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1. • Journal article

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   Investigation of mechanism-based thrombin inhibitors: Implications of a highly conserved water molecule for the binding of coumarins within the S pocket.

   Frédérick, Raphaël[UCL] Charlier, Caroline[FUNDP] Robert, S.[FUNDP] Wouters, Johan[FUNDP] Masereel, Bernard[FUNDP] Pochet, Lionel[FUNDP] (2006) Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology — Vol. 16, no. 7, p. 2017-2021 (2006)
2. • Journal article

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   Mechanism-based thrombin inhibitors: design, synthesis, and molecular docking of a new selective 2-oxo-2H-1-benzopyran derivative.

   Frédérick, Raphaël[UCL] Robert, S.[FUNDP] Charlier, Caroline[FUNDP] Wouters, Johan[FUNDP] Masereel, Bernard[FUNDP] Pochet, Lionel[FUNDP] (2007) Journal of medicinal chemistry — Vol. 50, no. 15, p. 3645-3650 (2007)
3. • Journal article

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   Unravelling the Allosteric Targeting of PHGDH at the ACT-Binding Domain with a Photoactivatable Diazirine Probe and Mass Spectrometry Experiments

   Spillier, Quentin[UCL] Ravez, Séverine Dochain Simon[UCL] Vertommen, Didier[UCL] Thabault, Léopold[UCL] Feron, Olivier[UCL] Frédérick, Raphaël[UCL] (2021) Molecules — Vol. 26, no. 2, p. 477 (2021)
4. • Journal article

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   3,6-disubstituted coumarins as mechanism-based inhibitors of thrombin and factor Xa

   Frédérick, Raphaël[UCL] Robert, S.[FUNDP] Charlier, Caroline[FUNDP] de Ruyck, Jérôme Wouters, Johan[FUNDP] Pirotte, Bernard Masereel, Bernard[FUNDP] Pochet, Lionel[FUNDP] (2005) Journal of Medicinal Chemistry — Vol. 48, no. 24, p. 7592-7603 (2005)
5. • Journal article

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   Discovery of small molecules interacting at lactate dehydrogenases tetrameric interface using a biophysical screening cascade.

   Thabault, Léopold[UCL] Brustenga, Chiara[UCL] Savoyen, Perrine[UCL] Van Gysel, Mégane Wouters, Johan Sonveaux, Pierre[UCL] Frédérick, Raphaël[UCL] Liberelle, Maxime[UCL] (2022) European Journal of Medicinal Chemistry — Vol. 230, p. 114102 (2022)
6. • Journal article

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   Interrogating the lactate dehydrogenase tetramerization site using (stapled) peptides.

   Thabault, Léopold[UCL] Brisson, Lucie[UCL] Brustenga, Chiara[UCL] Martinez Gache, Santiago A Prévost, Julien[UCL] Kozlova, Arina[UCL] Spillier, Quentin[UCL] Liberelle, Maxime[UCL] Benyahia, Zohra[UCL] Messens, Joris Copetti, Tamara[UCL] Sonveaux, Pierre[UCL] Frédérick, Raphaël[UCL] (2020) Journal of medicinal chemistry — Vol. 63, no.9, p. 4628-4643 (2020)
7. • Speech

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   Anomalous reactivity of benzopinacolone towards 4-phenylthiosemicarbazide, a nucleophile endowed with alpha-effect.

   Kassehin, Comlan Urbain[UCL] Adjibode, Steeve A Bautista, Oscar[UCL] Gbaguidi, Fernand Quetin-Leclercq, Joëlle[UCL] McCurdy, Christopher R Frédérick, Raphaël[UCL] Poupaert, Jacques[UCL] (2018) 2èmes journées médico-pharmaceutiques de la Faculté des Sciences de la Santé — (Benin) Cotonou
8. • Journal article

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   Needle-free iontophoresis-driven β-adrenergic sweat rate test.

   Reynaerts, Audrey Vermeulen, François Mottais, Angélique Gohy, Sophie[UCL] Lebecque, Raphaël[UCL] Frédérick, Raphaël[UCL] Vanbever, Rita[UCL] Leal, Teresinha[UCL] (2022) Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society — Vol. 21, no.3, p. 407-415 (2022)
9. • Patent

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   Polypeptide inhibitors of lactate dehydrogenase activity for use in cancer therapy

   Sonveaux, Pierre[UCL] Thabault, Léopold[UCL] Liberelle, Maxime[UCL] Frédérick, Raphaël[UCL] (2021)
10. • Speech

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    Identification and development of LDH inhibitors to treat cancer

    Sonveaux, Pierre[UCL] Frédérick, Raphaël[UCL] (2021) Seminar Series of the European Institute of Chemistry and Biology (IECB) —
11. • Journal article

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    Olaparib is a mitochondrial Complex I inhibitor that kills temozolomide-resistant human glioblastoma cells

    Zampieri, Luca[UCL] Sboarina, Martina[UCL] Cacace, Andrea[UCL] Grasso, Debora[UCL] Thabault, Léopold[UCL] Hamelin, Loïc[UCL] Vazeille, Thibaut[UCL] Dumon, Elodie Rossignol, Rodrigue Frédérick, Raphaël[UCL] Sonveaux, Etienne[UCL] Lefranc, Florence Sonveaux, Pierre[UCL] (2021) International Journal of Molecular Sciences — Vol. 22, no.11938, p. 17 (2021)
12. • Journal article

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    Phosphoglycerate dehydrogenase (PHGDH) inhibitors: a comprehensive review 2015-2020

    Quentin Spillier Frédérick, Raphaël[UCL] (2021) Expert Opinion on Therapeutic Patents — Vol. 31, no. 7, p. 597-608 (2021)
13. • Journal article

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    The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate

    Kentache, Takfarinas[UCL] Thabault, Léopold[UCL] DEUMER, Gladys[UCL] Haufroid, Vincent[UCL] Frédérick, Raphaël[UCL] linster, Carole Peracchi, Alessio[UCL] Veiga da Cunha, Maria[UCL] Bommer, Guido[UCL] Van Schaftingen, Emile[UCL] (2021) Journal of Biological Chemistry — Vol. 296, p. 100699 (2021)
14. • Journal article

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    Targeting protein self-association in drug design.

    Thabault, Léopold[UCL] Liberelle, Maxime[UCL] Frédérick, Raphaël[UCL] (2021) Drug Discovery Today — Vol. 26, no. 5, p. 1148-1163 (2021)
15. • Journal article

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    Discovery of a novel lactate dehydrogenase tetramerization domain using epitope mapping and peptides

    Thabault, Léopold[UCL] Liberelle, Maxime[UCL] Koruza, Katarina Yildiz, Esra[UCL] Joudiou, Nicolas[UCL] Messens, Joris Brisson, Lucie Wouters, Johan Sonveaux, Pierre[UCL] Frédérick, Raphaël[UCL] (2021) Journal of Biological Chemistry — Vol. 296, p. 100422 (2021)
16. • Speech

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    Evaluation of antitrypanosomal activity and selectivity of natural and semi-synthetic triterpenic derivatives

    Beaufay, Claire[UCL] Bero, Joanne[UCL] Bonneau, Natacha[UCL] Girardi, Cynthia[UCL] Sanchez, Marianela Leverrier, Aurélie Frédérick, Raphaël[UCL] Palermo, Jorge Quetin-Leclercq, Joëlle[UCL] (2018) BSP Spring Meeting 2018 — (Wales) Aberyswyth
17. • Journal article

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    1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio

    Ameryckx, Alice[UCL] Thabault, Léopold[UCL] Pochet, Lionel Leimanis, Serge Poupaert, Jacques[UCL] Wouters, Johan Joris, Bernard Van Bambeke, Françoise[UCL] Frédérick, Raphaël[UCL] (2018) European Journal of Medicinal Chemistry — Vol. 159, p. 324-338 (2018)
18. • Journal article

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    Investigation of chalcogen bioisosteric replacement in a series of heterocyclic inhibitors of tryptophan 2,3-dioxygenase

    Kozlova, Arina Thabault, Léopold Dauguet, Nicolas Deskeuvre, Marine Stroobant, Vincent Pilotte, Luc Liberelle, Maxime Van den Eynde, Benoît Frédérick, Raphaël[UCL] (2022) European Journal of Medicinal Chemistry — Vol. 227, no.-, p. 113892 (2022)
19. • Journal article

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    Repositioning of FDA-Approved antifungal agents to interrogate Acyl-CoA synthetase long chain family member 4 (ACSL4) in ferroptosis

    Marteau, Romain[UCL] Ravez, Séverine Mazhari Dorooee, Darius Bouchaoui, Hind Porte, Karine[UCL] Devedjian, Jean-Christophe Melnyk, Patricia Devos, David Frédérick, Raphaël[UCL] El Bakali, Jamal (2022) Biochemical Pharmacology — Vol. 204, no.-, p. 115239 (2022)
20. • Journal article

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    Structural study of bioisosteric derivatives of 5-(1<i>H</i>-indol-3-yl)-benzotriazole and their ability to form chalcogen bonds

    Mirgaux, Manon Scaillet, Tanguy Kozlova, Arina[UCL] Tumanov, Nikolay Frédérick, Raphaël[UCL] Bodart, Laurie Wouters, Johan (2022) Acta Crystallographica Section E Crystallographic Communications — Vol. 78, no. 4, p. 418-424 (2022)
21. • Journal article

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    Anomalous reactivity of benzopinacolone towards 4-phenylthiosemicarbazide, a nucleophile endowed with alpha-effect

    Kassehin, Comlan Urbain[UCL] Adjibode, Steeve A Bautista, Oscar[UCL] Gbaguidi, Fernand A Quetin-Leclercq, Joëlle[UCL] McCurdy, Christopher R Frédérick, Raphaël[UCL] Poupaert, Jacques[UCL] (2019) Journal of Medicinal and Chemical Sciences — Vol. 2, no.1, p. 17-20 (2019)
22. • Journal article

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    Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation

    Spillier, Quentin[UCL] Vertommen, Didier[UCL] Séverine Ravez Marteau, Romain[UCL] THÉMANS, Quentin Corbet, Cyril[UCL] Feron, Olivier[UCL] Wouters, Johan Frédérick, Raphaël[UCL] (2019) Scientific Reports — Vol. 9, no. 1, p. 4737 (2019)
23. • Journal article

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    Impact of PEGylation on an antibody-loaded nanoparticle-based drug delivery system for the treatment of inflammatory bowel disease.

    Shrestha, Neha Xu, Yining[UCL] Prévost, Julien R C McCartney, Fiona Brayden, David Frédérick, Raphaël[UCL] Beloqui Garcia, Ana[UCL] Préat, Véronique[UCL] (2022) Acta biomaterialia — Vol. 140, p. 561-572 (2022)
24. • Journal article

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    The putative Escherichia coli dehydrogenase YjhC metabolises two dehydrated forms of N-acetylneuraminate produced by some sialidases

    Kentache, Takfarinas[UCL] Thabault, Léopold[UCL] Peracchi, Alessio Frédérick, Raphaël[UCL] Bommer, Guido[UCL] Van Schaftingen, Emile[UCL] (2020) Bioscience Reports — Vol. 40, no.6, p. 1-15 (2020)
25. • Journal article

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    Targeting cancer cells in acidosis with conjugates between the carnitine palmitoyltransferase 1 inhibitor etomoxir and pH (low) insertion peptides

    Deskeuvre, Marine Lan, Junjie Dierge, Emeline Messens, Joris Riant, Olivier[UCL] Corbet, Cyril[UCL] Feron, Olivier[UCL] Frédérick, Raphaël[UCL] (2022) International Journal of Pharmaceutics — Vol. 624, no.1, p. 122041 (2022)

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