Boël, P.
Wildmann, C.
Sensi, ML.
Brasseur, R.
Renauld, Jean-Christophe
[UCL]
Coulie, Pierre G.
[UCL]
Boon, Thierry
[UCL]
van der Bruggen, Pierre
[UCL]
Several tumor antigens are recognized by autologous cytolytic T lymphocytes (CTL) on human melanoma MZ2-MEL. Some of them are encoded by genes MAGE-1 and MAGE-3, which are not expressed in normal tissues except in testis. Here, we report the identification of a new gene that codes for another of these antigens. This gene, named SAGE, codes for a putative protein of 43 aa and seems to belong to a family of several genes. The antigen recognized by the autologous CTL consists of BAGE-encoded peptide AARAVFLAL bound to an HLA-Cw*1601 molecule. Gene BAGE is expressed in 22% of melanomas, 30% of infiltrating bladder carcinomas, 10% of mammary carcinomas, 8% of head and neck squamous cell carcinomas, and 6% of non-small cell lung carcinomas. Like the MAGE genes, it is silent in normal tissues with the exception of testis. Because of its tumor-specific expression, the BAGE-encoded antigen may prove useful for cancer immunotherapy.
Référence bibliographique |
Boël, P. ; Wildmann, C. ; Sensi, ML. ; Brasseur, R. ; Renauld, Jean-Christophe ; et. al. Bage - a New Gene Encoding An Antigen Recognized On Human Melanomas By Cytolytic T-lymphocytes. In: Immunity, Vol. 2, no. 2, p. 167-175 (1995) |
Permalien |
http://hdl.handle.net/2078.1/48238 |