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Risk of hepatocellular carcinoma in liver mitochondrial respiratory chain disorders.

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Scheers, Isabelle [UCL] Bachy, Vincent [UCL] Stéphenne, Xavier [UCL] Sokal, Etienne [UCL]

Mitochondrial respiratory chain disorders (MRCD) are a large group of disorders that can affect any organ besides muscles or the central nervous system. We report two children who presented with neonatal cholestasis and progressive cirrhosis, who subsequently developed hepatocellular carcinoma (HCC). This suggests a particular risk of degeneration in these patients and the importance of a regular screening for secondary liver cancer. Suggestion of HCC should lead to early liver transplantation, which was successful without tumor recurrence in the two patients.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2005
Journal information "The Journal of Pediatrics" - Vol. 146, no. 3, p. 414-417 (2005)
Peer reviewed yes
Publisher Mosby, Inc. (Philadelphia)
issn 0022-3476
e-issn 1097-6833
Publication status Publié
Affiliations UCL - MD/GYPE - Département de gynécologie, d'obstétrique et de pédiatrie
UCL - (MGD) Service d'oto-rhino-laryngologie
UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique
UCL - (SLuc) Centre de pathologie anorectale de l'enfant
UCL - (SLuc) Centre de thérapie tissulaire et cellulaire
MESH Subject Carcinoma, Hepatocellular - etiology ; Child ; Humans ; Liver ; Liver Neoplasms - etiology ; Liver Transplantation ; Male ; Mitochondria, Liver - enzymology ; Mitochondrial Myopathies - complications ; Risk Factors ; alpha-Fetoproteins - metabolism
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Bibliographic reference Scheers, Isabelle ; Bachy, Vincent ; Stéphenne, Xavier ; Sokal, Etienne. Risk of hepatocellular carcinoma in liver mitochondrial respiratory chain disorders.. In: The Journal of Pediatrics, Vol. 146, no. 3, p. 414-417 (2005)
Permanent URL http://hdl.handle.net/2078.1/10127