The ‘4 per mille Soils for Food Security and Climate’ was launched at the COP21 with an aspiration to increase global soil organic matter stocks by 4 per 1000 (or 0.4 %) per year as a compensation for the global emissions of greenhouse gases by anthropogenic sources. This paper surveyed the soil organic carbon (SOC) stock estimates and sequestration potentials from20 regions in the world (New Zealand, Chile, South Africa, Australia, Tanzania,Indonesia, Kenya, Nigeria, India, China Taiwan, South Korea, China Mainland, United States of America, France, Canada, Belgium, England & Wales, Ireland, Scotland, and Russia). We asked whether the 4 per mille initiative is feasible for the region. The outcomes highlight region specific efforts and scopes for soil carbon sequestration. Reported soil C sequestration rates globally show that under best management practices, 4 per mille or even higher sequestration rates can be accomplished. High C sequestration rates (up to 10 per mille) can be achieved for soils with low initial SOC stock (topsoil less than 30 t C ha−1), and at the first twenty years after implementation of best management practices. In addition, areaswhich have reached equilibriumwill not be able to further increase their sequestration.Wefound that most studies on SOC sequestration only consider topsoil (up to 0.3m depth), as it is considered to bemost affected bymanagement techniques. The 4 per mille number was based on a blanket calculation of the whole global soil profile C stock, however the potential to increase SOC is mostly on managed agricultural lands. Ifwe consider 4 per mille in the top 1mof global agricultural soils, SOC sequestration is between 2-3 Gt C year−1, which effectively offset 20–35% of global anthropogenic greenhouse gas emissions. As a strategy for climate change mitigation, soil carbon sequestration buys time over the next ten to twenty yearswhile other effective sequestration and lowcarbon technologies become viable.