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Strychnopentamine, a potential anticancer agent

Onglets principaux

Quetin-Leclercq, Joëlle [UCL] Bouzahzah, B. Pons, A. Greimers, Roland Angenot, Luc Barbason, Hervé

We analysed the effects of strychnopentamine, an alkaloid isolated from Strychnos usambarensis, on an Ehrlich ascites tumor growing in the mouse after inoculation. Four subcutaneous injections of 1.5 mg strychnopentamine (1 per day) induce a significant decrease of the number of tumor cells and a significant increase of the survival of the treated mice. Observed side effects are partial haemolysis and some liver damage.

Type de document Article de périodique (Journal article) – Article de recherche – Journal Article, Research Support, Non-U.S. Gov't
Type d'accès Accès restreint
Année de publication 1993
Langue Anglais
Information sur le périodique "Planta Medica : natural products and medicinal plant research" - Vol. 59, no. 1, p. 59-62 (1993)
Peer reviewed oui
Editeur GeorgThieme Verlag ((Germany) Stuttgart)
issn 0032-0943
e-issn 1439-0221
Statut de la publication Publié
Affiliations UCL - MD/FARM - Ecole de pharmacie
MESH Subject Alkaloids - therapeutic use ; Animals ; Antineoplastic Agents, Phytogenic - chemistry, therapeutic use ; Carcinoma, Ehrlich Tumor - chemistry, drug therapy ; Drug Screening Assays, Antitumor ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Structure
Liens
Référence bibliographique Quetin-Leclercq, Joëlle ; Bouzahzah, B. ; Pons, A. ; Greimers, Roland ; Angenot, Luc ; et. al. Strychnopentamine, a potential anticancer agent. In: Planta Medica : natural products and medicinal plant research, Vol. 59, no. 1, p. 59-62 (1993)
Permalien http://hdl.handle.net/2078/87253