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The leader protein of Theiler's virus interferes with nucleocytoplasmic trafficking of cellular proteins.

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Delhaye, Sophie [UCL] Van Pesch, Vincent [UCL] Michiels, Thomas [UCL]

The leader protein of Theiler's virus was previously shown to block the production of alpha/beta interferon by infected cells. Here, we observed that expression of the leader protein in infected cells triggered subcellular redistribution of a nucleus-target green fluorescent protein. It enhanced redistribution of the nuclear polypyrimidine tract-binding protein but had no influence on the localization of the nuclear splicing factor SC-35. The leader protein also interfered with trafficking of the cytoplasmic interferon regulatory factor 3, a factor critical for transcriptional activation of alpha/beta interferon genes.

Type de document Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Type d'accès Accès libre
Année de publication 2004
Information sur le périodique "Journal of Virology" - Vol. 78, no. 8, p. 4357-4362 (2004)
Peer reviewed oui
Editeur American Society for Microbiology ((United States) [S.l.])
issn 0022-538X
e-issn 1098-5514
Statut de la publication Publié
Affiliations UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject Active Transport, Cell Nucleus ; Animals ; BALB 3T3 Cells ; Cell Line ; Cytoplasm - metabolism - virology ; DNA-Binding Proteins - metabolism ; Green Fluorescent Proteins ; Interferon Regulatory Factor-3 ; Luminescent Proteins - metabolism ; Mice ; Mutation ; Nuclear Localization Signals - genetics - physiology ; Nuclear Proteins - metabolism ; Recombinant Fusion Proteins - metabolism ; Theilovirus - genetics - pathogenicity - physiology ; Transcription Factors - metabolism ; Viral Proteins - physiology
Liens
Référence bibliographique Delhaye, Sophie ; Van Pesch, Vincent ; Michiels, Thomas. The leader protein of Theiler's virus interferes with nucleocytoplasmic trafficking of cellular proteins.. In: Journal of Virology, Vol. 78, no. 8, p. 4357-4362 (2004)
Permalien http://hdl.handle.net/2078.1/12841