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Calculation of the renal perfusion and glomerular filtration rate from the renal impulse response obtained with MRI.

Onglets principaux

Hermoye, Laurent [UCL] Annet, Laurence [UCL] Lemmerling, Ph. Peeters, Frank [UCL] Jamar, François [UCL] Gianello, Pierre [UCL] Van Beers, Bernard [UCL]

The aim of this study was to assess the importance of deconvolution for the calculation of renal perfusion and glomerular filtration rate (GFR) on the basis of concentration-time curves as measured with perfusion MRI. Six rabbits were scanned dynamically after injection of a gadolinium chelate. Concentration-time curves were generated by manually drawing regions of interest in the aorta and the renal cortex. To remove the dependency on the arterial input function, a regularized structured total least-squares deconvolution algorithm was used to calculate the renal impulse response. This curve was fitted by the sum of two gamma variate functions, corresponding to the passage of the contrast agent in the glomeruli and the proximal convoluted tubules. Tracer kinetics models were applied to these two functions to obtain the renal perfusion and GFR. For comparison, these two parameters were also calculated on the basis of the renal concentration-time curve before deconvolution. The renal perfusion values correlated well (r = 0.9, P = 0.014) with the values calculated by a validated upslope method. The GFR values correlated well (r = 0.9, P = 0.014) with the values obtained from the clearance of (51)Cr-EDTA. A comparison of the values obtained with and without deconvolution demonstrated the necessity of deconvolution.

Type de document Article de périodique (Journal article) – Article de recherche – Journal Article, Research Support, Non-U.S. Gov't
Type d'accès Accès restreint
Année de publication 2004
Langue Anglais
Information sur le périodique "Magnetic Resonance in Medicine" - Vol. 51, no. 5, p. 1017-1025 (2004)
Peer reviewed oui
Editeur JohnWiley & Sons, Inc. (Hoboken)
issn 0740-3194
e-issn 1522-2594
Statut de la publication Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - MD/CHIR - Département de chirurgie
UCL - MD/RAIM - Département de radiologie et d'imagerie médicale
UCL - (SLuc) Service de radiologie
UCL - (SLuc) Service de médecine nucléaire
UCL - (SLuc) Service de chirurgie et transplantation abdominale
MESH Subject Algorithms ; Animals ; Computer Simulation ; Gadolinium - diagnostic use ; Glomerular Filtration Rate - physiology ; Kidney - physiology ; Magnetic Resonance Imaging - methods ; Male ; Models, Theoretical ; Rabbits ; Renal Circulation - physiology
Mots-clés Magnetic resonance imaging ; MRI ; Kidney ; Perfusion ; Glomerular filtration ; Deconvolution ; Constrat media
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Référence bibliographique Hermoye, Laurent ; Annet, Laurence ; Lemmerling, Ph. ; Peeters, Frank ; Jamar, François ; et. al. Calculation of the renal perfusion and glomerular filtration rate from the renal impulse response obtained with MRI.. In: Magnetic Resonance in Medicine, Vol. 51, no. 5, p. 1017-1025 (2004)
Permalien http://hdl.handle.net/2078.1/9832