Menu utilisateur

Accès à distance ? S'identifier sur le proxy UCLouvain

Does acamprosate improve reduction of drinking as well as aiding abstinence?

Onglets principaux

Chick, J. Landron, Frédéric Lehert, Philippe [FUCAM]

(eng) Data on patients' alcohol consumption from 15 placebo-controlled treatment studies (n = 3309) were examined to test whether, at a given time point, patients who have taken one or more drinks since the last assessment (‘relapsers', n = 1010) take alcohol on fewer days, report lower average number of drinks per day, and consume less alcohol in total with acamprosate compared to placebo. These studies had varying duration (90 days, 180 days and 360 days). Among relapsers, acamprosate was significantly associated with less quantity (Q) and frequency (F) of drinking compared to placebo in each of the four follow-up periods (p < 0.001). The differences were most marked for the product Q x F (overall weekly consumption). For each period, there were fewer who were drinking an average of five or more drinks per day in the acamprosate compared to the placebo groups. Acamprosate helps reduce the severity of relapse in patients undergoing abstinence-orientated treatment.

Type de document Article de périodique (Journal article)
Type d'accès Accès restreint
Année de publication 2003
Langue Anglais
Information sur le périodique "Journal of PsychoPharmacology" - Vol. 17 (2003)
Peer reviewed oui
issn 0269-8811
e-issn 1461-7285
Statut de la publication Publié
Affiliations Louvain School of Management
Liens
  1. Qatari Mona, Bouchenafa Ouahiba, Littleton John, Mechanism of Action of Acamprosate. Part II. Ethanol Dependence Modifies Effects of Acamprosate on NMDA Receptor Binding in Membranes from Rat Cerebral Cortex, 10.1111/j.1530-0277.1998.tb03872.x
  2. Anton R F, Am J Psychiatry, 156, 1758 (1999)
  3. Babor T F, Steinberg K, Anton R, Del Boca F, Talk is cheap: measuring drinking outcomes in clinical trials., 10.15288/jsa.2000.61.55
  4. Barrias J A, Psyquiatr Clin, 18, 149 (1997)
  5. Besson Jacques, Aeby Francois, Kasas Antoine, Lehert Philippe, Potgieter Adriaan, Combined Efficacy of Acamprosate and Disulfiram in the Treatment of Alcoholism: A Controlled Study, 10.1111/j.1530-0277.1998.tb04295.x
  6. Borg S, Randomised controlled trial of acamprosate versus placebo in Swedish alcoholics (2003)
  7. Chermack Stephen T., Singer Kathleen, Beresford Thomas P., Screening for Alcoholism Among Medical Inpatients: How Important Is Corroboration of Patient Self-Report?, 10.1111/j.1530-0277.1998.tb03925.x
  8. Chick J., A MULTICENTRE, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF NALTREXONE IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ABUSE, 10.1093/alcalc/35.6.587
  9. Chick J., UNITED KINGDOM MULTICENTRE ACAMPROSATE STUDY (UKMAS): A 6-MONTH PROSPECTIVE STUDY OF ACAMPROSATE VERSUS PLACEBO IN PREVENTING RELAPSE AFTER WITHDRAWAL FROM ALCOHOL, 10.1093/alcalc/35.2.176
  10. Dahchour A., De Witte P., Ethanol and amino acids in the central nervous system: assessment of the pharmacological actions of acamprosate, 10.1016/s0301-0082(99)00031-3
  11. Davidson Dena, Palfai Tibor, Bird Chris, Swift Robert, Effects of Naltrexone on Alcohol Self-Administration in Heavy Drinkers, 10.1111/j.1530-0277.1999.tb04099.x
  12. DerSimonian Rebecca, Laird Nan, Meta-analysis in clinical trials, 10.1016/0197-2456(86)90046-2
  13. Elderton William Palin, Johnson Norman Lloyd, Systems of Frequency Curves, ISBN:9780511569654, 10.1017/cbo9780511569654
  14. Fine E W, Steer R A, Scoles P E, Relationship between blood alcohol concentration and self-reported drinking behavior., 10.15288/jsa.1978.39.466
  15. Garbutt James C., West Suzanne L., Carey Timothy S., Lohr Kathleen N., Crews Fulton T., Pharmacological Treatment of Alcohol Dependence : A Review of the Evidence, 10.1001/jama.281.14.1318
  16. Geerlings Peter J., Ansoms Constant, van den Brink Wim, Acamprosate and Prevention of Relapse in Alcoholics, 10.1159/000259166
  17. Gual A., ACAMPROSATE DURING AND AFTER ACUTE ALCOHOL WITHDRAWAL: A DOUBLE-BLIND PLACEBO-CONTROLLED STUDY IN SPAIN, 10.1093/alcalc/36.5.413
  18. Hesselbrock Michie, Babor Thomas F., Hesselbrock Victor, Meyer Roger E., Workman Kathy, “Never Believe an Alcoholic”? On the Validity of Self-Report Measures of Alcohol Dependence and Related Constructs, 10.3109/10826088309027359
  19. Kranzler Henry R., Kirk Jeffrey, Efficacy of Naltrexone and Acamprosate for Alcoholism Treatment: A Meta-Analysis, 10.1111/j.1530-0277.2001.tb02356.x
  20. Koob George F., Mason Barbara J., Witte Philippe, Littleton John, Siggins George R., Potential Neuroprotective Effects of Acamprosate, 10.1111/j.1530-0277.2002.tb02578.x
  21. Ladewig D, Therapeutische Umschau, 50, 182 (1993)
  22. LITTLETON JOHN, Acamprosate in alcohol dependence: how does it work?, 10.1111/j.1360-0443.1995.tb01088.x
  23. Mason Barbara J., Ownby Raymond L., Acamprosate for the Treatment of Alcohol Dependence: A Review of Double-Blind, Placebo-Controlled Trials, 10.1017/s1092852900012827
  24. O'Malley Stephanie S., Naltrexone and Coping Skills Therapy for Alcohol Dependence : A Controlled Study, 10.1001/archpsyc.1992.01820110045007
  25. Paille M, Alcohol Alcohol, 30, 239 (1995)
  26. Pelc I., Le Bon O., Verbanck P., Lehert Ph., Opsomer L., Calcium-Acetylhomotaurinate for Maintaining Abstinence in Weaned Alcoholic Patients: A Placebo-Controlled Double-Blind Multicenter Study, Novel Pharmacological Interventions for Alcoholism (1992) ISBN:9781461277057 p.348-352, 10.1007/978-1-4612-2878-3_44
  27. Pelc I., Verbanck P., Le Bon O., Gavrilovic M., Lion K., Lehert P., Efficacy and safety of acamprosate in the treatment of detoxified alcohol-dependent patients. A 90-day placebo-controlled dose-finding study, 10.1192/bjp.171.1.73
  28. POLDRUGO F., Acamprosate treatment in a long-term community-based alcohol rehabilitation programme, 10.1111/j.1360-0443.1997.tb02873.x
  29. Roussaux J-P, J Pharm Belgique, 51, 65 (1996)
  30. Sass Henning, Relapse Prevention by Acamprosate : Results From a Placebo-Controlled Study on Alcohol Dependence, 10.1001/archpsyc.1996.01830080023006
  31. Sahai Hardeo, Misra Satish, Definitions of Sample Variance: Some Teaching Problems to be Overcome, 10.2307/2348636
  32. Spanagel R, Effects on alcohol intake following alcohol deprivation in the rat. Eur J Pharmacol, 305, 39 (1996)
  33. Naltrexone-induced alterations in human ethanol intoxication, 10.1176/ajp.151.10.1463
  34. Tempesta E., ACAMPROSATE AND RELAPSE PREVENTION IN THE TREATMENT OF ALCOHOL DEPENDENCE: A PLACEBO-CONTROLLED STUDY, 10.1093/alcalc/35.2.202
  35. Effect of naltrexone on alcohol "high" in alcoholics, 10.1176/ajp.152.4.613
  36. Whitworth A.B, Oberbauer H, Fleischhacker W.W, Lesch O.M, Walter H, Nimmerrichter A, Platz T, Fischer F, Potgieter A, Comparison of acamprosate and placebo in long-term treatment of alcohol dependence, 10.1016/s0140-6736(96)91682-7
Référence bibliographique Chick, J. ; Landron, Frédéric ; Lehert, Philippe. Does acamprosate improve reduction of drinking as well as aiding abstinence? . In: Journal of PsychoPharmacology, Vol. 17 (2003)
Permalien http://hdl.handle.net/2078/18682