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Journal article

The Stat3-activating Tyk2 V678F mutant does not up-regulate signaling through the type I interferon receptor but confers ligand hypersensitivity to a homodimeric receptor

Gakovic, Milica Ragimbeau, Josiane Francois, Veronique Constantinescu, Stefan N.[UCL] Pellegrini, Sandra (2008) Journal of Biological Chemistry — Vol. 283, no. 27, p. 18522-18529 (2008)

Journal article

Aberrant signal transduction pathways in myeloproliferative neoplasms.

Kota, J Caceres, Nancy[UCL] Constantinescu, Stefan N.[UCL] (2008) Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K — Vol. 22, no. 10, p. 1828-40 (2008)

Journal article

Substitution of pseudokinase domain residue Val-617 by large non-polar amino acids causes activation of JAK2

Dusa, Alexandra[UCL] Staerk, Judith[UCL] Elliott, Joanne Pecquet, Christian[UCL] Poirel, Hélène[UCL] Johnston, James A. Constantinescu, Stefan N.[UCL] (2008) Journal of Biological Chemistry — Vol. 283, no. 19, p. 12941-8 (2008)

Journal article

Erratum : amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs

Kienlen-Campard, Pascal[UCL] Tasiaux, Bernadette[UCL] Van Hees, Joanne[UCL] Li, Mingli[UCL] Huysseune, Sandra[UCL] Sato, Takeshi Fei, Jeffrey Z Aimoto, Saburo Smith, Steven O Constantinescu, Stefan N.[UCL] Octave, Jean-Noël[UCL] (2008) Journal of Biological Chemistry — Vol. 283, no. 12, p. 7733-7744 (2008)

Journal article

Introduction to 'A special spotlight review series on BCR-ABL-negative myeloproliferative neoplasms'

Tefferi, A. Constantinescu, Stefan N.[UCL] (2008) Leukemia — Vol. 22, p. P1-P1 (2008)

Journal article

Mining for JAK-STAT mutations in cancer.

Constantinescu, Stefan N.[UCL] Girardot, Michaël[UCL] Pecquet, Christian[UCL] (2008) Trends in biochemical sciences — Vol. 33, no. 3, p. 122-31 (2008)

Speech

Functional Determination of the Interaction Interface Between the Kinase and Pseudokinase Domains of JAK2 V617F

Dusa, Alexandra[UCL] Constantinescu, Stefan N.[UCL] (2008) 50th Annual Meeting of the American- Society-of-Hematology — San Francisco(Ca)

Journal article

Activating mutations in human acute megakaryoblastic leukemia

Malinge, Sebastien Michaux, Lucienne[UCL] Ragu, Christine Della-Valle, Veronique Pisani, Didier Constantinescu, Stefan N.[UCL] Perez, Christelle Villeval, Jean-Luc Reinhardt, Dirk Landman-Parker, Judith Dastugue, Nicole Baruchel, Andre Vainchenker, William Bourquin, Jean-Pierre Penard-Lacronique, Virginie Bernard, Olivier A. (2008) Blood — Vol. 112, no. 10, p. 4220-6 (2008)

Journal article

JAKs in pathology: Role of Janus kinases in hematopoietic malignancies and immunodeficiencies

Vainchenker, William Dusa, Alexandra[UCL] Constantinescu, Stefan N.[UCL] (2008) Seminars in Cell and Developmental Biology — Vol. 19, no. 4, p. 385-93 (2008)

Journal article

Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif

Kumar, K. G. Suresh Varghese, Bentley Banerjee, Anamika Baker, Darren P. Constantinescu, Stefan N.[UCL] Pellegrini, Sandra Fuchs, Serge Y. (2008) Journal of Biological Chemistry — Vol. 283, no. 27, p. 18566-18572 (2008)

Journal article

Jak2 V617F : Histoire et perspectives d'une nouvelle mutation

Constantinescu, Stefan N.[UCL] (2008) Louvain médical — Vol. 127, no.7, p. 243-246 (2008)

Journal article

Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs

Kienlen-Campard, Pascal[UCL] Tasiaux, Bernadette[UCL] Van Hees, Joanne[UCL] Li, Mingli[UCL] Huysseune, Sandra[UCL] Sato, Takeshi Fei, Jeffrey Z Aimoto, Saburo Courtoy, Pierre J.[UCL] Smith, Steven O. Constantinescu, Stefan N.[UCL] Octave, Jean-Noël[UCL] (2008) Journal of Biological Chemistry — Vol. 283, no. 12, p. 7733-7744 (2008)

Journal article

The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes.

Wernig, Gerlinde Gonneville, Jeffrey R Crowley, Brian J Rodrigues, Margret S Reddy, Mamatha M Hudon, Heidi E Walz, Christoph Reiter, Andreas Podar, Klaus Royer, Yohan Constantinescu, Stefan N.[UCL] Tomasson, Michael H Griffin, James D Gilliland, D Gary Sattler, Martin (2008) Blood — Vol. 111, no.7, p. 3751-3759 (2008)

Journal article

The ubiquitin-mediated degradation of Jak1 modulates osteoclastogenesis by limiting interferon-beta-induced inhibitory signaling.

Lee, Youngkyun Hyung, Seok-Won Jung, Hee Jung Kim, Hyung-Joon Staerk, Judith Constantinescu, Stefan N.[UCL] Chang, Eun-Ju Lee, Zang Hee Lee, Sang-Won Kim, Hong-Hee (2008) Blood — Vol. 111, no.2, p. 885-893 (2008)

Journal article

Using JAK2 inhibitors in myeloproliferative neoplasms

Knoops, Laurent[UCL] Diaconu, Carmen C. Constantinescu, Stefan N.[UCL] (2008) Myeloproliferative Disorders in Practice — Vol. 2, no.1, p. 3-6 (2008)

Journal article

The JAK2V617F mutation can occur in a hematopoietic stem cell that exhibits no proliferative advantage: a case of human allogeneic transplantation.

Van Pelt, Kristien Nollet, Friedel Selleslag, Dominik Knoops, Laurent[UCL] Constantinescu, Stefan N.[UCL] Criel, Arnold Billiet, Johan (2008) Blood — Vol. 112, no.3, p. 921-922 (2008)

Speech

ALL-Associated JAK1 Mutants Activate the JAK/STAT Pathway Via IL-9R alpha Homodimers.

Hornakova, Tekla[UCL] Knoops, Laurent[UCL] Staerk, Judith Royer, Yohan Flex, Elisabetta Tartaglia, Marco Constantinescu, Stefan N.[UCL] Renauld, Jean-Christophe[UCL] (2008) 50th Annual Meeting of the American- Society-of-Hematology — San Francisco (Ca)

Journal article

Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia

Flex, Elisabetta Petrangeli, Valentina Stella, Lorenzo Chiaretti, Sabina Hornakova, Tekla[UCL] Knoops, Laurent[UCL] Ariola, Cristina Fodale, Valentina Clappier, Emmanuelle Sanchez, Massimo Tavolaro, Simona Messina, Monica Cazzaniga, Giovanni Camera, Andrea Pizzolo, Giovanni Tornesello, Assunta Vignetti, Marco Battistini, Angela Cavé, Hélène Gelb, Bruce, D Renauld, Jean-Christophe[UCL] Biondi, Andrea Constantinescu, Stefan N.[UCL] Foa, Robin Tartaglia, Marco (2008) The Journal of Experimental Medicine — Vol. 205, no. 4, p. 751-8 (2008)

Journal article

Ligand-independent Homomeric and Heteromeric Complexes between Interleukin-2 or-9 Receptor Subunits and the gamma Chain

Malka, Yaniv Knoops, Laurent[UCL] Hornakova, Tekla[UCL] Royer, Yohan[UCL] Renauld, Jean-Christophe[UCL] Constantinescu, Stefan N.[UCL] Henis, Yoav I. (2008) Journal of Biological Chemistry — Vol. 283, no. 48, p. 33569-77 (2008)

Journal article

JAK kinases overexpression promotes in vitro cell transformation

Knoops, Laurent[UCL] Hornakova, Tekla[UCL] Royer, Yohan[UCL] Constantinescu, Stefan N.[UCL] Renauld, Jean-Christophe[UCL] (2008) Oncogene : including Oncogene Reviews — Vol. 27, no. 11, p. 1511-9 (2008)

Journal article

Clinical implications of JAK2 mutations in myeloproliferative disorders.

Knoops, Laurent[UCL] Hermans, Cédric[UCL] Ferrant, Augustin[UCL] Constantinescu, Stefan N.[UCL] (2008) Acta clinica Belgica — Vol. 63, no. 2, p. 93-8 (2008)

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