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Chemometric Optimization in Drug Analysis By Hplc - a Critical-evaluation of the Quality Criteria Used in the Analysis of Drug Purity

Onglets principaux

Vanbel, PF. Gilliard, JA. Tilquin, Bernard [UCL]

Optimization procedures require adequate response criteria to assess the quality of each chromatogram obtained during the process. The objective of this paper is to evaluate the possibility of using different resolution functions, in the chromatographic separation of a drug and its impurities (particularly the impurity just eluted after the drug). This study shows the limits of some resolution expressions. The interest of the simple DELTAt criterion, the difference between retention times, is presented in this paper.

Type de document Communication à un colloque (Conference Paper) – Présentation orale avec comité de sélection
Type d'accès Accès restreint
Année de publication 1993
Langue Anglais
Conférence "19TH INTERNATIONAL SYMP ON CHROMATOGRAPHY", AIX EN PROVENCE(France) (Sep 13-18, 1992)
Information sur le périodique "Chromatographia" - Vol. 36, p. 120-124 (1993)
Peer reviewed oui
issn 0009-5893
e-issn 1612-1112
Editeur Friedr Vieweg Sohn Verlag Gmbh (Wiesbaden 1)
Affiliations UCL - MD/FARM - Ecole de pharmacie
Mots-clés Column Liquid Chromatography ; Method Development ; Chemometrics ; Response Criteria ; Analysis Of Drug Purity
Liens
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Référence bibliographique Vanbel, PF. ; Gilliard, JA. ; Tilquin, Bernard. Chemometric Optimization in Drug Analysis By Hplc - a Critical-evaluation of the Quality Criteria Used in the Analysis of Drug Purity.19TH INTERNATIONAL SYMP ON CHROMATOGRAPHY (AIX EN PROVENCE(France), Sep 13-18, 1992). In: Chromatographia, Vol. 36, p. 120-124 (1993)
Permalien http://hdl.handle.net/2078.1/63486