Chepkirui, Clara
[Department of Microbial Drugs, Helmholtz Centre for Infection Research; and German Centre for Infection Research (DZIF), Partner Site Hannover/Braunschweig,Germany]
Yuyama, Kamila T.
[Department of Chemical Microbiology, Helmholtz Centre for Infection Research,Braunschweig, Germany]
Wanga, Lucy A.
[Department of Biochemistry, Faculty of Sciences, Egerton University, Njoro, Kenya]
Decock, Cony
[UCL]
Matasyoh, Josphat C.
[Department of Chemistry, Faculty of Sciences, Egerton University, Njoro, Kenya]
Abraham, Wolf-Rainer
[Department of Chemical Microbiology, Helmholtz Centre for Infection Research,Braunschweig, Germany]
Stadler, Marc
[ Centre for Infection Research; and German Centre for Infection Research (DZIF), Partner Site Hannover/Braunschweig,Germany]
The need for effective compounds to combat antimicrobial resistance and biofilms which play important roles in human infections continues to pose a major health challenge. Seven previously undescribed acyclic diterpenes linked to isocitric acid by an ether linkage, microporenic acids A-G (1-7), were isolated from the cultures of a hitherto undescribed species of the genus Microporus (Polyporales, Basidiomycota) originating from Kenya's Kakamega forest. Microporenic acids D and E (4 and 5) showed antimicrobial activity against a panel of Gram positive bacteria and a yeast, Candida tenuis. Moreover, microporenic acids A and B (1 and 2) demonstrated dose-dependent inhibition of biofilm formation by Staphylococcus aureus. Compound 1 further showed significant activity against Candida albicans and Staphylococcus aureus preformed biofilms.
Chepkirui, Clara ; Yuyama, Kamila T. ; Wanga, Lucy A. ; Decock, Cony ; Matasyoh, Josphat C. ; et. al. Microporenic Acids A–G, Biofilm Inhibitors, and Antimicrobial Agents from the Basidiomycete Microporus Species. In: Journal of Natural Products, Vol. 2018, p. 1-7 (2018)