.net/2078.1/10494