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Journal article

Inhibition of the ERK pathway promotes apoptosis induced by 2-chloro-2'-deoxyadenosine in the B-cell leukemia cell line EHEB.

Smal, Caroline[UCL] Lisart, Stéphanie[UCL] Ferrant, Augustin[UCL] Bontemps, Françoise[UCL] Van Den Neste, Eric[UCL] (2006) Nucleosides, nucleotides & nucleic acids — Vol. 25, no. 9-11, p. 1009-12 (2006)

Journal article

Targeting DNA repair with aphidicolin sensitizes primary chronic lymphocytic leukemia cells to purine analogs.

Starczewska, Eliza[UCL] Beyaert, Maxime[UCL] Michaux, Lucienne[UCL] Vekemans, Marie-Christiane[UCL] Saussoy, Pascale[UCL] Bol, Vanesa[UCL] Arana Echarri, Ainhoa[UCL] Smal, Caroline[UCL] Van Den Neste, Eric[UCL] Bontemps, Françoise[UCL] (2016) OncoTarget — Vol. 7, no. 25, p. 38367-38379 (2016)

Journal article

Nucleoside analogs induce proteasomal down-regulation of p21 in chronic lymphocytic leukemia cell lines

Bastin-Coyette, Laurent[UCL] Cardoen, Sabine[UCL] Smal, Caroline[UCL] De Viron, Emeline[UCL] Arts, Angélique[UCL] Amsaïlale, Rachid[UCL] Van Den Neste, Eric[UCL] Bontemps, Françoise[UCL] (2011) Biochemical Pharmacology — Vol. 81, no. 5, p. 586-593 (2011)

Journal article

Phosphorylation of deoxycytidine kinase on Ser-74: impact on kinetic properties and nucleoside analog activation in cancer cells

Amsaïlale, Rachid[UCL] Van Den Neste, Eric[UCL] Arts, Angélique[UCL] Starczewska, Eliza[UCL] Bontemps, Françoise[UCL] Smal, Caroline[UCL] (2012) Biochemical Pharmacology — Vol. 84, no. 1, p. 43-51 (2012)

Journal article

Resistance to 2-chloro-2'-deoxyadenosine of the human B-cell leukemia cell line EHEB.

Cardoen, Sabine Van Den Neste, Eric[UCL] Smal, Caroline[UCL] Rosier, Jean-François Delacauw, Anne Ferrant, Augustin[UCL] Van den Berghe, Georges[UCL] Bontemps, Françoise[UCL] (2001) Clinical cancer research : an official journal of the American Association for Cancer Research — Vol. 7, no. 11, p. 3559-66 (2001)

Journal article

Effects of 2-chloro-2'-deoxyadenosine on the cell cycle in the human leukemia EHEB cell line.

Cardoen, S. Van Den Neste, Eric[UCL] Smal, Caroline[UCL] Rosier, Jean-Claude[UCL] Ferrant, Augustin[UCL] Van den Berghe, Georges[UCL] Bontemps, Françoise[UCL] (2004) Nucleosides, Nucleotides and Nucleic Acids : an international journal for rapid communication — Vol. 23, no. 8-9, p. 1425-1429 (2004)

Journal article

Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage.

Yang, Chunying Lee, Michael Hao, Jianwei Cui, Xiaoli Guo, Xiaojing Smal, Caroline Bontemps, Françoise[UCL] Ma, Shumei Liu, Xiaodong Engler, David Parker, William B Xu, Bo (2012) Nucleic Acids Research — Vol. 40, no.19, p. 9621-32 (2012)

Journal article

Protein phosphatase 2A regulates deoxycytidine kinase activity via Ser-74 dephosphorylation

Amsaïlale, Rachid[UCL] Beyaert, Maxime[UCL] Smal, Caroline[UCL] Janssens, Veerle Van Den Neste, Eric[UCL] Bontemps, Françoise[UCL] (2014) FEBS Letters — Vol. 588, no. 5, p. 727-732 (2014)

Journal article

Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM

Alonso, Roberto López-Guerra, Mónica Upshaw, Ramanda Bantia, Shanta Smal, Caroline[UCL] Bontemps, Françoise[UCL] Manz, Chantal Mehrling, Thomas Villamor, Neus Campo, Elias Montserrat, Emili Colomer, Dolors (2009) Blood — Vol. 114, no. 8, p. 1563-1575 (2009)

Journal article

Activation of deoxycytidine kinase by UV-C-irradiation in chronic lymphocytic leukemia B-lymphocytes.

Van Den Neste, Eric[UCL] Smal, Caroline[UCL] Cardoen, Sabine[UCL] Delacauw, Anne[UCL] Frankard, Joëlle[UCL] Ferrant, Augustin[UCL] Van den Berghe, Georges[UCL] Bontemps, Françoise[UCL] (2003) Biochemical pharmacology — Vol. 65, no. 4, p. 573-80 (2003)

Journal article

Activation of deoxycytidine kinase by protein kinase inhibitors and okadaic acid in leukemic cells

Smal, Caroline[UCL] Cardoen, Sabine[UCL] Bertrand, Luc[UCL] Delacauw, Anne[UCL] Ferrant, Augustin[UCL] Van den Berghe, Georges[UCL] Van Den Neste, Eric[UCL] Bontemps, Françoise[UCL] (2004) Current Vascular Pharmacology — Vol. 68, no. 1, p. 95-103 (2004)

Journal article

Identification of phosphorylation sites on human deoxycytidine kinase after overexpression in eucaryotic cells.

Smal, Caroline[UCL] Vertommen, Didier[UCL] Bertrand, Luc[UCL] Rider, Mark H.[UCL] Van Den Neste, Eric[UCL] Bontemps, Françoise[UCL] (2006) Nucleosides, nucleotides & nucleic acids — Vol. 25, no. 9-11, p. 1141-6 (2006)

Journal article

Identification of in vivo phosphorylation sites on human deoxycytidine kinase. Role of Ser-74 in the control of enzyme activity.

Smal, Caroline[UCL] Vertommen, Didier[UCL] Bertrand, Luc[UCL] Ntamashimikiro, Sandrine[UCL] Rider, Mark H.[UCL] Van Den Neste, Eric[UCL] Bontemps, Françoise[UCL] (2006) The Journal of biological chemistry — Vol. 281, no. 8, p. 4887-93 (2006)

Speech

Impaired up-Regulation of Polo-Like Kinase 2 (PLK2) during Fludarabine- and 2-Chlorodeoxyadenosine (CdA)-Induced Cell Killing in B-Cell Chronic Lymphocytic Leukemia (B-CLL) Lymphocytes: A Potential Marker of Defective Damage Response

de Viron, Emeline[UCL] Knoops, Laurent[UCL] Michaux, Lucienne[UCL] Saussoy, Pascale[UCL] Van Den Neste, Eric[UCL] Connerotte, Thierry[UCL] Smal, Caroline[UCL] Bontemps, Françoise[UCL] (2008) 50th Annual Meeting of the American- Society-of-Hematology — San Francisco (Ca)

Journal article

Impaired up-regulation of polo-like kinase 2 in B-cell chronic lymphocytic leukaemia lymphocytes resistant to fludarabine and 2-chlorodeoxyadenosine : a potential marker of defective damage response

de Viron, Emeline[UCL] Knoops, Laurent[UCL] Connerotte, Thierry[UCL] Smal, Caroline[UCL] Michaux, Lucienne[UCL] Saussoy, Pascale[UCL] Vannuffel, Pascal Beert, Eline Vekemans, Marie-Christiane[UCL] Hermans, Cédric[UCL] Bontemps, Françoise[UCL] Van Den Neste, Eric[UCL] (2009) British Journal of Haematology — Vol. 147, no. 5, p. 641-652 (2009)

Journal article

New evidences for a regulation of deoxycytidine kinase activity by reversible phosphorylation.

Smal, Caroline[UCL] Bertrand, Luc[UCL] Van Den Neste, Eric[UCL] Cardoen, S[UCL] Veiga da Cunha, Maria[UCL] Marie, S.[UCL] Race, V[UCL] Ferrant, Augustin[UCL] Van den Berghe, Georges[UCL] Bontemps, Françoise[UCL] (2004) Nucleosides, nucleotides & nucleic acids — Vol. 23, no. 8-9, p. 1363-5 (2004)

Dissertation

Post-translational regulation of deoxycytidine kinase activity : identification of Serine 74 as a crucial phosphorylation site for deoxycytidine kinase activity in leukemic cells

Smal, Caroline[UCL] (2006)

Journal article

Pharmacological inhibition of the MAPK/ERK pathway increases sensitivity to 2-chloro-2'-deoxyadenosine (CdA) in the B-cell leukemia cell line EHEB.

Smal, Caroline[UCL] Lisart, Stéphanie[UCL] Maerevoet, Marie Ferrant, Augustin[UCL] Bontemps, Françoise[UCL] Van Den Neste, Eric[UCL] (2007) Biochemical Pharmacology — Vol. 73, no. 3, p. 351-358 (2007)

Journal article

Positive regulation of deoxycytidine kinase activity by phosphorylation of Ser-74 in B-cell chronic lymphocytic leukaemia lymphocytes.

Smal, Caroline[UCL] Van Den Neste, Eric[UCL] Maerevoet, Marie[UCL] Poire, Xavier[UCL] Théate, Ivan[UCL] Bontemps, Françoise[UCL] (2007) Cancer Letters — Vol. 253, no. 1, p. 68-73 (2007)

Journal article

Mechanisms of cell death induced by 2-chloroadenosine in leukemic B-cells

Bastin-Coyette, Laurent[UCL] Smal, Caroline[UCL] Cardoen, Sabine[UCL] Saussoy, Pascale[UCL] Van Den Neste, Eric[UCL] Bontemps, Françoise[UCL] (2008) Biochemical Pharmacology — Vol. 75, no. 7, p. 1451-1460 (2008)

Journal article

Influence of phosphorylation of THR-3, SER-11, and SER-15 on deoxycytidine kinase activity and stability.

Smal, Caroline[UCL] Ntamashimikiro, Sandrine[UCL] Arts, Angelique[UCL] Van Den Neste, Eric[UCL] Bontemps, Françoise[UCL] (2010) Nucleosides, Nucleotides and Nucleic Acids : an international journal for rapid communication — Vol. 29, no. 4-6, p. 404-407 (2010)

Journal article

Casein kinase 1 delta activates human recombinant deoxycytidine kinase by Ser-74 phosphorylation, but is not involved in the in vivo regulation of its activity

Smal, Caroline[UCL] Van Den Neste, Eric[UCL] Vertommen, Didier[UCL] Amsaïlale, Rachid[UCL] Arts, Angelique[UCL] Degand, Hervé[UCL] Morsomme, Pierre[UCL] Rider, Mark H.[UCL] Bontemps, Françoise[UCL] (2010) Archives of Biochemistry and Biophysics — Vol. 502, no. 1, p. 44-52 (2010)

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