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Use of Positron Emission Tomography (pet) in Stereotaxic Conditions for Brain Biopsy

Onglets principaux

Pirotte, B. Goldman, S. Bidaut, LM. Luxen, A. Stanus, E. Brucher, Jean-Marie [UCL] Levivier, M.

In order to take advantage of the metabolic information provided by positron emission tomography (PET) in cases of brain tumour, we have developed a technique to integrate PET images routinely in the planning of stereotactic brain biopsy. We used stereotactic PET with [F-18]-labelled fluorodeoxyglucose (PET-FDG) in 38 patients undergoing brain biopsy. To evaluate the contribution of PET-FDG in guiding brain biopsy, we analyzed the diagnosis provided by the 78 stereotactic trajectories obtained in these patients. We found that stereotactic PET-FDG seemed to provide more information in cases of anaplastic astrocytomas and glioblastomas than in low-grade gliomas. Our results also show that biopsy trajectories performed in areas where increased FDG uptake is found within the lesion boundaries always provide interpretable specimens; this was not the case for trajectories guided by CT only. Therefore, the routine integration PET-FDG in the planning of stereotactic brain biopsy may lead to a reduction in sampling. Recently, we also tested consecutive stereotactic PET with [C-11]-labelled methionine (PET-Met) and PET-FDG. This technique allowed us to compare accurately the tumoural glucose metabolism and protein synthesis. Our results suggest that stereotactic PET may increase the diagnostic yield of brain biopsy and may improve the understanding of PET in neuro-oncology.

Type de document Communication à un colloque (Conference Paper) – Présentation orale avec comité de sélection
Type d'accès Accès restreint
Année de publication 1995
Langue Anglais
Conférence "Joint Meeting of the Belgian, Dutch, and German Neurosurgical Societies on Modern Trends and Innovative Techniques in Clinical Neurosurgery in Adults", MAASTRICHT(Netherlands) (Feb 11-13, 1993)
Information sur le périodique "Acta Neurochirurgica : the European journal of neurosurgery" - Vol. 134, no. 1-2, p. 79-82 (1995)
Peer reviewed oui
issn 0001-6268
e-issn 0942-0940
Editeur Springer-verlag Wien (Vienna)
Affiliations UCL - Autre
Mots-clés Stereotaxic Biopsy ; Positron Emission Tomography ; Brain Tumor
Liens
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Référence bibliographique Pirotte, B. ; Goldman, S. ; Bidaut, LM. ; Luxen, A. ; Stanus, E. ; et. al. Use of Positron Emission Tomography (pet) in Stereotaxic Conditions for Brain Biopsy.Joint Meeting of the Belgian, Dutch, and German Neurosurgical Societies on Modern Trends and Innovative Techniques in Clinical Neurosurgery in Adults (MAASTRICHT(Netherlands), Feb 11-13, 1993). In: Acta Neurochirurgica : the European journal of neurosurgery, Vol. 134, no. 1-2, p. 79-82 (1995)
Permalien http://hdl.handle.net/2078.1/63119