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Affichage: 1 - 25 sur 83 résultats.

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    • Article de périodique
    Anomalous reactivity of benzopinacolone towards 4-phenylthiosemicarbazide, a nucleophile endowed with alpha-effect
    Kassehin, Comlan Urbain[UCL] Adjibode, Steeve A Bautista, Oscar[UCL] Gbaguidi, Fernand A Quetin-Leclercq, Joëlle[UCL] McCurdy, Christopher R Frédérick, Raphaël[UCL] Poupaert, Jacques[UCL] (2019) Journal of Medicinal and Chemical Sciences — Vol. 2, no.1, p. 17-20 (2019)
    • Article de périodique
    Convenient one-pot formation of highly functionalized 5-bromo-2-aminothiazoles, potential endocannabinoid hydrolase MAGL inhibitors
    Prevost, Julien R.C.[UCL] Kozlova, Arina[UCL] Es Saadi, Bouazza[UCL] Yildiz, Esra[UCL] Modaffari, Sara Lambert, Didier M.[UCL] Pochet, Lionel Wouters, Johan Dolušić, Eduard Frédérick, Raphaël[UCL] (2018) Tetrahedron Letters — Vol. 59, no.49, p. 4315-4319 (2018)
    • Article de périodique
    Current state on tryptophan 2,3-dioxygenase inhibitors: a patent review
    Kozlova, Arina[UCL] Frédérick, Raphaël[UCL] (2019) Expert Opinion on Therapeutic Patents — Vol. 29, no. 1, p. 11-23 (2019)
    • Communication
    Identification and development of LDH inhibitors to treat cancer
    Sonveaux, Pierre[UCL] Frédérick, Raphaël[UCL] (2021) Seminar Series of the European Institute of Chemistry and Biology (IECB) —
    • Article de périodique
    Olaparib is a mitochondrial Complex I inhibitor that kills temozolomide-resistant human glioblastoma cells
    Zampieri, Luca[UCL] Sboarina, Martina[UCL] Cacace, Andrea[UCL] Grasso, Debora[UCL] Thabault, Léopold[UCL] Hamelin, Loïc[UCL] Vazeille, Thibaut[UCL] Dumon, Elodie Rossignol, Rodrigue Frédérick, Raphaël[UCL] Sonveaux, Etienne[UCL] Lefranc, Florence Sonveaux, Pierre[UCL] (2021) International Journal of Molecular Sciences — Vol. 22, no.11938, p. 17 (2021)
    • Brevet
    Lactate dehydrogenase inhibitor polypeptides for use in treatment of cancer
    Frédérick, Raphaël[UCL] Thabault, Léopold[UCL] Brisson, Lucie Copetti, Tamara Sonveaux, Pierre[UCL] (2019)
    • Article de périodique
    Interrogating the lactate dehydrogenase tetramerization site using (stapled) peptides.
    Thabault, Léopold[UCL] Brisson, Lucie[UCL] Brustenga, Chiara[UCL] Martinez Gache, Santiago A Prévost, Julien[UCL] Kozlova, Arina[UCL] Spillier, Quentin[UCL] Liberelle, Maxime[UCL] Benyahia, Zohra[UCL] Messens, Joris Copetti, Tamara[UCL] Sonveaux, Pierre[UCL] Frédérick, Raphaël[UCL] (2020) Journal of medicinal chemistry — Vol. 63, no.9, p. 4628-4643 (2020)
    • Brevet
    Polypeptide inhibitors of lactate dehydrogenase activity for use in cancer therapy
    Sonveaux, Pierre[UCL] Thabault, Léopold[UCL] Liberelle, Maxime[UCL] Frédérick, Raphaël[UCL] (2021)
    • Article de périodique
    Pharmacomodulations of the benzoyl-thiosemicarbazide scaffold reveal antimicrobial agents targeting D-alanyl-D-alanine ligase in bacterio
    Ameryckx, Alice[UCL] Pochet, Lionel Wang, Gang[UCL] Yildiz, Esra[UCL] Es Saadi, Bouazza[UCL] Wouters, Johan Van Bambeke, Françoise[UCL] Frédérick, Raphaël[UCL] (2020) European Journal of Medicinal Chemistry — Vol. 200, no.1, p. 112444 (2020)
    • Article de périodique
    Unravelling the Allosteric Targeting of PHGDH at the ACT-Binding Domain with a Photoactivatable Diazirine Probe and Mass Spectrometry Experiments
    Spillier, Quentin[UCL] Ravez, Séverine Dochain Simon[UCL] Vertommen, Didier[UCL] Thabault, Léopold[UCL] Feron, Olivier[UCL] Frédérick, Raphaël[UCL] (2021) Molecules — Vol. 26, no. 2, p. 477 (2021)
    • Article de périodique
    The putative Escherichia coli dehydrogenase YjhC metabolises two dehydrated forms of N-acetylneuraminate produced by some sialidases
    Kentache, Takfarinas[UCL] Thabault, Léopold[UCL] Peracchi, Alessio Frédérick, Raphaël[UCL] Bommer, Guido[UCL] Van Schaftingen, Emile[UCL] (2020) Bioscience Reports — Vol. 40, no.6, p. 1-15 (2020)
    • Article de périodique
    1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio
    Ameryckx, Alice[UCL] Thabault, Léopold[UCL] Pochet, Lionel Leimanis, Serge Poupaert, Jacques[UCL] Wouters, Johan Joris, Bernard Van Bambeke, Françoise[UCL] Frédérick, Raphaël[UCL] (2018) European Journal of Medicinal Chemistry — Vol. 159, p. 324-338 (2018)
    • Article de périodique
    The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate
    Kentache, Takfarinas[UCL] Thabault, Léopold[UCL] Deumer, Gladys[UCL] Haufroid, Vincent[UCL] Frédérick, Raphaël[UCL] Linster, Carole Peracchi, Alessio[UCL] Veiga da Cunha, Maria[UCL] Bommer, Guido[UCL] Van Schaftingen, Emile[UCL] (2021) The Journal of biological chemistry — Vol. 296, p. 100699 [1-12] (2021)
    • Article de périodique
    Targeting protein self-association in drug design.
    Thabault, Léopold[UCL] Liberelle, Maxime[UCL] Frédérick, Raphaël[UCL] (2021) Drug Discovery Today — Vol. 26, no. 5, p. 1148-1163 (2021)
    • Article de périodique
    Structure–Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH)
    Spillier, Quentin[UCL] Ravez, Severine Unterlass, Judith Corbet, Cyril[UCL] Degavre, Charline[UCL] Feron, Olivier[UCL] Frédérick, Raphaël[UCL] (2020) Pharmaceuticals — Vol. 13, no.2, p. 20 (2020)
    • Article de périodique
    29ièmes Journées Franco-Belges de Pharmacochimie: Meeting Report
    The Members of the Organizing Committee Frédérick, Raphaël[UCL] Pochet, Lionel[FUNDP] De Tullio, Pascal Dufrasne, François E.[UCL] (2015) Pharmaceuticals — Vol. 8, no.4, p. 758-777 (2015)
    • Article de périodique
    α-Ketothioamide derivatives: a promising tool to interrogate the phosphoglycerate dehydrogenase (PHGDH).
    Ravez, Séverine Corbet, Cyril[UCL] Spillier, Quentin Dutu, Alice Robin, Anita D Mullarky, Edouard Cantley, Lewis Clayton Feron, Olivier[UCL] Frédérick, Raphaël (2017) Journal of Medicinal Chemistry — (2017)
    • Article de périodique
    31ièmes Journées Franco-Belges de Pharmacochimie: Meeting Report.
    Frédérick, Raphaël[UCL] Pochet, Lionel De Tullio, Pascal Dufrasne, François (2017) Pharmaceuticals — Vol. 10, p. 94 [1-12] (2017)
    • Brevet
    Serine biosynthetic pathway inhibitors
    Frédérick, Raphaël[UCL] Ravez, Séverine[UCL] Spillier, Quentin[UCL] Corbet, Cyril[UCL] Feron, Olivier[UCL]
    • Article de périodique
    Challenges and Opportunities in the Development of Serine Synthetic Pathway Inhibitors for Cancer Therapy.
    Ravez, Séverine[UCL] Spillier, Quentin[UCL] Marteau, Romain[UCL] Feron, Olivier[UCL] Frédérick, Raphaël[UCL] (2017) Journal of Medicinal Chemistry — Vol. 60, no. 4, p. 1227-1237 (2017)
    • Article de périodique
    Targeting cancer cells in acidosis with conjugates between the carnitine palmitoyltransferase 1 inhibitor etomoxir and pH (low) insertion peptides
    Deskeuvre, Marine Lan, Junjie Dierge, Emeline Messens, Joris Riant, Olivier[UCL] Corbet, Cyril[UCL] Feron, Olivier[UCL] Frédérick, Raphaël[UCL] (2022) International Journal of Pharmaceutics — Vol. 624, no.1, p. 122041 (2022)
    • Article de périodique
    Structural study of bioisosteric derivatives of 5-(1<i>H</i>-indol-3-yl)-benzotriazole and their ability to form chalcogen bonds
    Mirgaux, Manon Scaillet, Tanguy Kozlova, Arina[UCL] Tumanov, Nikolay Frédérick, Raphaël[UCL] Bodart, Laurie Wouters, Johan (2022) Acta Crystallographica Section E Crystallographic Communications — Vol. 78, no. 4, p. 418-424 (2022)
    • Article de périodique
    Impact of PEGylation on an antibody-loaded nanoparticle-based drug delivery system for the treatment of inflammatory bowel disease.
    Shrestha, Neha Xu, Yining[UCL] Prévost, Julien R C McCartney, Fiona Brayden, David Frédérick, Raphaël[UCL] Beloqui Garcia, Ana[UCL] Préat, Véronique[UCL] (2022) Acta biomaterialia — Vol. 140, p. 561-572 (2022)
    • Article de périodique
    Tandem Heck/Tsuji-Trost Reaction for Uncaging of Alloc-Protected Amines with Palladium Complexes in Living Cells
    Tan, Yonghua[UCL] Lefevre, Marine[UCL] Pierrard, François[UCL] Soetens, Mathieu[UCL] Shoueiry, Maria[UCL] Yildiz, Esra[UCL] Ibanez, Sébastien[UCL] Ozkan, Kubra[UCL] Feron, Olivier[UCL] Frédérick, Raphaël[UCL] Riant, Olivier[UCL] (2023) Journal of Organometallic Chemistry — Vol. 996, no.-, p. 122743 (2023)
    • Article de périodique
    Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes
    Solvay, Marie[UCL] Holfelder, Pauline Klaessens, Simon[UCL] Pilotte, Luc[UCL] Stroobant, Vincent[UCL] Lamy, Juliette Naulaerts, Stefan[UCL] Spillier, Quentin[UCL] Frédérick, Raphaël[UCL] De Plaen, Etienne[UCL] Sers, Christine Opitz, Christiane A Van den Eynde, Benoit[UCL] Zhu, Jingjing[UCL] (2023) Journal for ImmunoTherapy of Cancer — Vol. 11, no. 6, p. e006728 (2023)

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