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Expression of the ankyrin repeat domain 6 gene (Ankrd6) during mouse brain development.

Onglets principaux

Tissir, Fadel [UCL] Bar, Isabelle [FUNDP] Goffinet, André [UCL] Lambert De Rouvroit, Catherine

The structure and developmental expression pattern of the ankyrin repeat domain 6 (Ankrd6) gene, initially named Diversin, were studied in the mouse. Ankrd6 is transcribed as a 5.8-kb mRNA composed of 15 exons that encodes a 712 amino acid protein with 6 ankyrin repeats. Ankrd6 is expressed prominently in the developing brain from E12 to maturity, suggesting a role during brain development. In embryos, expression is maximal in ventricular zones of neuronal proliferation and intermediate zones of neuronal migration and extends to postmigratory neuronal fields during the postnatal period. In the mature brain, the Ankrd6-related signal is highest in cortical layer II, granule cells of the dentate gyrus, olfactory granules and a subset of Purkinje cells in the vestibulocerebellum. Ankrd6 is related to the Drosophila gene Diego, which interacts with Flamingo in the regulation of planar cell polarity (Feiguin et al., 2001). However, the canvas of Ankrd6 expression does not match closely that of the three mouse Flamingo homologs, Celsr1-3 (Tissir et al., 2002). These data suggest that Ankrd6 may be involved in brain development in interaction with Celsr/Flamingo but also other signaling pathways.

Type de document Article de périodique (Journal article) – Article de recherche
Type d'accès Accès restreint
Année de publication 2002
Information sur le périodique "Developmental dynamics : an official publication of the American Association of Anatomists" - Vol. 224, no. 4, p. 465-9 (2002)
Peer reviewed oui
issn 1058-8388
Statut de la publication Publié
Affiliations UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject Amino Acid Sequence ; Animals ; Ankyrin Repeat - genetics ; Brain - embryology - growth & development - physiology ; Cytoskeletal Proteins - chemistry - genetics - metabolism ; Drosophila Proteins - genetics ; Embryo, Mammalian - anatomy & histology - physiology ; Gene Expression Regulation, Developmental ; Humans ; In Situ Hybridization ; Intracellular Signaling Peptides and Proteins ; Mice ; Molecular Sequence Data ; RNA, Messenger - genetics - metabolism ; Sequence Alignment
Mots-clés Brain development ; In situ hybridization ; Cerebral cortex ; Cerebellum ; Ankyrin repeat ; Diego ; Celsr
Liens
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Référence bibliographique Tissir, Fadel ; Bar, Isabelle ; Goffinet, André ; Lambert De Rouvroit, Catherine. Expression of the ankyrin repeat domain 6 gene (Ankrd6) during mouse brain development.. In: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 224, no. 4, p. 465-9 (2002)
Permalien http://hdl.handle.net/2078.1/12896