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Journal article

Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study.

Mebazaa, Alexandre Geven, Christopher Hollinger, Alexa Wittebole, Xavier[UCL] Chousterman, Benjamin Glen Blet, Alice Gayat, Etienne Hartmann, Oliver Scigalla, Paul Struck, Joachim Bergmann, Andreas Antonelli, Massimo Beishuizen, Albertus Constantin, Jean-Michel Damoisel, Charles Deye, Nicolas Di Somma, Salvatore Dugernier, Thierry François, Bruno Gaudry, Stephane Huberlant, Vincent Lascarrou, Jean-Baptiste Marx, Gernot Mercier, Emmanuelle Oueslati, Haikel Pickkers, Peter Sonneville, Romain Legrand, Matthieu Laterre, Pierre-François[UCL] AdrenOSS-1 study investigators (2018) Critical Care — Vol. 22, no.1, p. 354 (2018)

Journal article

Proenkephalin A 119-159 (Penkid) Is an Early Biomarker of Septic Acute Kidney Injury: The Kidney in Sepsis and Septic Shock (Kid-SSS) Study.

Hollinger, Alexa Wittebole, Xavier[UCL] François, Bruno Pickkers, Peter Antonelli, Massimo Gayat, Etienne Chousterman, Benjamin Glen Lascarrou, Jean-Baptiste Dugernier, Thierry Di Somma, Salvatore Struck, Joachim Bergmann, Andreas Beishuizen, Albertus Constatin, Jean-Michel Damoisel, Charles Deye, Nicolas Gaudry, Stéphane Huberlant, Vincent Marx, Gernot Mercier, Emanuelle Oueslati, Haikel Hartmann, Oliver Sonneville, Romain Laterre, Pierre-François[UCL] Mebazaa, Alexandre Legrand, Matthieu (2018) Kidney International Reports — Vol. 3, no.6, p. 1424-1433 (2018)

Journal article

Rationale and Design of an Adaptive Phase 2b/3 Clinical Trial of Selepressin for Adults in Septic Shock. Selepressin Evaluation Programme for Sepsis-induced Shock-Adaptive Clinical Trial.

Lewis, Roger J Angus, Derek C Laterre, Pierre-François[UCL] Kjølbye, Anne Louise van der Meulen, Egbert Blemings, Allan Graves, Todd Russell, James A Carlsen, Jan E Jacobsen, Karsten Yealy, Donald M Opal, Steven M Windeløv, Nis A François, Bruno Perner, Anders Pickkers, Peter Berry, Scott M (2018) Annals of the American Thoracic Society — Vol. 15, no. 2, p. 250-257 (2018)

Journal article

A worldwide multicentre evaluation of the influence of deterioration or improvement of acute kidney injury on clinical outcome in critically ill patients with and without sepsis at ICU admission: results from The Intensive Care Over Nations audit.

Peters, Esther Antonelli, Massimo Wittebole, Xavier[UCL] Nanchal, Rahul François, Bruno Sakr, Yasser Vincent, Jean-Louis Pickkers, Peter (2018) Critical Care — Vol. 22, no.1, p. 188 (2018)

Journal article

Association of Interleukin 7 Immunotherapy With Lymphocyte Counts Among Patients With Severe Coronavirus Disease 2019 (COVID-19).

Laterre, Pierre-François[UCL] François, Bruno Collienne, Christine[UCL] Hantson, Philippe[UCL] Jeannet, Robin Remy, Kenneth E Hotchkiss, Richard S (2020) JAMA network open — Vol. 3, no.7, p. e2016485 [1-5] (2020)

Journal article

New Agents in Development for Sepsis: Any Reason for Hope?

Vignon, Philippe Laterre, Pierre-François[UCL] Daix, Thomas François, Bruno (2020) Drugs — Vol. 80, no.17, p. 1751-1761 (2020)

Journal article

Prognostic performance of endothelial biomarkers to early predict clinical deterioration of patients with suspected bacterial infection and sepsis admitted to the emergency department.

Lafon, Thomas Cazalis, Marie-Angélique Vallejo, Christine Tazarourte, Karim Blein, Sophie Pachot, Alexandre Laterre, Pierre-François[UCL] Laribi, Said François, Bruno TRIAGE study group Verschuren, Franck[UCL] Fabry, Manon[UCL] (2020) Annals of intensive care — Vol. 10, no.1, p. 113 [1-12] (2020)

Journal article

Nangibotide in patients with septic shock: a Phase 2a randomized controlled clinical trial.

François, Bruno Wittebole, Xavier[UCL] Ferrer, Ricard Mira, Jean-Paul Dugernier, Thierry Gibot, Sébastien Derive, Marc Olivier, Aurélie Cuvier, Valérie Witte, Stephan Pickkers, Peter Vandenhende, François Garaud, Jean-Jacques Sánchez, Miguel Salcedo-Magguilli, Margarita Laterre, Pierre-François[UCL] (2020) Intensive care medicine — Vol. 46, no.7, p. 1425-1437 (2020)

Journal article

The challenge of ventilator-associated pneumonia diagnosis in COVID-19 patients.

François, Bruno Laterre, Pierre-François[UCL] Luyt, Charles-Edouard Chastre, Jean (2020) Critical care — Vol. 24, no.1, p. 289 (2020)

Journal article

A phase Ib/IIa, randomised, double-blind, multicentre trial to assess the safety and efficacy of expanded Cx611 allogeneic adipose-derived stem cells (eASCs) for the treatment of patients with community-acquired bacterial pneumonia admitted to the intensive care unit.

Laterre, Pierre-François[UCL] Sánchez-García, Miguel van der Poll, Tom de la Rosa, Olga Cadogan, Kathy-Ann Lombardo, Eleuterio François, Bruno (2020) BMC pulmonary medicine — Vol. 20, no.1, p. 309 [1-11] (2020)

Journal article

Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial.

Laterre, Pierre-François[UCL] Berry, Scott M Blemings, Allan Carlsen, Jan E François, Bruno Graves, Todd Jacobsen, Karsten Lewis, Roger J Opal, Steven M Perner, Anders Pickkers, Peter Russell, James A Windeløv, Nis A Yealy, Donald M Asfar, Pierre Bestle, Morten H Muller, Grégoire Bruel, Cédric Brulé, Noëlle Decruyenaere, Johan Dive, Alain-Michel[UCL] Dugernier, Thierry Krell, Kenneth Lefrant, Jean-Yves Megarbane, Bruno Mercier, Emmanuelle Mira, Jean-Paul Quenot, Jean-Pierre Rasmussen, Bodil Steen Thorsen-Meyer, Hans-Christian Vander Laenen, Margot Vang, Marianne Lauridsen Vignon, Philippe Vinatier, Isabelle Wichmann, Sine Wittebole, Xavier[UCL] Kjølbye, Anne Louise Angus, Derek C SEPSIS-ACT Investigators (2019) JAMA — Vol. 322, no. 15, p. 1476-1485 (2019)

Journal article

Early Corticosteroid Therapy May Increase Ventilator-Associated Lower Respiratory Tract Infection in Critically Ill Patients with COVID-19: A Multicenter Retrospective Cohort Study.

Mesland, Jean-Baptiste[UCL] Carlier, Eric François, Bruno Serck, Nicolas Gérard, Ludovic[UCL] Briat, Charlotte Piagnerelli, Michael Laterre, Pierre-François[UCL] On Behalf Of The Covcorvap Collaboration Group (2022) Microorganisms — Vol. 10, no.5, p. 984 [1-13] (2022)

Journal article

Temporal changes in the epidemiology, management, and outcome from acute respiratory distress syndrome in European intensive care units: a comparison of two large cohorts.

Sakr, Yasser François, Bruno Solé-Violan, Jordi Kotfis, Katarzyna Jaschinski, Ulrich Estella, Angel Leone, Marc Jakob, Stephan M Wittebole, Xavier[UCL] Fontes, Luis E de Melo Gurgel, Miguel Midega, Thais Vincent, Jean-Louis Ranieri, V Marco SOAP and ICON Investigators Installé, Etienne[UCL] Dive, Alain-Michel[UCL] (2021) Critical care — Vol. 25, no.1, p. 87 [1-12] (2021)

Journal article

The Prognostic Value of Brain Dysfunction in Critically Ill Patients with and without Sepsis: A Analysis of the ICON Audit.

Crippa, Ilaria A Taccone, Fabio S Wittebole, Xavier[UCL] Martin-Loeches, Ignacio Schroeder, Mary E François, Bruno Kotfis, Katarzyna Ñamendys-Silva, Silvio A Forceville, Xavier Solé-Violán, Jordi Fontes, Luis E Vincent, Jean-Louis On Behalf Of The Icon Investigators, (2021) Brain sciences — Vol. 11, no.5, p. 530 [1-10] (2021)

Journal article

Monitoring circulating dipeptidyl peptidase 3 (DPP3) predicts improvement of organ failure and survival in sepsis: a prospective observational multinational study.

Blet, Alice Deniau, Benjamin Santos, Karine van Lier, Dirk P T Azibani, Feriel Wittebole, Xavier[UCL] Chousterman, Benjamin G Gayat, Etienne Hartmann, Oliver Struck, Joachim Bergmann, Andreas Antonelli, Massimo Beishuizen, Albertus Constantin, Jean-Michel Damoisel, Charles Deye, Nicolas Di Somma, Salvatore Dugernier, Thierry François, Bruno Gaudry, Stephane Huberlant, Vincent Lascarrou, Jean-Baptiste Marx, Gernot Mercier, Emmanuelle Oueslati, Haikel Pickkers, Peter Sonneville, Romain Legrand, Matthieu Laterre, Pierre-François[UCL] Mebazaa, Alexandre AdrenOSS-1 Study Investigators (2021) Critical care — Vol. 25, no.1, p. 61 [1-10] (2021)

Journal article

Efficacy and safety of human soluble thrombomodulin (ART-123) for treatment of patients in France with sepsis-associated coagulopathy: post hoc analysis of SCARLET.

François, Bruno Fiancette, Maud Helms, Julie Mercier, Emmanuelle Lascarrou, Jean-Baptiste Kayanoki, Toshihiko Tanaka, Kosuke Fineberg, David Vincent, Jean-Louis Wittebole, Xavier[UCL] (2021) Annals of intensive care — Vol. 11, no.1, p. 53 [1-8] (2021)

Journal article

Strengths and limitations of industry vs. academic randomized controlled trials.

Laterre, Pierre-François[UCL] François, Bruno (2015) Clinical Microbiology and Infection — Vol. 21, no. 10, p. 906-909 (2015)

Journal article

Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit.

Vincent, Jean-Louis Marshall, John C Namendys-Silva, Silvio A François, Bruno Martin-Loeches, Ignacio Lipman, Jeffrey Reinhart, Konrad Antonelli, Massimo Pickkers, Peter Njimi, Hassane Jimenez, Edgar Sakr, Yasser ICON investigators Wittebole, Xavier[UCL] Dive, Alain-Michel[UCL] (2014) The Lancet Respiratory Medicine — Vol. 2, no.5, p. 380-386 (2014)

Journal article

Safety and tolerability of non-neutralizing adrenomedullin antibody adrecizumab (HAM8101) in septic shock patients: the AdrenOSS-2 phase 2a biomarker-guided trial.

Laterre, Pierre-François[UCL] Pickkers, Peter Marx, Gernot Wittebole, Xavier[UCL] Meziani, Ferhat Dugernier, Thierry Huberlant, Vincent Schuerholz, Tobias François, Bruno Lascarrou, Jean-Baptiste Beishuizen, Albertus Oueslati, Haikel Contou, Damien Hoiting, Oscar Lacherade, Jean-Claude Chousterman, Benjamin Pottecher, Julien Bauer, Michael Godet, Thomas Karakas, Mahir Helms, Julie Bergmann, Andreas Zimmermann, Jens Richter, Kathleen Hartmann, Oliver Pars, Melanie Mebazaa, Alexandre AdrenOSS-2 study participants Castanares Zapatero, Diego[UCL] Collienne, Christine[UCL] Gérard, Ludovic[UCL] Hantson, Philippe[UCL] Montiel, Virginie[UCL] Berghe, Caroline[UCL] Dujardin, Marie-France[UCL] Gielens, Leslie[UCL] Renard, Suzanne[UCL] (2021) Intensive care medicine — Vol. 47, no.11, p. 1284-1294 (2021)

Journal article

Association between timing of intubation and outcome in critically ill patients: A secondary analysis of the ICON audit.

Bauer, Philippe R Gajic, Ognjen Nanchal, Rahul Kashyap, Rahul Martin-Loeches, Ignacio Sakr, Yasser Jakob, Stephan M François, Bruno Wittebole, Xavier[UCL] Wunderink, Richard G Vincent, Jean-Louis ICON Investigators Dive, Alain-Michel[UCL] (2017) Journal of Critical Care — Vol. 42, p. 1-5 (2017)

Journal article

Perspective on optimizing clinical trials in critical care: how to puzzle out recurrent failures.

François, Bruno Clavel, Marc Vignon, Philippe Laterre, Pierre-François[UCL] (2016) Journal of intensive care — Vol. 4, no. 1, p. 67 [1-11] (2016)

Journal article

Pseudomonas aeruginosa serotypes in nosocomial pneumonia: prevalence and clinical outcomes

Lu, Qin Eggimann, Philippe Luyt, Charles-Edouard Wolff, Michel Tamm, Michael François, Bruno Mercier, Emmanuelle Garbino, Jorge Laterre, Pierre-François[UCL] Koch, Holger Gafner, Verena Rudolf, Michael P Mus, Erkan Perez, Antonio Lazar, Hedvika Chastre, Jean Rouby, Jean-Jacques (2014) Critical Care — Vol. 18, no.1, p. R17 [1-9] (2014)

Journal article

The SAATELLITE and EVADE Clinical Studies Within the COMBACTE Consortium: A Public-Private Collaborative Effort in Designing and Performing Clinical Trials for Novel Antibacterial Drugs to Prevent Nosocomial Pneumonia.

François, Bruno Chastre, Jean Eggiman, Philippe Laterre, Pierre-François[UCL] Torres, Antoni Sanchez, Miguel Esser, Mark T Bishop, Brian Bonten, Marc Goosens, Herman Jafri, Hasan S (2016) Clinical Infectious Diseases — Vol. 63, no. suppl 2, p. S46-S51 (2016)

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