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Effects of intrathecal ketamine in the neonatal rat: evaluation of apoptosis and long-term functional outcome.

Onglets principaux

Walker, Suellen M Westin, B David Deumens, Ronald [UCL] Grafe, Marjorie Yaksh, Tony L

Because acute pathology and long-term behavioral change occurred in the same dose range as antihyperalgesic effects, the therapeutic ratio of intrathecal ketamine is less than one in the neonatal rat. This measure facilitates comparison of the relative safety of spinally administered analgesic agents.

Type de document Article de périodique (Journal article) – Article de recherche
Type d'accès Accès restreint
Année de publication 2010
Langue Anglais
Information sur le périodique "Anesthesiology" - Vol. 113, no.1, p. 147-59 (2010)
Peer reviewed oui
Editeur Lippincott Williams & Wilkins ((United States) Philadelphia)
issn 0003-3022
e-issn 1528-1175
Statut de la publication Publié
Affiliations UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
MESH Subject Analgesics ; Injections, Spinal ; Ketamine ; Male ; Neuroglia ; Rats ; Rats, Sprague-Dawley ; Sodium Chloride ; Spinal Cord ; Analysis of Variance ; Animals ; Animals, Newborn ; Apoptosis ; Behavior, Animal ; Dose-Response Relationship, Drug ; Female ; Gait
Liens
Référence bibliographique Walker, Suellen M ; Westin, B David ; Deumens, Ronald ; Grafe, Marjorie ; Yaksh, Tony L. Effects of intrathecal ketamine in the neonatal rat: evaluation of apoptosis and long-term functional outcome.. In: Anesthesiology, Vol. 113, no.1, p. 147-59 (2010)
Permalien http://hdl.handle.net/2078.1/125354