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Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase 3.

Bibliographic reference Feyt, Christine ; Courtoy, Pierre J. ; Kienlen-Campard, Pascal ; Leroy, Karelle ; N'Kuli, Francisca ; et. al. Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase 3.. In: The Journal of biological chemistry, Vol. 280, no. 39, p. 33220-7 (2005)
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  1. Braak H., Braak E., Neuropathological stageing of Alzheimer-related changes, 10.1007/bf00308809
  2. Masters C. L., Simms G., Weinman N. A., Multhaup G., McDonald B. L., Beyreuther K., Amyloid plaque core protein in Alzheimer disease and Down syndrome., 10.1073/pnas.82.12.4245
  3. Kang Jie, Lemaire Hans-Georg, Unterbeck Axel, Salbaum J. Michael, Masters Colin L., Grzeschik Karl-Heinz, Multhaup Gerd, Beyreuther Konrad, Müller-Hill Benno, The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor, 10.1038/325733a0
  4. Acta Neurol. Belg., 95, 197 (1995)
  5. Rev. Neurosci., 6, 287 (1995)
  6. Vassar R., Beta-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE, 10.1126/science.286.5440.735
  7. De Strooper Bart, Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex, 10.1016/s0896-6273(03)00205-8
  8. Edbauer Dieter, Winkler Edith, Regula Joerg T., Pesold Brigitte, Steiner Harald, Haass Christian, Reconstitution of γ-secretase activity, 10.1038/ncb960
  9. Lammich S., Kojro E., Postina R., Gilbert S., Pfeiffer R., Jasionowski M., Haass C., Fahrenholz F., Constitutive and regulated  -secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease, 10.1073/pnas.96.7.3922
  10. J. Neurochem., 67, 699 (1996)
  11. Iijima Ko-ichi, Ando Kanae, Takeda Shizu, Satoh Yasushi, Seki Tatsunori, Itohara Shigeyoshi, Greengard Paul, Kirino Yutaka, Nairn Angus C., Suzuki Toshiharu, Neuron-Specific Phosphorylation of Alzheimer's β-Amyloid Precursor Protein by Cyclin-Dependent Kinase 5, 10.1046/j.1471-4159.2000.0751085.x
  12. Standen Claire L., Brownlees Janet, Grierson Andrew J., Kesavapany Sashi, Lau Kwok-Fai, McLoughlin Declan M., Miller Christopher C. J., Phosphorylation of thr668 in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3) : Phosphorylation of APP by SAPK1b, 10.1046/j.1471-4159.2001.00102.x
  13. J. Submicrosc. Cytol., 17, 89 (1985)
  14. van Noort Mascha, Meeldijk Jan, van der Zee Ruurd, Destree Olivier, Clevers Hans, Wnt Signaling Controls the Phosphorylation Status of β-Catenin, 10.1074/jbc.m111635200
  15. Stambolic Vuk, Ruel Laurent, Woodgett James R., Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells, 10.1016/s0960-9822(02)70790-2
  16. Muñoz-Montaño Juan Ramón, Moreno Francisco J., Avila Jesús, Dı́az-Nido Javier, Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons, 10.1016/s0014-5793(97)00688-1
  17. Hong Ming, Chen Daniel C. R., Klein Peter S., Lee Virginia M.-Y., Lithium Reduces Tau Phosphorylation by Inhibition of Glycogen Synthase Kinase-3, 10.1074/jbc.272.40.25326
  18. Lovestone Simon, Davis Danny R, Webster Marie-Therese, Kaech Stefanie, Brion Jean-Pierre, Matus Andrew, Anderton Brian H, Lithium reduces tau phosphorylation: effects in living cells and in neurons at therapeutic concentrations, 10.1016/s0006-3223(98)00183-8
  19. Sun X., Sato S., Murayama O., Murayama M., Park J.-M., Yamaguchi H., Takashima A., Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100, 10.1016/s0304-3940(01)02583-6
  20. Phiel Christopher J., Wilson Christina A., Lee Virginia M.-Y., Klein Peter S., GSK-3α regulates production of Alzheimer's disease amyloid-β peptides, 10.1038/nature01640
  21. Su Yuan, Ryder John, Li Baolin, Wu Xin, Fox Niles, Solenberg Pat, Brune Kellie, Paul Steven, Zhou Yan, Liu Feng, Ni Binhui, Lithium, a Common Drug for Bipolar Disorder Treatment, Regulates Amyloid-β Precursor Protein Processing, 10.1021/bi035627j
  22. Ryder John, Su Yuan, Liu Feng, Li Baolin, Zhou Yan, Ni Binhui, Divergent roles of GSK3 and CDK5 in APP processing, 10.1016/j.bbrc.2003.11.014
  23. Delacourte A., Defossez A., Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments, 10.1016/0022-510x(86)90167-x
  24. Dovey H. F., John V., Anderson J. P., Chen L. Z., De Saint Andrieu P., Fang L. Y., Freedman S. B., Folmer B., Goldbach E., Holsztynska E. J., Hu K. L., Johnson-Wood K. L., Kennedy S. L., Kholodenko D., Knops J. E., Latimer L. H., Lee M., Liao Z., Lieberburg I. M., Motter R. N., Mutter L. C., Nietz J., Quinn K. P., Sacchi K. L., Seubert P. A., Shopp G. M., Thorsett E. D., Tung J. S., Wu J., Yang S., Yin C. T., Schenk D. B., May P. C., Altstiel L. D., Bender M. H., Boggs L. N., Britton T. C., Clemens J. C., Czilli D. L., Dieckman-McGinty D. K., Droste J. J., Fuson K. S., Gitter B. D., Hyslop P. A., Johnstone E. M., Li W-Y., Little S. P., Mabry T. E., Miller F. D., Ni B., Nissen J. S., Porter W. J., Potts B. D., Reel J. K., Stephenson D., Su Y., Shipley L. A., Whitesitt C. A., Yin T., Audia J. E., Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain : γ-secretase inhibitors reduce Aβ levels in PDAPP mouse brain, 10.1046/j.1471-4159.2001.00012.x
  25. Brion J P, Hanger D P, Bruce M T, Couck A M, Flament-Durand J, Anderton B H, Tau in Alzheimer neurofibrillary tangles.N- andC-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site, 10.1042/bj2730127
  26. Essalmani Rachid, Macq Anne-Françoise, Mercken Luc, Octave Jean-Noël, Missense Mutations Associated with Familial Alzheimer's Disease in Sweden Lead to the Production of the Amyloid Peptide without Internalization of Its Precursor, 10.1006/bbrc.1996.0017
  27. Macq Anne-Françoise, Czech Christian, Essalmani Rachid, Brion Jean-Pierre, Maron Anne, Mercken Luc, Pradier Laurent, Octave Jean-Noël, The Long Term Adenoviral Expression of the Human Amyloid Precursor Protein Shows Different Secretase Activities in Rat Cortical Neurons and Astrocytes, 10.1074/jbc.273.44.28931
  28. Brewer G. J., Serum-free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus, 10.1002/jnr.490420510
  29. Lemarchand P., Jaffe H. A., Danel C., Cid M. C., Kleinman H. K., Stratford-Perricaudet L. D., Perricaudet M., Pavirani A., Lecocq J. P., Crystal R. G., Adenovirus-mediated transfer of a recombinant human alpha 1-antitrypsin cDNA to human endothelial cells., 10.1073/pnas.89.14.6482
  30. Stratford-Perricaudet L D, Makeh I, Perricaudet M, Briand P, Widespread long-term gene transfer to mouse skeletal muscles and heart., 10.1172/jci115902
  31. Coghlan Matthew P, Culbert Ainsley A, Cross Darren AE, Corcoran Stacey L, Yates John W, Pearce Nigel J, Rausch Oliver L, Murphy Gregory J, Carter Paul S, Roxbee Cox Lynne, Mills David, Brown Murray J, Haigh David, Ward Robert W, Smith David G, Murray Kenneth J, Reith Alastair D, Holder Julie C, Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription, 10.1016/s1074-5521(00)00025-9
  32. Kienlen-Campard Pascal, Octave Jean-Noël, Correlation between β-amyloid peptide production and human APP-induced neuronal death, 10.1016/s0196-9781(02)00055-4
  33. Ermolieff Jacques, Loy Jeffrey A., Koelsch Gerald, Tang Jordan, Proteolytic Activation of Recombinant Pro-memapsin 2 (Pro-β-secretase) Studied with New Fluorogenic Substrates†, 10.1021/bi001494f
  34. J. Biol. Chem., 261, 6084 (1986)
  35. Abbenante G., Kovacs D.M., Leung D.L., Craik D.J., Tanzi R.E., Fairlie D.P., Inhibitors of β-Amyloid Formation Based on the β-Secretase Cleavage Site, 10.1006/bbrc.2000.2098
  36. Kumaraswamy S., Bergstedt T., Shi X., Rininsland F., Kushon S., Xia W., Ley K., Achyuthan K., McBranch D., Whitten D., Fluorescent-conjugated polymer superquenching facilitates highly sensitive detection of proteases, 10.1073/pnas.0402367101
  37. Leighton F., THE LARGE-SCALE SEPARATION OF PEROXISOMES, MITOCHONDRIA, AND LYSOSOMES FROM THE LIVERS OF RATS INJECTED WITH TRITON WR-1339: Improved Isolation Procedures, Automated Analysis, Biochemical and Morphological Properties of Fractions, 10.1083/jcb.37.2.482
  38. Ida Nobuo, Hartmann Tobias, Pantel Johannes, Schröder Johannes, Zerfass Rainer, Förstl Hans, Sandbrink Rupert, Masters Colin L., Beyreuther Konrad, Analysis of Heterogeneous βA4 Peptides in Human Cerebrospinal Fluid and Blood by a Newly Developed Sensitive Western Blot Assay, 10.1074/jbc.271.37.22908
  39. Kienlen-Campard Pascal, Miolet Sarah, Tasiaux Bernadette, Octave Jean-Noël, Intracellular Amyloid-β1–42, but Not Extracellular Soluble Amyloid-β Peptides, Induces Neuronal Apoptosis, 10.1074/jbc.m200887200
  40. Cupers Philippe, Veithen Alex, Hoekstra Dick, Baudhuin Pierre, Courtoy Pierre J., Three Unrelated Perturbations Similarly Uncouple Fluid, Bulk-Membrane, and Receptor Endosomal Flow in Rat Fetal Fibroblasts, 10.1006/bbrc.1997.7033
  41. Saraste J., Antibodies to rat pancreas Golgi subfractions: identification of a 58- kD cis-Golgi protein, 10.1083/jcb.105.5.2021
  42. Citron Martin, Teplow David B, Selkoe Dennis J, Generation of amyloid β protein from its precursor is sequence specific, 10.1016/0896-6273(95)90323-2
  43. Brion J P, Hanger D P, Couck A M, Anderton B H, A68 proteins in Alzheimer's disease are composed of several tau isoforms in a phosphorylated state which affects their electrophoretic mobilities, 10.1042/bj2790831
  44. Reynolds C. Hugh, Betts Joanna C., Blackstock Walter P., Nebreda Angel R., Anderton Brian H., Phosphorylation Sites on Tau Identified by Nanoelectrospray Mass Spectrometry : Differences In Vitro Between the Mitogen-Activated Protein Kinases ERK2, c-Jun N-Terminal Kinase and P38, and Glycogen Synthase Kinase-3β, 10.1046/j.1471-4159.2000.0741587.x
  45. Sperbera Brian R., Leight Susan, Goedert Michel, Lee V.M.-Y., Glycogen synthase kinase-3β phosphorylates tau protein at multiple sites in intact cells, 10.1016/0304-3940(95)11902-9
  46. Hanger Diane P., Hughes Kenneth, Woodgett James R., Brion Jean-Pierre, Anderton Brian H., Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase, 10.1016/0304-3940(92)90774-2
  47. Lovestone Simon, Reynolds C.Hugh, Latimer Donna, Davis Daniel R., Anderton Brian H., Gallo Jean-Marc, Hanger Diane, Mulot Sandrine, Marquardt Betina, Stabel Silvia, Woodgett James R., Miller Christopher C.J., Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells, 10.1016/s0960-9822(00)00246-3