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Mercapturic acids revisited as biomarkers of exposure to reactive chemicals in occupational toxicology: a minireview.

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Haufroid, Vincent [UCL] Lison, Dominique [UCL]

A minireview is presented concerning the use of mercapturic acids as biological exposure index for electrophilic chemicals. Besides pure analytical aspects, this minireview considers possible issues in relation to (a) the added value of mercapturic acids as compared to other well validated biomarkers of exposure and (b) the high inter-individual variability in mercapturic acids excretion. Recent field and/or experimental studies confirm the usefulness of mercapturic acids as biological exposure index for electrophilic chemicals and suggest the interest of a toxicogenetic approach for a better interpretation of the results of biological monitoring.

Document type Article de périodique (Journal article) – Journal Article, Review
Access type Accès restreint
Publication date 2005
Journal information "International archives of occupational and environmental health" - Vol. 78, no. 5, p. 343-54 (2005)
Peer reviewed yes
issn 0340-0131
Publication status Publié
Affiliation UCL - MD/ESP - Ecole de santé publique
MESH Subject Acetylcysteine - diagnostic use - urine ; Belgium ; Biological Markers ; Glutathione ; Humans ; Occupational Exposure ; Toxicogenetics
Keywords Biomarkers ; Mercapturic acids ; Glutathione ; Toxicogenetics
Links
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Bibliographic reference Haufroid, Vincent ; Lison, Dominique. Mercapturic acids revisited as biomarkers of exposure to reactive chemicals in occupational toxicology: a minireview.. In: International archives of occupational and environmental health, Vol. 78, no. 5, p. 343-54 (2005)
Permanent URL http://hdl.handle.net/2078.1/10184