Banmeyer, Ingrid
Marchand, Cécile
Clippe, André
[UCL]
Knoops, Bernard
[UCL]
Peroxiredoxin 5 is a thioredoxin peroxidase ubiquitously expressed in mammalian tissues. Peroxiredoxin 5 can be addressed intracellularly to mitochondria, peroxisomes, the cytosol and the nucleus. Here, we show that mitochondrial human peroxiredoxin 5 protects mitochondrial DNA (mtDNA) from oxidative attacks. In an acellular assay, recombinant peroxiredoxin 5 was shown to protect plasmid DNA from damages induced by metal-catalyzed generation of reactive oxygen species. In Chinese hamster ovary cells, overexpression of mitochondrial peroxiredoxin 5 significantly decreased mtDNA damages caused by exogenously added hydrogen peroxide. Altogether our results suggest that mitochondrial peroxiredoxin 5 may play an important role in mitochondrial genome stability.
- Yakes F. M., Van Houten B., Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress, 10.1073/pnas.94.2.514
- Ljungman Mats, Hanawalt Philip C., Efficient protection against oxidative DNA damage in chromatin, 10.1002/mc.2940050406
- Dizdaroglu Mirai, Rao Govind, Halliwell Barry, Gajewski Ewa, Damage to the DNA bases in mammalian chromatin by hydrogen peroxide in the presence of ferric and cupric ions, 10.1016/0003-9861(91)90366-q
- Graziewicz M. A., The mitochondrial DNA polymerase as a target of oxidative damage, 10.1093/nar/gkf392
- Bohr Vilhelm A, Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells1,2 1Guest Editor: Miral Dizdaroglu 2This article is part of a series of reviews on “Oxidative DNA Damage and Repair.” The full list of papers may be found on the homepage of the journal., 10.1016/s0891-5849(02)00787-6
- Wallace D. C., Mitochondrial Diseases in Man and Mouse, 10.1126/science.283.5407.1482
- Wood Zachary A, Schröder Ewald, Robin Harris J, Poole Leslie B, Structure, mechanism and regulation of peroxiredoxins, 10.1016/s0968-0004(02)00003-8
- Chae, J. Biol. Chem., 269, 27670 (1994)
- Nathan Carl, Bryk Ruslana, Griffin Patrick, 10.1038/35025109
- Dubuisson Marlène, Vander Stricht Delphine, Clippe André, Etienne Florence, Nauser Thomas, Kissner Reinhard, Koppenol Willem H, Rees Jean-François, Knoops Bernard, Human peroxiredoxin 5 is a peroxynitrite reductase, 10.1016/j.febslet.2004.06.080
- Knoops Bernard, Clippe André, Bogard Cédric, Arsalane Karim, Wattiez Ruddy, Hermans Cédric, Duconseille Elee, Falmagne Paul, Bernard Alfred, Cloning and Characterization of AOEB166, a Novel Mammalian Antioxidant Enzyme of the Peroxiredoxin Family, 10.1074/jbc.274.43.30451
- Watabe, J. Biochem. (Tokyo), 115, 648 (1994)
- Banmeyer Ingrid, Marchand Cécile, Verhaeghe Catherine, Vucic Bénédicte, Rees Jean-François, Knoops Bernard, Overexpression of human peroxiredoxin 5 in subcellular compartments of chinese hamster ovary cells: effects on cytotoxicity and DNA damage caused by peroxides, 10.1016/j.freeradbiomed.2003.10.019
- Wong Chi-Ming, Siu Kam-Leung, Jin Dong-Yan, Peroxiredoxin-null Yeast Cells Are Hypersensitive to Oxidative Stress and Are Genomically Unstable, 10.1074/jbc.m402095200
- Huang M.-E., Rio A.-G., Nicolas A., Kolodner R. D., A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations, 10.1073/pnas.2035018100
- Seo Min Seok, Kang Sang Won, Kim Kanghwa, Baines Ivan C., Lee Tae Hoon, Rhee Sue Goo, Identification of a New Type of Mammalian Peroxiredoxin That Forms an Intramolecular Disulfide as a Reaction Intermediate, 10.1074/jbc.m001943200
- Oberley Terry D, Verwiebe Eric, Zhong Weixiong, Kang Sang Won, Rhee Sue Goo, Localization of the thioredoxin system in normal rat kidney, 10.1016/s0891-5849(00)00486-x
- Leyens Gregory, Knoops Bernard, Donnay Isabelle, Expression of peroxiredoxins in bovine oocytes and embryos produced in vitro, 10.1002/mrd.20145
- Kwon S.J., Kim K., Kim I.H., Yoon I.K., Park J.W., Strand Breaks in DNA Induced by a Thiol/Fe(III)/O2 Mixed-Function Oxidase System and Its Protection by a Yeast Antioxidant Protein, 10.1006/bbrc.1993.1481
- Declercq Jean-Paul, Evrard Christine, Clippe André, Stricht Delphine Vander, Bernard Alfred, Knoops Bernard, Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 Å resolution, 10.1006/jmbi.2001.4853
- Plaisant Frank, Clippe André, Vander Stricht Delphine, Knoops Bernard, Gressens Pierre, Recombinant peroxiredoxin 5 protects against excitotoxic brain lesions in newborn mice, 10.1016/s0891-5849(02)01440-5
- Wang Min-Xia, Wei Aiqun, Yuan Jun, Clippe André, Bernard Alfred, Knoops Bernard, Murrell George A.C., Antioxidant Enzyme Peroxiredoxin 5 Is Upregulated in Degenerative Human Tendon, 10.1006/bbrc.2001.4991
- Santos, Methods Mol. Biol., 197, 159 (2002)
- Kim, J. Biol. Chem., 263, 4704 (1988)
- COOKE M. S., Oxidative DNA damage: mechanisms, mutation, and disease, 10.1096/fj.02-0752rev
- Ritter Wolfgang, Plank Christian, Lausier James, Rudolph Carsten, Zink Daniela, Reinhardt Dietrich, Rosenecker Joseph, A novel transfecting peptide comprising a tetrameric nuclear localization sequence, 10.1007/s00109-003-0483-2
- Escriou Virginie, Carrière Marie, Scherman Daniel, Wils Pierre, NLS bioconjugates for targeting therapeutic genes to the nucleus, 10.1016/s0169-409x(02)00184-9
- Kim, J. Biol. Chem., 260, 15394 (1985)
- Shigenaga M. K., Gimeno C. J., Ames B. N., Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage., 10.1073/pnas.86.24.9697
- Santos Janine Hertzog, Hunakova L'uba, Chen Yiming, Bortner Carl, Van Houten Bennett, Cell Sorting Experiments Link Persistent Mitochondrial DNA Damage with Loss of Mitochondrial Membrane Potential and Apoptotic Cell Death, 10.1074/jbc.m208752200
- Sikorsky Jan A., Primerano Donald A., Fenger Terry W., Denvir James, Effect of DNA damage on PCR amplification efficiency with the relative threshold cycle method, 10.1016/j.bbrc.2004.08.168
- Arosio Paolo, Levi Sonia, Ferritin, iron homeostasis, and oxidative damage1,2 1Guest Editor: Mario Comporti 2This article is part of a series of reviews on “Iron and Cellular Redox Status.” The full list of papers may be found on the homepage of the journal., 10.1016/s0891-5849(02)00842-0
- Salazar, Mutat. Res., 385, 139 (1997)
- Yuan Jun, Murrell George A.C, Trickett Annette, Landtmeters Marie, Knoops Bernard, Wang Min-Xia, Overexpression of antioxidant enzyme peroxiredoxin 5 protects human tendon cells against apoptosis and loss of cellular function during oxidative stress, 10.1016/j.bbamcr.2004.04.006
- Byrnes Robert W., Inhibition of Hydroperoxide-Induced DNA Single-Strand Breakage by 1,10-Phenanthroline in HL-60 Cells: Implications for Iron Speciation, 10.1006/abbi.1996.0318
- Bryszewska M., Piasecka A., Zavodnik L.B., Distel L., Schüssler H., Oxidative damage of Chinese hamster fibroblasts induced by t-butyl hydroperoxide and by X-rays, 10.1016/s0304-4165(03)00096-5
- Mazhul V, THE EFFECT OF OXIDATIVE STRESS INDUCED BY t-BUTYL HYDROPEROXIDE ON THE STRUCTURAL DYNAMICS OF MEMBRANE PROTEINS OF CHINESE HAMSTER FIBROBLASTS, 10.1006/cbir.1999.0366
- Mambo E., Gao X., Cohen Y., Guo Z., Talalay P., Sidransky D., Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations, 10.1073/pnas.0437910100
- Suliman Hagir B, Carraway Martha Sue, Velsor Leonard W, Day Brian J, Ghio Andrew J, Piantadosi Claude A, Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure, 10.1016/s0891-5849(01)00797-3
- Leyens Gregory, Donnay Isabelle, Knoops Bernard, Cloning of bovine peroxiredoxins—gene expression in bovine tissues and amino acid sequence comparison with rat, mouse and primate peroxiredoxins, 10.1016/s1096-4959(03)00290-2
Bibliographic reference |
Banmeyer, Ingrid ; Marchand, Cécile ; Clippe, André ; Knoops, Bernard. Human mitochondrial peroxiredoxin 5 protects from mitochondrial DNA damages induced by hydrogen peroxide.. In: FEBS letters, Vol. 579, no. 11, p. 2327-33 (2005) |
Permanent URL |
http://hdl.handle.net/2078.1/10166 |