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Cardiac and neurological assessment of normothermia/warm blood cardioplegia vs hypothermia/cold crystalloid cardioplegia in pediatric cardiac surgery : insight from a prospective randomized trial.

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Poncelet, Alain [UCL] van Steenberghe, Mathieu [UCL] Moniotte, Stéphane [UCL] Detaille, Thierry [UCL] Beauloye, Christophe [UCL] Bertrand, Luc [UCL] Nassogne, Marie-Cécile [UCL] Rubay, Jean [UCL]

Although normothermia and warm blood cardioplegia are widely used in adults, cold crystalloids and hypothermia remain routinely used in pediatric cardiac surgery. The superiority of either technique in both brain and myocardial protection remains controversial. We designed a prospective randomized study to compare both approaches in terms of early myocardial protection and late neurodevelopmental status.

Document type Article de périodique (Journal article) – Article de recherche – Clinical Trial, Phase I, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 2011
Language Anglais
Journal information "European Journal of Cardio-Thoracic Surgery" - Vol. 40, no. 6, p. 1384-1390 (2011)
Peer reviewed yes
Publisher Elsevier BV ((Netherlands) Amsterdam)
issn 1010-7940
e-issn 1873-734X
Publication status Publié
Affiliations UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire
UCL - (SLuc) Service de chirurgie cardiovasculaire et thoracique
UCL - (SLuc) Service de cardiologie
UCL - SSS/IONS/NEUR - Clinical Neuroscience
UCL - (SLuc) Service de neurologie pédiatrique
UCL - (SLuc) Service de cardiologie pédiatrique
UCL - (SLuc) Service de soins intensifs
UCL - SSS/IREC/PEDI - Pôle de Pédiatrie
MESH Subject Psychometrics ; Postoperative Complications ; Neuropsychological Tests ; Myocardial Reperfusion Injury - prevention & control ; Isotonic Solutions ; Intelligence ; Infant ; Hypothermia, Induced - adverse effects - methods ; Humans ; Heart Defects, Congenital - surgery ; Heart Arrest, Induced - adverse effects - methods ; Epidemiologic Methods ; Developmental Disabilities - etiology ; Child, Preschool ; Cardiopulmonary Bypass - methods ; Cardioplegic Solutions ; Biological Markers - metabolism ; Adenosine Triphosphate - metabolism
Keywords congenital heart disease ; myocardial metabolism ; myocardial protection/cardioplegia ; neurocognitive deficits
Links
Bibliographic reference Poncelet, Alain ; van Steenberghe, Mathieu ; Moniotte, Stéphane ; Detaille, Thierry ; Beauloye, Christophe ; et. al. Cardiac and neurological assessment of normothermia/warm blood cardioplegia vs hypothermia/cold crystalloid cardioplegia in pediatric cardiac surgery : insight from a prospective randomized trial.. In: European Journal of Cardio-Thoracic Surgery, Vol. 40, no. 6, p. 1384-1390 (2011)
Permanent URL http://hdl.handle.net/2078.1/104449